College Football Odds Week 2: Stanford vs USC Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline
USC vs
-28.5 (-110)
+28.5 (-110)
o69.5 (-110)
u69.5 (-110)

College football odds for Week 2 are on the board and receiving plenty of attention as we tackle all the major storylines of the weekend. The Stanford Cardinal and USC Trojans meet at Los Angles Memorial Coliseum in L. A. on Saturday, September 9 at 10:30 p.m. ET on FOX.

Here's everything you need to know about the college football odds for the Week 2 game between Stanford and USC: the opening lines, spreads, betting trends and more. Check back regularly for updates.

Stanford vs No. 6 USC Odds

USC has had plenty of scoring to celebrate over the past two weeks. (Getty)
  • Opening point spread: USC -28.5
  • Opening moneyline: USC TBA/Stanford +TBA
  • Opening total: Over/Under 71 points scored
  • Time: 10:30 p.m. ET Saturday (FOX)

UPDATE 1:30 P.M. ET FRIDAY: BetMGM quickly went from Southern Cal -28.5 to -29.5 Sunday. The Trojans adjusted to -29.5 (-115) on Thursday and are now back at -29 flat.

It's two-way action on the spread, with 51% of tickets on favored USC and 56% of money on big 'dog Stanford.

BetMGM's total initially rose from 70.5 to 71.5 Monday, quickly dialed down to 68.5, then made its way to 70 by this morning. Early ticket count is 5/1 and early money 9/1-plus on the Over.

UPDATE 2 P.M. ET MONDAY: Southern Cal (2-0 SU, 1-1 ATS) has two blowout wins to its credit thus far. In Week 1, the Trojans blasted Nevada 66-14 laying 38.5 points at home.

Stanford (1-0 SU and ATS) closed as a 2.5-point favorite at Hawaii and won 37-24.

A couple hours after Stanford-USC opened Sunday afternoon, Caesars went from Trojans -28.5 to -29.5. The total is stable at 71.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 2 Report containing spreads, lines, and trends for every Top 25 matchup.