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Featured Last Updated Sep 25 2025, 2:20 PM

Indiana vs. Iowa: Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
Indiana vs. Iowa: Prediction, Odds, Best Bet

Image Credit: Rich Janzaruk via Imagn Images

IU @ IOWA Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Indiana Hoosiers 133 Indiana
-3 -115 -4 -110 + -4 -120 + -4.5 even + -4 -110 + -4.5 -105 + -4.5 -110 + -4.5 even -4.5 -104 + -4.5 -104 -8.5 -105  
Iowa Hawkeyes 134 Iowa
+3 -105 +4 -110 + +4 even + +4.5 -120 + +4 -110 + +4.5 -125 + +4.5 -110 + +4.5 -120 +4.5 -121 + +4.5 -121 +8.5 -115  
Indiana Hoosiers 133 Indiana
o50.5 -110 o23.5 -120 + N/A o23.5 -125 + o23.5 -120 + N/A o24.5 +114 + o22.5 -135 o23.5 -117 + o23.5 -117 o47.5 -115  
Iowa Hawkeyes 134 Iowa
u50.5 -110 u23.5 even + N/A u23.5 +105 + u23.5 even + N/A u24.5 -140 + u22.5 +110 u23.5 -112 + u23.5 -112 u47.5 -105  
Indiana Hoosiers 133 Indiana
-265 -230 + N/A -245 + -235 + -260 + -245 + N/A -240 + -240 -298  
Iowa Hawkeyes 134 Iowa
+215 +190 + N/A +200 + +196 + +190 + +198 + N/A +180 + +180 +250  
Indiana Hoosiers 133 Indiana
-3 -115 -3 even + -1.5 -110 + -2.5 -112 + -2.5 -115 + N/A -1.5 -112 + -2.5 -115 -2.5 -114 + -2.5 -114 -8.5 -105  
Iowa Hawkeyes 134 Iowa
+3 -105 +3 -130 + +1.5 -120 + +2.5 -108 + +2.5 -115 + N/A +1.5 -114 + +2.5 -115 +2.5 -114 + +2.5 -114 +8.5 -115  
Indiana Hoosiers 133 Indiana
o50.5 -110 o10.5 even + N/A o10.5 +105 + o10.5 even + N/A o9.5 -140 + o10.5 even o10.5 +105 + o10.5 +105 o47.5 -115  
Iowa Hawkeyes 134 Iowa
u50.5 -110 u10.5 -130 + N/A u10.5 -125 + u10.5 -130 + N/A u9.5 +116 + u10.5 -135 u10.5 -136 + u10.5 -136 u47.5 -105  
Indiana Hoosiers 133 Indiana
-265 -180 + N/A -180 + -180 + N/A -205 + N/A -200 + -200 -298  
Iowa Hawkeyes 134 Iowa
+215 +145 + N/A +150 + +150 + N/A +162 + N/A +150 + +150 +250  
Indiana Hoosiers 133 Indiana
-3 -115 N/A N/A -3.5 -118 + -3.5 -120 + N/A N/A N/A N/A N/A -8.5 -105  
Iowa Hawkeyes 134 Iowa
+3 -105 N/A N/A +3.5 -102 + +3.5 even + N/A N/A N/A N/A N/A +8.5 -115  
Indiana Hoosiers 133 Indiana
o50.5 -110 N/A N/A o23.5 -102 + o23.5 -105 + N/A N/A N/A N/A N/A o47.5 -115  
Iowa Hawkeyes 134 Iowa
u50.5 -110 N/A N/A u23.5 -118 + u23.5 -115 + N/A N/A N/A N/A N/A u47.5 -105  
Indiana Hoosiers 133 Indiana
-265 N/A N/A -225 + N/A N/A N/A N/A N/A N/A -298  
Iowa Hawkeyes 134 Iowa
+215 N/A N/A +185 + N/A N/A N/A N/A N/A N/A +250  
Indiana Hoosiers 133 Indiana
-3 -115 N/A N/A -2.5 -120 + N/A N/A -2.5 -136 + N/A N/A N/A -8.5 -105  
Iowa Hawkeyes 134 Iowa
+3 -105 N/A N/A +2.5 -110 + N/A N/A +2.5 +102 + N/A N/A N/A +8.5 -115  
Indiana Hoosiers 133 Indiana
o50.5 -110 o13.5 -115 + N/A o13.5 -105 + N/A N/A o13.5 -128 + N/A N/A N/A o47.5 -115  
Iowa Hawkeyes 134 Iowa
u50.5 -110 u13.5 -115 + N/A u13.5 -125 + N/A N/A u13.5 +102 + N/A N/A N/A u47.5 -105  
Indiana Hoosiers 133 Indiana
-265 -225 + N/A -200 + N/A N/A -215 + N/A N/A N/A -298  
Iowa Hawkeyes 134 Iowa
+215 +175 + N/A +154 + N/A N/A +164 + N/A N/A N/A +250  
Indiana Hoosiers 133 Indiana
-3 -115 N/A N/A -1.5 -115 + N/A N/A -2.5 -122 + N/A N/A N/A -8.5 -105  
Iowa Hawkeyes 134 Iowa
+3 -105 N/A N/A +1.5 -115 + N/A N/A +2.5 -106 + N/A N/A N/A +8.5 -115  
Indiana Hoosiers 133 Indiana
o50.5 -110 o10 -115 + N/A o9.5 -130 + N/A N/A o10.5 +112 + N/A N/A N/A o47.5 -115  
Iowa Hawkeyes 134 Iowa
u50.5 -110 u10 -115 + N/A u9.5 even + N/A N/A u10.5 -142 + N/A N/A N/A u47.5 -105  
Indiana Hoosiers 133 Indiana
-265 -200 + N/A -210 + N/A N/A -220 + N/A N/A N/A -298  
Iowa Hawkeyes 134 Iowa
+215 +160 + N/A +160 + N/A N/A +176 + N/A N/A N/A +250  
Indiana Hoosiers 133 Indiana
-3 -115 -0.5 -110 + N/A -1.5 -110 + N/A N/A -1.5 -110 + N/A N/A N/A -8.5 -105  
Iowa Hawkeyes 134 Iowa
+3 -105 +0.5 -120 + N/A +1.5 -120 + N/A N/A +1.5 -120 + N/A N/A N/A +8.5 -115  
Indiana Hoosiers 133 Indiana
o50.5 -110 o12.5 -115 + N/A o13.5 -105 + N/A N/A o12.5 -118 + N/A N/A N/A o47.5 -115  
Iowa Hawkeyes 134 Iowa
u50.5 -110 u12.5 -115 + N/A u13.5 -125 + N/A N/A u12.5 -106 + N/A N/A N/A u47.5 -105  
Indiana Hoosiers 133 Indiana
-265 -170 + N/A -180 + N/A N/A -186 + N/A N/A N/A -298  
Iowa Hawkeyes 134 Iowa
+215 +140 + N/A +140 + N/A N/A +146 + N/A N/A N/A +250  

The Indiana Hoosiers will take on the Iowa Hawkeyes in this week's NCAAF action. Kickoff is set for 3:30 p.m. EDT at Kinnick Stadium in Iowa City, Iowa. The game will be broadcast live on Peacock. Here's everything you need to know about Indiana vs. Iowa odds, the latest NFL spreads, NFL over/unders and more.

The Indiana Hoosiers opened as a -7.5 point favorite over Iowa. The total is set at over/under 48.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Indiana Hoosiers vs. Iowa Hawkeyes Best Bet

Indiana had one of the more epic beatdowns of the 2025 NCAAF regular season to start.

IU QB Fernando Mendoza was absolutely dealing and a front 7 that is one of the best in terms of creating havoc, was in the backfield all night.

Now, they head to Iowa City to take on a pesky Hawkeyes team that is coming off a solid road win in Piscataway, NJ last Friday night.

Unlike other Iowa teams in the past, this iteration of the Hawkeyes can put up some points. Although some of their opponents were lackluster, they've managed to put up 34+ points in three of their four games.

They also have one of the nation's best ground attacks, which can help neutralize Indiana's terrorizing front.

This will be a tough spot for IU to get up for - I like the Hawkeyes to keep it close at home.

Indiana vs. Iowa Best Bet: Iowa +7.5

(Pick from Derek Mountain)

Looking for more best bets? Check out our free college football picks and our premium subscription for the best picks!

What Time Indiana Hoosiers vs. Iowa Hawkeyes Game?

The Indiana Hoosiers will take on the Iowa Hawkeyes at 3:30 ET on Saturday, September 27th.

Where is the Indiana Hoosiers vs. Iowa Hawkeyes Game Being Played?

This game is going to be played at Kinnick Stadium in Iowa City, Iowa.

How Can I Watch Indiana vs. Iowa?

You can watch Indiana vs. Iowa on Peacock.

Can Iowa Beat Indiana?

Yes, in fact the Vegas oddsmakers certainly think so as this spread opened at 7.5 points and is down all the way to just 3.5 points.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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