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Featured Last Updated Nov 14 2025, 10:06 AM

Iowa vs. USC: Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
Iowa vs. USC: Prediction, Odds, Best Bet

Image Credit: Jeffrey Becker via Imagn Images

IOWA @ USC Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Iowa Hawkeyes 401 Iowa
+6.5 -110 +3.5 -110 + +3.5 -105 + +3.5 -112 + +3.5 -110 + +3.5 -105 + +3.5 -105 + +3.5 -115 +3.5 -113 + +6.5 -108  
USC Trojans 402 USC
-6.5 -110 -3.5 -110 + -3.5 -115 + -3.5 -108 + -3.5 -110 + -3.5 -115 + -3.5 -115 + -3.5 -115 -3.5 -115 + -6.5 -112  
Iowa Hawkeyes 401 Iowa
o49.5 -110 o24 even + o24.5 even + o24.5 -102 + o24 -105 + o24.5 +104 + o24.5 even + o24.5 even o23.5 -132 + o48.5 -112  
USC Trojans 402 USC
u49.5 -110 u24 -120 + u24.5 -120 + u24.5 -118 + u24 -115 + u24.5 -124 + u24.5 -120 + u24.5 -130 u23.5 +102 + u48.5 -108  
Iowa Hawkeyes 401 Iowa
+185 +165 + +155 + +164 + +162 + +160 + N/A N/A +150 + +200  
USC Trojans 402 USC
-225 -200 + -190 + -198 + -195 + -194 + N/A N/A -200 + -245  
Iowa Hawkeyes 401 Iowa
+6.5 -110 +0.5 even + +2.5 +105 + +3.5 -130 + +0.5 even + +1.5 -118 + +2.5 -115 + +2.5 even +1.5 -125 + +6.5 -108  
USC Trojans 402 USC
-6.5 -110 -0.5 -130 + -2.5 -135 + -3.5 even + -0.5 -130 + -1.5 -106 + -2.5 -115 + -2.5 -130 -1.5 -104 + -6.5 -112  
Iowa Hawkeyes 401 Iowa
o49.5 -110 o10 -115 + o9.5 -130 + o10.5 +105 + o10 -115 + o10.5 +118 + o10.5 -105 + o10.5 +115 o10.5 +114 + o48.5 -112  
USC Trojans 402 USC
u49.5 -110 u10 -115 + u9.5 even + u10.5 -135 + u10 -115 + u10.5 -148 + u10.5 -125 + u10.5 -150 u10.5 -148 + u48.5 -108  
Iowa Hawkeyes 401 Iowa
+185 +150 + +145 + +165 + +155 + +146 + N/A N/A +132 + +200  
USC Trojans 402 USC
-225 -185 + -190 + -215 + -190 + -188 + N/A N/A -175 + -245  
Iowa Hawkeyes 401 Iowa
+6.5 -110 N/A N/A +3.5 -120 + +2.5 -105 + N/A N/A N/A N/A +6.5 -108  
USC Trojans 402 USC
-6.5 -110 N/A N/A -3.5 even + -2.5 -115 + N/A N/A N/A N/A -6.5 -112  
Iowa Hawkeyes 401 Iowa
o49.5 -110 N/A N/A o23.5 -108 + o23.5 -115 + N/A o23.5 -120 + N/A N/A o48.5 -112  
USC Trojans 402 USC
u49.5 -110 N/A N/A u23.5 -112 + u23.5 -105 + N/A u23.5 -110 + N/A N/A u48.5 -108  
Iowa Hawkeyes 401 Iowa
+185 N/A N/A +154 + N/A N/A N/A N/A N/A +200  
USC Trojans 402 USC
-225 N/A N/A -180 + N/A N/A N/A N/A N/A -245  
Iowa Hawkeyes 401 Iowa
+6.5 -110 N/A N/A +0.5 -145 + N/A +2.5 -120 + +0.5 -115 + N/A N/A +6.5 -108  
USC Trojans 402 USC
-6.5 -110 N/A N/A -0.5 +114 + N/A -2.5 -110 + -0.5 -115 + N/A N/A -6.5 -112  
Iowa Hawkeyes 401 Iowa
o49.5 -110 o13.5 -120 + N/A o13.5 -115 + N/A o13.5 -122 + o13.5 -115 + N/A N/A o48.5 -112  
USC Trojans 402 USC
u49.5 -110 u13.5 -110 + N/A u13.5 -115 + N/A u13.5 -102 + u13.5 -115 + N/A N/A u48.5 -108  
Iowa Hawkeyes 401 Iowa
+185 +135 + N/A +105 + N/A +134 + N/A N/A N/A +200  
USC Trojans 402 USC
-225 -160 + N/A -135 + N/A -174 + N/A N/A N/A -245  
Iowa Hawkeyes 401 Iowa
+6.5 -110 N/A N/A +0.5 -120 + N/A +1.5 -132 + +0.5 -125 + N/A N/A +6.5 -108  
USC Trojans 402 USC
-6.5 -110 N/A N/A -0.5 -110 + N/A -1.5 -100 + -0.5 -105 + N/A N/A -6.5 -112  
Iowa Hawkeyes 401 Iowa
o49.5 -110 o10.5 -115 + N/A o9.5 -135 + N/A o10.5 +122 + o9.5 -135 + N/A N/A o48.5 -112  
USC Trojans 402 USC
u49.5 -110 u10.5 -115 + N/A u9.5 +105 + N/A u10.5 -152 + u9.5 +105 + N/A N/A u48.5 -108  
Iowa Hawkeyes 401 Iowa
+185 +150 + N/A +130 + N/A +138 + N/A N/A N/A +200  
USC Trojans 402 USC
-225 -180 + N/A -166 + N/A -178 + N/A N/A N/A -245  
Iowa Hawkeyes 401 Iowa
+6.5 -110 +0.5 -130 + N/A +0.5 -115 + N/A +1.5 -138 + +0.5 -135 + N/A N/A +6.5 -108  
USC Trojans 402 USC
-6.5 -110 -0.5 even + N/A -0.5 -115 + N/A -1.5 +106 + -0.5 +105 + N/A N/A -6.5 -112  
Iowa Hawkeyes 401 Iowa
o49.5 -110 o13.5 -115 + N/A o13.5 -110 + N/A o12.5 -128 + o13.5 -115 + N/A N/A o48.5 -112  
USC Trojans 402 USC
u49.5 -110 u13.5 -115 + N/A u13.5 -120 + N/A u12.5 +102 + u13.5 -115 + N/A N/A u48.5 -108  
Iowa Hawkeyes 401 Iowa
+185 +135 + N/A +124 + N/A +124 + N/A N/A N/A +200  
USC Trojans 402 USC
-225 -160 + N/A -160 + N/A -154 + N/A N/A N/A -245  

The Iowa Hawkeyes will take on the USC Trojans in this week's NCAAF action. Kickoff is set for 3:30 p.m. EST at Los Angeles Memorial Coliseum in Los Angeles, Calif. The game will be broadcast live on BTN. Here's everything you need to know about Iowa vs. USC odds, the latest NFL spreads, NFL over/unders and more.

The USC Trojans opened as a -6.5 point favorite over Iowa. The total is set at over/under 48.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 11/14/25

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Iowa vs. USC Best Bet

In a pivotal Big Ten matchup, the Trojans will look to keep their CFP hopes alive. The Trojans ranked #17 in the latest College Football Playoff rankings and will look to continue to climb against a tough Iowa squad that was a minute away from upsetting Oregon a week ago.

This is an obvious letdown spot for Iowa coming off such a devastating loss, but on the other side, this is a matchup Kirk Ferentz and co. salivate over.

Lincoln Riley teams aren't usually known for taking care of big, physical teams like Iowa that like to slow it down and can take over a game from the line of scrimmage.

Although this game is in Southern Cal., rain is in the forecast which should favor Iowa.

So, instead of attacking a tricky spread, let's take the under here. A sleepy spot for Iowa, compounded with a tough matchup on paper for the Trojans, could produce a slugfest.

Iowa vs. USC Best Bet: Under 49.5 (-105)

(Pick from Derek Mountain)

Looking for more best bets? Check out our free college football picks and our premium subscription for the best picks!

What Time is the Iowa vs. USC Game?

The Iowa Hawkeyes will take on the USC Trojans at 3:30 PM EDT.

Where is the Iowa vs. USC Game Being Played?

This game is going to be played at Los Angeles Memorial Coliseum in Los Angeles, California.

How Can I Watch Iowa vs. USC?

You can watch Iowa vs. USC on the Big Ten Network.

Can Iowa Beat USC?

Yes, Iowa was on the verge of a major upset in Iowa City last week against the Oregon Ducks and look to complete it the job this Saturday in LA.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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