College Football Odds Week 4: Ole Miss vs Alabama Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline

Week 4 college football odds are posted, and we're prepared to delve into all of the significant storylines of the weekend. Alabama begins SEC play against Mississippi in Tuscaloosa on Saturday, September 23 at 3:30 p.m. ET on CBS.

Here's everything you need to know about the college football odds for the Week 4 game between Mississippi vs Alabama: the opening lines, spreads, betting trends and more. Check back regularly for updates.

Mississippi vs. Alabama Odds

Ole Miss looks to avenge last year's loss to Alabama on Saturday afternoon. (Getty)
  • Opening point spread: Alabama -7
  • Opening moneyline: Alabama -265/Ole Miss +205
  • Opening total: Over/Under 55 points scored
  • Time: 3:30 p.m. ET Saturday (CBS)

UPDATE 1:30 P.M. ET SATURDAY: Alabama has been steady at -7 all week at TwinSpires. That said, spread tickets and money are in the 2/1 range on underdog Mississippi.

"Ole Miss getting 7 vs. struggling Alabama is too to pass up. A very trendy 'dog this week," Lucas said.

The total went from 55 to 56 on two-way play, with 59% of tickets on the Under/56% of money on the Over.

UPDATE 1 P.M. ET FRIDAY: BetMGM has toggled between 'Bama -7 and -6.5 a couple times this week and is currently at -6.5. Early spread tickets and money are almost 2/1 on underdog Ole Miss.

Early bettors like the Rebels even more on the moneyline at BetMGM, with tickets and money beyond 9/1 on the road underdog. Ole Miss is currently +210, while Alabama is -275.

The total went from 55.5 to 56.5 Monday, then peeled back to 54.5 by Wednesday. This morning, BetMGM returned to the 55.5 opener. Ticket count is 2/1 on the Over, but money is running almost dead even.

UPDATE 3:30 P.M. ET MONDAY: Alabama (2-1 SU, 1-2 ATS) seemed to have a Week 3 hangover after its Week 2 home loss to Texas. The Crimson Tide went to South Florida as 34.5-point favorites and found themselves tied 3-3 at halftime.

'Bama went on to an extremely lackluster 17-3 victory and has questions at the quarterback spot. But coach Nick Saban said today Jalen Milroe will start this week.

Meanwhile, Ole Miss is off to a 3-0 SU and ATS start. In Week 3, the Rebels wrecked Georgia Tech 48-23 giving 17 points at home.

TwinSpires hasn't moved off Alabama -7 on its college football Week 3 odds board. But ticket count is 2/1-plus and money almost 2/1 on Mississippi.

"Ole Miss getting 7 vs. struggling Alabama is too good to pass up. Mississippi is a very trendy 'dog this week," Lucas said.

The total is stable at 55, with 55% of tickets/58% of money on the Under early on.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 4 Report containing spreads, lines, and trends for every Top 25 matchup.