2025 College Football Odds Week 5: Lines, Spreads, Betting Trends on Biggest Games

Patrick Everson Sports Betting Expert

5 minute read

The College Football Odds Week 5 market is an absolute gem. Two of the biggest games of the season are on the docket, along with a few more notable games.

The marquee matchups in college football Week 5 odds: No. 6 Oregon vs. No. 2 Penn State, and No. 14 Alabama vs. No. 5 Georgia.

Here’s everything you need to know about college football odds Week 5: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 5 college football odds and action.

Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Imagn Images)

2025 College Football Odds for Week 5

Florida State vs. Virginia Odds

• Opening point spread: Florida State -7
• Opening moneyline: Florida State TBA/Virginia TBA
• Opening total: Over/Under 58.5 points scored
• Time: 7 p.m. ET Friday (ESPN)

OPENING ODDS UPDATE: Florida State (3-0 SU and ATS) followed its Week 1 upset of Alabama with a couple of easy wins vs. overmatched opponents. In Week 4, the Seminoles blasted Kent State 66-10 laying 45.5 points at home.

Virginia (3-1 SU and ATS) had no issues with Stanford in Week 4. The Cavaliers built a 38-14 lead in the third quarter and coasted to a 48-20 victory giving 16.5 points at home.

Circa Sports, which leads the way each Sunday with college football openers, pegged Florida State-Virginia at Seminoles -7 (-115) at 1:30 p.m. ET. The total opened at 58.5, and there was no immediate movement on either number in college football Week 5 odds.

USC vs. Illinois Odds

• Opening point spread: USC -6.5
• Opening moneyline: Illinois TBA/Southern Cal TBA
• Opening total: Over/Under 59.5 points scored
• Time: Noon ET Saturday (FOX)

OPENING ODDS UPDATE: USC (4-0 SU/2-2 ATS) had little trouble dispatching Michigan State 45-31 in Week 4. But the Trojans fell short of cashing as 18.5-point home favorites.

Illinois (3-1 SU and ATS) entered Week 3 Saturday ranked ninth. That'll change dramatically when the new AP poll comes out, after the Illini got boatraced 63-10 as 7-point underdogs at No. 19 Indiana.

Southern Cal opened -6.5 at 1:50 p.m. ET Sunday in Circa Sports' college football odds Week 5 market. The total opened at 59.5.

Notre Dame vs. Arkansas Odds

• Opening point spread: Notre Dame -6
• Opening moneyline: Notre Dame TBA/Arkansas TBA
• Opening total: Over/Under 54.5 points scored
• Time: Noon ET Saturday (ABC)

OPENING ODDS UPDATE: Notre Dame (1-2 SU and ATS) took until Week 4 to notch its first win of the season. The Fighting Irish bounced back from a Week 3 upset loss to Texas A&M by waxing Purdue 56-30 as 24.5-point home favorites.

Arkansas (2-2 SU/1-3 ATS) had a 28-10 lead against Memphis late in the second quarter. But the Razorbacks imploded from there, scoring only 3 points the rest of the way and losing 32-31 as 7.5-point road faves.

Notre Dame opened -6 with a hefty total of 64.5 at Circa Sports.

LSU vs. Ole Miss Odds

• Opening point spread: Ole Miss -1.5
• Opening moneyline: Ole Miss TBA/LSU TBA
• Opening total: Over/Under 56 points scored
• Time: 3:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: LSU (4-0 SU/2-2 ATS) ostensibly had a Week 4 bye, hosting FCS outfit Southeastern Louisiana. The Tigers breezed to a 55-10 victory, falling a little short of the cover as massive 48.5-point favorites.

Ole Miss (4-0 SU/3-1 ATS) returns to SEC play after a tuneup game vs. Tulane in Week 4. The Rebels rolled to a 45-10 victory laying 11.5 points at home.

At 1:55 p.m. ET Sunday, Ole Miss went up as 1.5-point home chalk at Circa Sports, with a total of 56. Within 30 minutes, the line dropped to pick 'em.

Auburn vs. Texas A&M Odds

• Opening point spread: Texas A&M -7.5
• Opening moneyline: Texas A&M TBA/Auburn TBA
• Opening total: Over/Under 51.5 points scored
• Time: 3:30 p.m. ET Saturday (ESPN)

OPENING ODDS UPDATE: Texas A&M (3-0 SU/1-2 ATS) picked a great time to get its first spread cover of the season. In Week 3, the Aggies went to Notre Dame as 6.5-point underdogs and pulled off a 41-40 upset with a touchdown in the waning seconds.

Texas A&M then had a Week 4 bye.

Auburn (3-1 SU/2-2 ATS) was covering much of the game and even led 17-16 midway through the fourth quarter at Oklahoma. But the Tigers gave up a TD – stopping a subsequent 2-point attempt – then took a safety with 1:06 left and lost 24-17 catching 6.5 points.

At 1:55 p.m. ET Sunday, Texas A&M opened as a 7.5-point home favorite in Circa Sports' college football Week 5 odds. The spread dipped to A&M -7 within four minutes. The total opened at 51.5.

Oregon vs. Penn State Odds

• Opening point spread: Penn State -3
• Opening moneyline: Penn State TBA/Oregon TBA
• Opening total: Over/Under 52.5 points scored
• Time: 7:30 p.m. ET Saturday (NBC)

OPENING ODDS UPDATE: Penn State is 3-0 SU, but 0-3 ATS, failing to cover as massive chalk against overmatched opponents. In Week 3, the Nittany Lions led Villanova 52-0 in the waning seconds, then gave up a touchdown on the final play, winning 52-6 as 46.5-point home faves.

Penn State had a bye in Week 4 and should be fresh for this massive Big Ten matchup.

Oregon (4-0 SU/3-1 ATS) did play in Week 4, but it was an easy matchup. The Ducks drilled Oregon State 41-7, narrowly covering as 33.5-point home favorites.

Penn State hit Circa Sports' college football odds Week 5 market as 3-point home chalk, with a total of 52.5. The Nittany Lions quickly went to -3.5 (-105).

Alabama vs. Georgia Odds

• Opening point spread: Georgia -3
• Opening moneyline: Georgia TBA/Alabama TBA
• Opening total: Over/Under 54 points scored
• Time: 7:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: Georgia (3-0 SU/0-3 ATS) probably needed its Week 4 bye, after a thrilling Week 3 win at Tennessee. The Bulldogs turned a 21-7 first-quarter deficit into a shootout, tying it late at 38 to force overtime.

Georgia then won 44-41 in OT, but didn't cover laying 3.5 points.

Alabama (2-1 SU and ATS) also had a Week 4 bye and likely needs all the rest it can get before heading to Athens, Ga. The Crimson Tide can ill afford another early-season loss, after losing at Florida State 31-17 as 13.5-point favorites.

In Week 3, Alabama rolled over Wisconsin 38-14 giving 17 points at home.

At 2 p.m. ET Sunday, Georgia opened -3 in Circa Sports' college football Week 5 odds, with a total of 54. That total dipped to 52.5 in a hurry.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson