College Football Odds Week 5: Iowa State vs Oklahoma Lines, Spreads, Betting Trends
| Matchup | Spread | Total | Moneyline |
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Oklahoma is cruising through the Big 12 so far as the Sooners look to stay unbeaten at home against Iowa State. Coverage begins from Norman on Saturday, September 30 at 7:00 p.m. ET on FOX.
Here's everything you need to know about the college football odds for Week 5 Iowa State vs. Oklahoma: the opening lines, spreads, betting trends and more. Check back regularly for updates.
Iowa State vs No. 14 Oklahoma Odds

- Opening point spread: Oklahoma -20
- Opening moneyline: Oklahoma -1400/Iowa State +800
- Opening total: Over/Under 48.5 points scored
- Time: 7 p.m. ET Saturday (FS1)
UPDATE 2 P.M. ET FRIDAY: The Sooners are pinned to -20 at BetMGM, with the only adjustment coming this morning to -20 (-105). Oklahoma is now back at -20 flat, with tickets 2/1 and money 3/1 on big underdog Iowa State.
Likewise, the total hasn't moved off 48.5 so far. The Over is drawing 54% of bets, while 73% of cash is on the Under.
UPDATE 3 P.M. ET MONDAY: Oklahoma (4-0 SU and ATS) is among just five teams that remain perfect against the oddsmakers. The Sooners just barely covered the number in Week 4, beating Cincinnati 20-6 as 13.5-point favorites.
Iowa State (2-2 SU and ATS) halted a two-game SU and ATS hiccup with a 34-27 home win giving 3.5 points against Oklahoma State.
After opening at Sooners -20, Caesars initially backed up to -19 Sunday afternoon. By this morning, though, the number was up to Oklahoma -21.
Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 5 Report containing spreads, lines, and trends for every Top 25 matchup.
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