College Football Odds Week 4: Duke vs UConn Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline

The college football odds for Week 4 have been unveiled, and we will be exploring all the pivotal storylines of the weekend ahead. Duke travels to UConn on Saturday, September 23 at 3:30 p.m. ET on CBSSN.

Here's everything you need to know about the college football odds for the Week 4 game between Duke vs UConn: the opening lines, spreads, betting trends and more. Check back regularly for updates.

Duke vs. UConn Odds

Duke puts its undefeated record on the line at UConn on Saturday. (Getty)
  • Opening point spread: Duke -22.5
  • Opening moneyline: Duke -2000/UConn +1050
  • Opening total: Over/Under 48 points scored
  • Time: 3:30 p.m. ET Saturday (CBSSN)

UPDATE 1 P.M. ET FRIDAY: Duke has been painted to -21.5 this week at BetMGM, with the only adjustment coming on the juice, which inched to -115 this morning. Home 'dog UConn is getting 56% of spread tickets, while spread money is running almost dead even.

Early moneyline bettors are taking a flier on the +1000 Huskies at BetMGM. Moneyline tickets and cash are 3/1 on UConn.

BetMGM's total opened 46.5 Sunday night, went to 47.5 within a few hours, then steadily fell throughout the week to the current 44.5. The Over is seeing 53% of bets, but 77% of money is on the Under. Rain, potentially heavy, is in the Saturday forecast, along with winds of 10-20 mph.

UPDATE 3:30 P.M. ET MONDAY: Duke (3-0 SU, 2-1 ATS) dispatched Northwestern 38-14 laying 17 points at home in Week 3. Connecticut (0-3 SU, 1-2 ATS) was a 7-point home home favorite against Florida International and lost outright 24-17.

Duke dropped to -21 by this morning at Caesars Sports. The total initially rose to 49, then returned to 48.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 4 Report containing spreads, lines, and trends for every Top 25 matchup.