2025 College Football Odds Week 6: Lines, Spreads, Betting Trends on Biggest Games

Patrick Everson Sports Betting Expert

4 minute read

The College Football Odds Week 6 market has few notable matchups. That includes one contest involving an SEC team that typically isn't involved in high-profile games.

Vanderbilt visits Alabama, and college football Week 6 odds also include Texas Tech vs. Houston, in a battle of Big 12 unbeatens.

Here’s everything you need to know about college football odds Week 6: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 6 college football odds and action.

Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Will McLelland/Imagn Images)

2025 College Football Odds for Week 6

Kentucky vs. Georgia Odds

• Opening point spread: Georgia -20
• Opening moneyline: Georgia TBA/Kentucky TBA
• Opening total: Over/Under 48.5 points scored
• Time: Noon ET Saturday (ABC)

OPENING ODDS UPDATE: Georgia (3-1 SU/0-4 ATS) still hasn't cashed against the number this season, and now has a its first SU loss, too. In Week 5, the Bulldogs closed as 2.5-point home favorites vs. Alabama and lost outright 24-21.

Perhaps Kentucky (2-2 SU/1-3 ATS) will provide some relief. The Wildcats were 5.5-point road underdogs to South Carolina in Week 5 and got rolled 35-13.

Circa Sports, considered a sharper book and among the first to market each Sunday, opened Georgia as 20-point home chalk in college football Week 6 odds. The Bulldogs almost immediately went to -21. The total opened at 48.5.

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Vanderbilt vs. Alabama Odds

• Opening point spread: Alabama -12
• Opening moneyline: Alabama TBA/Vanderbilt TBA
• Opening total: Over/Under 55.5 points scored
• Time: 3:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: Alabama (3-1 SU and ATS) knocked off No. 5 Georgia 24-21 catching 2.5 points on the road in Week 5. It was an impressive and perhaps needed win for much-maligned coach Kalen DeBoer. And it made up for an Week 1 upset loss at Florida State.

Vanderbilt (5-0 SU/4-1 ATS) had its strong season continue in Week 5. The Commodores rolled over Utah State 55-35, though for the first time this season, they didn't cover while laying 23.5 points at home.

Shortly before 2 p.m. ET Sunday, Alabama opened as 12-point home chalk in Circa Sports' college football odds Week 6 market. The Crimson Tide went to -13 in a hurry, then returned to -12 within 20 minutes or so.

Within 20 minutes, the Crimson Tide dropped straight to -12. The total opened at 55.5.

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Texas Tech vs. Houston Odds

• Opening point spread: Texas Tech -9
• Opening moneyline: Texas Tech TBA/Houston TBA
• Opening total: Over/Under 53.5 points scored
• Time: 7 p.m. ET Saturday (ESPN)

OPENING ODDS UPDATE: Texas Tech (4-0 SU and ATS) had a bye in Week 5, after an impressive Week 4 road victory. The Red Raiders dominated Utah 34-10 as 3.5-point underdogs.

Houston (4-0 SU/3-1 ATS) went to Oregon State as double-digit chalk and found itself in a 14-0 hole early in the second quarter. The Cougars rallied to tie at at 24 with 3:40 left in the fourth quarter, then won 27-24 in overtime giving 12.5 points.

Shortly before 2 p.m. ET, Texas Tech opened -9 in Circa Sports' Week 6 college football odds. The Red Raiders quickly went to -10, then onto -11 before settling at -10.5 after 20 minutes. The total opened at 53.5 and dropped to 51 in short order.

Minnesota vs. Ohio State Odds

• Opening point spread: Ohio State -22
• Opening moneyline: Ohio State TBA/Minnesota TBA
• Opening total: Over/Under 46.5 points scored
• Time: 7:30 p.m. ET Saturday (NBC)

OPENING ODDS UPDATE: Ohio State (4-0 SU/3-0-1 ATS) muddled through the first half at Washington, taking a 7-3 lead into the locker room. But the Buckeyes got going in the second half and breezed to a 24-6 victory laying 9.5 points.

Minnesota (3-1 SU/1-3 ATS) got a much stiffer Week 5 challenge from Rutgers. The Golden Gophers trailed 14-0 early in the second quarter, then rallied to tie it just a few minutes later.

It was back-and-forth from there, with Minnesota winning 31-28 on a touchdown with 3:19 remaining. But the Gophers failed to cash as 3.5-point home favorites.

Minnesota-Ohio State was quickly on the move in Circa Sports' college football odds Week 6 market. The Buckeyes opened -22 at 1:44 p.m. ET Sunday and quickly went to -24. On the flip side, the total dipped from 46.5 to 44.5.

Mississippi State vs. Texas A&M Odds

• Opening point spread: Texas A&M -12
• Opening moneyline: Texas A&M TBA/Mississippi State TBA
• Opening total: Over/Under 56.5 points scored
• Time: 7:30 p.m. ET Saturday (SEC Network)

OPENING ODDS UPDATE: Texas A&M (4-0 SU/1-3 ATS) remained unbeaten in an offensively challenged game vs. Auburn. The Red Raiders hung on for a 16-10 victory, but failed to cash as 6.5-point home favorites in Week 5.

Meanwhile, Mississippi State (4-1 SU/5-0 ATS) almost pulled off a Week 5 upset in a back-and-forth battle with then-No. 15 Tennessee. The Bulldogs led 34-27 late, but gave up a touchdown with 1:55 remaining. Mississippi State then lost 41-34 catching 7.5 points at home.

Circa Sports opened Texas A&M as 12-point home chalk in college football Week 6 odds, at 2 p.m. ET Sunday. That didn't last long, as the Aggies sped out to -13.5. The total opened at 56.5 and just as quickly ran out to 59.

Miami vs. Florida State Odds

• Opening point spread: Miami -5
• Opening moneyline: Florida State TBA/Miami TBA
• Opening total: Over/Under 54.5 points scored
• Time: 7:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: Florida State (3-1 SU and ATS) took its first loss of the season in a high-flying affair at Virginia. The Seminoles erased a 14-0 deficit, ultimately forcing overtime tied at 35. But Florida State fell 45-38 in double OT as 7-point road chalk.

Miami (4-0 SU/3-1 ATS) had a bye in Week 5. The Hurricanes rolled over Florida 26-7 laying 8.5 points at home in Week 4.

Circa Sports opened Miami -5 just before 2 p.m. ET Sunday, and the line quickly went to -6, then returned to -5. The total opened at 54.5 in the college football odds Week 6 market.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson