College Football Odds Week 5: LSU vs Mississippi Lines, Spreads, Betting Trends
| Matchup | Spread | Total | Moneyline |
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A primetime battle in the SEC takes place in Week 5 of college football as LSU visits Mississippi. Both the Tigers and Rebels enter this contest owning 3-1 records as coverage begins from Vaught-Hemingway Stadium on Saturday, September 30 at 6:00 p.m. ET on ESPN.
Here's everything you need to know about the college football odds for Week 5 LSU vs. Mississippi: the opening lines, spreads, betting trends and more. Check back regularly for updates.
No. 13 LSU vs No. 20 Ole Miss Odds

- Opening point spread: LSU -2.5
- Opening moneyline: LSU -137/Ole Miss +112
- Opening total: Over/Under 63.5 points scored
- Time: 6 p.m. ET Saturday (ESPN)
UPDATE 5:55 P.M. ET SATURDAY: With kickoff approaching, LSU is up to -3 (-105) at BetMGM, after opening and spending most of the week at -2.5. Earlier today, BetMGM reported tickets were 2.5/1 and money 3/1 on the Tigers.
The total shot from 62.5 to 67.5 by Wednesday, then today dipped to 66.5 (Over -115). That noted, it was two-way action earlier today at BetMGM. The latest splits aren't available.
UPDATE 3 P.M. ET THURSDAY: The Tigers have spent most of the week toggling between -2.5 and -3 at PointsBet, save for a short stint Tuesday at -2. LSU is now -2.5 while taking 80% of spread bets/87% of spread dollars.
Some early bettors are eschewing the points and instead betting LSU moneyline, currently -140. Tickets are 3/1 and money beyond 9/1 on the Tigers.
PointsBet's total climbed from 63.5 to 67.5 by Wednesday afternoon. The Over is netting 61% of tickets/82% of money so far.
UPDATE 3 P.M. ET MONDAY: LSU (3-1 SU/2-2 ATS) narrowly avoided what would've been a devastating second loss of the season. Laying 17.5 points against visiting Arkansas, the Tigers needed a final-seconds field goal to win 34-31.
Mississippi (3-1 SU and ATS) won and cashed its first three, but had a tough Week 4 chore at Alabama. The Rebels lost 27-10 catching 7 points.
There's no early spread movement at TwinSpires. But ticket count is 2.5/1 and money 2/1 on the short road chalk Tigers.
"LSU is one of the more popular bets since we opened Week 5 games. LSU moneyline is already seeing 6/1 tickets and 7/1 money," Lucas said.
The total is down a half-point to 63, with 61% of bets on the Over/53% of money on the Under.
"Sharp play on Under 63.5," Lucas said.
Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 5 Report containing spreads, lines, and trends for every Top 25 matchup.
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