2025 College Football Odds Week 12: Lines, Spreads, Betting Trends on Biggest Games

Patrick Everson Sports Betting Expert

6 minute read

The College Football Odds Week 12 market features a couple of huge SEC matchups with major College Football Playoff ramifications.

Oklahoma vs. Alabama arguably leads the way in college football Week 12 odds. Not far behind, though, is Texas vs. Georgia. And perhaps we'll find out the next star of Who Wants To Win The ACC?

Here’s everything you need to know about college football odds Week 12: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 12 college football odds and action.

Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Kevin Jairaj/Imagn Images)

2025 College Football Odds for Week 12

Notre Dame vs. Pittsburgh Odds

• Opening point spread: Notre Dame -11
• Opening moneyline: Notre Dame TBA/Pittsburgh TBA
• Opening total: Over/Under 58.5 points scored
• Time: Noon ET Saturday (TV TBD)

EARLY WEEK UPDATE: Notre Dame opens and remains 10.5-point road chalk in Borgata Sports' college football odds Week 12 market, as of 6 p.m. ET Monday

"No change in the spread, but we have seen some early recreational money on Notre Dame, laying the 10.5," Borgata sportsbook director Tom Gable said. "The Irish were able to cover the big number Saturday against Navy, but this will certainly be a step up on the road vs. a ranked Pitt team.

"And Notre Dame knows it needs to win, to keep a potential at-large spot in the CFP and possibly gain some style points in the process."

Borgata's total has already moved off the 56.5 opener.

"We took respected money on the Under and have since gone to 55.5," Gable said.

OPENING ODDS UPDATE: Notre Dame (7-2 SU/4-4-1 ATS) is on cruise control to a College Football Playoff bid, currently sitting No. 10 but likely this week to go to at least No. 9. In Week 11, the Fighting Irish hammered Navy 49-10 laying a massive 39.5 points.

Notre Dame is on a seven-game win streak (4-2-1 ATS). In Week 12, the Irish have a chance to further muddy the ACC's championship and CFP pictures.

Pittsburgh (7-2 SU and ATS) is on a 5-0 SU and ATS tear, staying in contention in the ACC. The Panthers had a bye in Week 11 after topping Stanford 35-20 as 13.5-point road favorites.

Circa Sports, whose opening odds often generate immediate sharp action, pegged Notre Dame as 11-point road chalk in college football Week 12 odds. Within minutes Sunday, the line went to -10, then settled at -10.5. The total also quickly adjusted, from 58.5 to 56.5.

Check out VegasInsider's College Football Week 12 Best Bets!

Oklahoma vs. Alabama Odds

• Opening point spread: Alabama -6.5
• Opening moneyline: Alabama TBA/Oklahoma TBA
• Opening total: Over/Under 46.5 points scored
• Time: 3:30 p.m. ET Saturday (ABC)

Before you wager, check out VI's Oklahoma vs. Alabama Best Bet!

EARLY WEEK UPDATE: Borgata Sports drew some action shortly after opening Alabama -7 in college football Week 12 odds.

"We took early respected money on the 'dog at +7 and moved to Alabama -6.5," Borgata sportsbook director Tom Gable said Monday evening. "The Sooners are coming off a bye. The last time we saw them in action, they forced three turnovers and beat Tennessee.

"They probably won’t be able to rely on creating turnovers against Alabama, as the Crimson Tide are among the best in college football in turnovers. Case in point: QB Ty Simpson has only thrown one interception this season."

The Sooners already have two losses, so this matchup is make-or-break.

"With a loss here, Oklahoma will definitely be out of the playoff conversation," Gable said.

The total opened at 46.5 and is at 45.5 Monday evening.

OPENING ODDS UPDATE: Alabama (8-1 SU/6-3 ATS) is on an eight-game win streak (6-2 ATS) since a stunning upset loss at Florida State in Week 1. The Crimson Tide kept rolling in Week 11 with a 20-9 victory over LSU as 10-point home favorites.

Oklahoma (7-2 SU/5-4 ATS) is coming off a bye, after a stretch in which it met three ranked teams in four weeks. The Sooners lost the first two of those three games, on neutral turf vs. Texas and at home vs. Ole Miss.

But Oklahoma went to Tennessee in Week 10 and notched a 33-27 victory catching 3 points.

Circa Sports opened Oklahoma-'Bama at Crimson Tide -6.5 and quickly went to -7 Sunday.

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Virginia vs. Duke Odds

• Opening point spread: Duke -6
• Opening moneyline: Duke TBA/Virginia TBA
• Opening total: Over/Under 58.5 points scored
• Time: 3:30 p.m. ET Saturday (ESPN2)

Need more insight? Check out VI's Virginia vs. Duke Best Bet!

EARLY WEEK UPDATE: Duke opened and remains a 6.5-point favorite in Borgata Sports' Week 12 college football odds.

"The loss of quarterback Chandler Morris for Virginia looms over this game, in what is essentially a loser leaves town match for the ACC. Both teams are coming off of costly losses last week," Borgata sportsbook director Tom Gable said.

Morris is still being evaluated after taking a hit to the head/neck area that forced him out of the Week 11 loss vs. Wake Forest.

Borgata's total is stable at 58.5.

"It’s a high total in this one, and it could certainly turn into a shootout, with the lack of consistency these defenses have displayed," Gable said.

OPENING ODDS UPDATE: Entering Week 11, Virginia (8-2 SU/6-4 ATS) controlled its destiny in the ACC. Not anymore. The Cavaliers closed as 6.5-point home favorites vs. Wake Forest and managed just three field goals while tumbling outright 16-9.

Virginia also lost QB Chandler Morris after he took a hit to the head/neck area. Chandler is still being evaluated, and his status for Week 12 is uncertain. The Cavaliers are in a four-way tie atop the ACC with a 5-1 conference record.

Duke (5-4 SU/4-5 ATS) is actually still in the ACC hunt, despite its middling overall record, because it's 4-1 in conference play. In Week 11, the Blue Devils went to UConn as 7.5-point favorites and left with a 37-34 upset loss.

Duke gave up a touchdown with 1:58 remaining, then drove to UConn's 39-yard line before fumbling the ball away with 18 seconds left.

With Virginia possibly minus Morris, Circa Sports opened Duke as 6-point home chalk in its college football odds Week 12 market. Shortly thereafter on Sunday, the Blue Devils advanced to -6.5.

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Texas vs. Georgia Odds

• Opening point spread: Georgia -5
• Opening moneyline: Georgia TBA/Texas TBA
• Opening total: Over/Under 49.5 points scored
• Time: 7:30 p.m. ET Saturday (ABC)

Don't wager without first reading VI's Texas vs. Georgia Best Bet!

EARLY WEEK UPDATE: The road underdog is getting early attention in Borgata Sports' college football Week 12 odds.

"We opened the Bulldogs as 6.5-point favorites and have seen mostly early Texas money at that number. We are now at Georgia -6," Borgata sportsbook director Tom Gable said Monday evening. "Texas has definitely had their issues on the road this season.

"But both teams' offenses have looked better lately. If Georgia can get this win, it will put the pressure on Alabama and Texas A&M to win out in the SEC."

The total is down to 47.5 from a 48.5 opener.

OPENING ODDS UPDATE: Georgia (8-1 SU/4-5 ATS) enters Week 12 on a five-game win streak (4-1 ATS). The Bulldogs trailed Mississippi State 7-3 in the first quarter, but scored the next 31 points and rolled to a 41-21 victory giving 9.5 points on the road.

Texas (7-2 SU/2-7 ATS) is on a four-game win streak, but is 1-3 ATS in those outings, failing to cover in its last three games. The Longhorns had a bye in Week 11, after fending off Vanderbilt 34-31 as a 3.5-point home favorite in Week 10.

Texas led Vandy 34-10 entering the fourth quarter and nearly gave it away, allowing three touchdowns before holding on to win.

Circa opened Texas-Georgia at Bulldogs -5 and sped to -6.5 within minutes Sunday. After about 20 minutes, Georgia dipped to -6, then resettled at -6.5. The total was also on the move right away, too, going from 49.5 to 47.5.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson