Iowa vs. USC: Prediction, Odds, Best Bet
Image Credit: Jeffrey Becker via Imagn Images
IOWA @ USC Odds
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Final | Open | | | | | | | | | | |
| | +6.5 -110 | +6.5 -105 | +5.5 even | +6.5 -115 | +6.5 -110 | +6.5 -106 | +6.5 -110 | +6.5 even | +6.5 -107 | +6.5 -115 | |
| | -6.5 -110 | -6.5 -115 | -5.5 -130 | -6.5 -115 | -6.5 -110 | -6.5 -114 | -6.5 -110 | -6.5 -120 | -6.5 -117 | -6.5 -115 | |
| Final | Open | | | | | | | | | | |
| | o49.5 -110 | o48.5 -110 | o48.5 -105 | o49.5 -110 | o48.5 -110 | o48.5 -110 | o48.5 -110 | o48.5 -110 | o48.5 -114 | o49.5 -110 | |
| | u49.5 -110 | u48.5 -110 | u48.5 -115 | u49.5 -120 | u48.5 -110 | u48.5 -110 | u48.5 -110 | u48.5 -110 | u48.5 -109 | u49.5 -120 | |
| Final | Open | | | | | | | | | | |
| | +185 | +195 | +200 | +185 | +192 | +198 | +175 | +190 | +185 | +185 | |
| | -225 | -240 | -250 | -245 | -235 | -230 | -230 | -235 | -250 | -245 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Final | Open | | | | | | | | | | |
| | +6.5 -110 | +3.5 -105 | +3.5 -105 | +3.5 -115 | +3.5 -105 | +3.5 -106 | +3.5 -115 | +3.5 -115 | +3.5 -121 | +6.5 -115 | |
| | -6.5 -110 | -3.5 -115 | -3.5 -115 | -3.5 -115 | -3.5 -115 | -3.5 -114 | -3.5 -115 | -3.5 -115 | -3.5 -103 | -6.5 -115 | |
| Final | Open | | | | | | | | | | |
| | o49.5 -110 | o24 -110 | o23.5 -125 | o24.5 -105 | o24 -110 | o24.5 +108 | o23.5 -130 | o24.5 +105 | o23.5 -129 | o49.5 -110 | |
| | u49.5 -110 | u24 -110 | u23.5 +105 | u24.5 -125 | u24 -110 | u24.5 -130 | u23.5 even | u24.5 -140 | u23.5 -103 | u49.5 -120 | |
| Final | Open | | | | | | | | | | |
| | +185 | +170 | +155 | +165 | +175 | +168 | N/A | N/A | +138 | +185 | |
| | -225 | -200 | -190 | -218 | -205 | -205 | N/A | N/A | -180 | -245 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Final | Open | | | | | | | | | | |
| | +6.5 -110 | +0.5 even | +2.5 +105 | +2.5 -115 | +0.5 even | +1.5 -114 | +0.5 -130 | +2.5 -105 | +1.5 -152 | +6.5 -115 | |
| | -6.5 -110 | -0.5 -130 | -2.5 -140 | -2.5 -115 | -0.5 -130 | -1.5 -110 | -0.5 even | -2.5 -125 | -1.5 +116 | -6.5 -115 | |
| Final | Open | | | | | | | | | | |
| | o49.5 -110 | o10 -115 | o9.5 -125 | o10.5 +105 | o10 -115 | o10.5 +124 | o9.5 -150 | o10.5 +120 | o9.5 -152 | o49.5 -110 | |
| | u49.5 -110 | u10 -115 | u9.5 -105 | u10.5 -135 | u10 -115 | u10.5 -152 | u9.5 +115 | u10.5 -160 | u9.5 +116 | u49.5 -120 | |
| Final | Open | | | | | | | | | | |
| | +185 | +150 | +150 | +140 | +155 | +154 | N/A | N/A | +110 | +185 | |
| | -225 | -185 | -200 | -182 | -190 | -200 | N/A | N/A | -143 | -245 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Final | Open | | | | | | | | | | |
| | +6.5 -110 | N/A | N/A | +2.5 -110 | +3.5 -125 | N/A | N/A | N/A | N/A | +6.5 -115 | |
| | -6.5 -110 | N/A | N/A | -2.5 -120 | -3.5 +105 | N/A | N/A | N/A | N/A | -6.5 -115 | |
| Final | Open | | | | | | | | | | |
| | o49.5 -110 | N/A | N/A | o23.5 -120 | o23.5 -110 | N/A | o23.5 -125 | N/A | N/A | o49.5 -110 | |
| | u49.5 -110 | N/A | N/A | u23.5 -110 | u23.5 -110 | N/A | u23.5 -105 | N/A | N/A | u49.5 -120 | |
| Final | Open | | | | | | | | | | |
| | +185 | N/A | N/A | +140 | N/A | N/A | N/A | N/A | N/A | +185 | |
| | -225 | N/A | N/A | -182 | N/A | N/A | N/A | N/A | N/A | -245 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Final | Open | | | | | | | | | | |
| | +6.5 -110 | N/A | N/A | +0.5 -110 | N/A | +1.5 -120 | +0.5 -115 | N/A | N/A | +6.5 -115 | |
| | -6.5 -110 | N/A | N/A | -0.5 -120 | N/A | -1.5 -110 | -0.5 -115 | N/A | N/A | -6.5 -115 | |
| Final | Open | | | | | | | | | | |
| | o49.5 -110 | o14 -115 | N/A | o13.5 -110 | N/A | o21.5 +125 | o13.5 -110 | N/A | N/A | o49.5 -110 | |
| | u49.5 -110 | u14 -115 | N/A | u13.5 -120 | N/A | u21.5 -160 | u13.5 -120 | N/A | N/A | u49.5 -120 | |
| Final | Open | | | | | | | | | | |
| | +185 | +135 | N/A | +126 | N/A | +132 | N/A | N/A | N/A | +185 | |
| | -225 | -160 | N/A | -162 | N/A | -174 | N/A | N/A | N/A | -245 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Final | Open | | | | | | | | | | |
| | +6.5 -110 | N/A | N/A | +0.5 -110 | N/A | +1.5 -130 | +0.5 -120 | N/A | N/A | +6.5 -115 | |
| | -6.5 -110 | N/A | N/A | -0.5 -120 | N/A | -1.5 -102 | -0.5 -110 | N/A | N/A | -6.5 -115 | |
| Final | Open | | | | | | | | | | |
| | o49.5 -110 | o10 -115 | N/A | o9.5 -135 | N/A | o8.5 -144 | o9.5 -140 | N/A | N/A | o49.5 -110 | |
| | u49.5 -110 | u10 -115 | N/A | u9.5 +105 | N/A | u8.5 +110 | u9.5 +110 | N/A | N/A | u49.5 -120 | |
| Final | Open | | | | | | | | | | |
| | +185 | +160 | N/A | +145 | N/A | +142 | N/A | N/A | N/A | +185 | |
| | -225 | -200 | N/A | -188 | N/A | -178 | N/A | N/A | N/A | -245 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Final | Open | | | | | | | | | | |
| | +6.5 -110 | +0.5 -125 | N/A | +0.5 -125 | N/A | +1.5 -136 | +0.5 -130 | N/A | N/A | +6.5 -115 | |
| | -6.5 -110 | -0.5 -105 | N/A | -0.5 -105 | N/A | -1.5 +102 | -0.5 even | N/A | N/A | -6.5 -115 | |
| Final | Open | | | | | | | | | | |
| | o49.5 -110 | o12.5 -115 | N/A | o13.5 -115 | N/A | o12.5 -128 | o13.5 -125 | N/A | N/A | o49.5 -110 | |
| | u49.5 -110 | u12.5 -115 | N/A | u13.5 -115 | N/A | u12.5 +102 | u13.5 -105 | N/A | N/A | u49.5 -120 | |
| Final | Open | | | | | | | | | | |
| | +185 | +145 | N/A | +105 | N/A | +122 | N/A | N/A | N/A | +185 | |
| | -225 | -180 | N/A | -135 | N/A | -160 | N/A | N/A | N/A | -245 | |
The Iowa Hawkeyes will take on the USC Trojans in this week's NCAAF action. Kickoff is set for 3:30 p.m. EST at Los Angeles Memorial Coliseum in Los Angeles, Calif. The game will be broadcast live on BTN. Here's everything you need to know about Iowa vs. USC odds, the latest NFL spreads, NFL over/unders and more.
The USC Trojans opened as a -6.5 point favorite over Iowa. The total is set at over/under 48.5 total points scored by both teams combined.
Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!
Updated on 12/30/25

Iowa vs. USC Best Bet
In a pivotal Big Ten matchup, the Trojans will look to keep their CFP hopes alive. The Trojans ranked #17 in the latest College Football Playoff rankings and will look to continue to climb against a tough Iowa squad that was a minute away from upsetting Oregon a week ago.
This is an obvious letdown spot for Iowa coming off such a devastating loss, but on the other side, this is a matchup Kirk Ferentz and co. salivate over.
Lincoln Riley teams aren't usually known for taking care of big, physical teams like Iowa that like to slow it down and can take over a game from the line of scrimmage.
Although this game is in Southern Cal., rain is in the forecast which should favor Iowa.
So, instead of attacking a tricky spread, let's take the under here. A sleepy spot for Iowa, compounded with a tough matchup on paper for the Trojans, could produce a slugfest.
Iowa vs. USC Best Bet: Under 49.5 (-105)
(Pick from Derek Mountain)
Looking for more best bets? Check out our free college football picks and our premium subscription for the best picks!
What Time is the Iowa vs. USC Game?
The Iowa Hawkeyes will take on the USC Trojans at 3:30 PM EDT.
Where is the Iowa vs. USC Game Being Played?
This game is going to be played at Los Angeles Memorial Coliseum in Los Angeles, California.
How Can I Watch Iowa vs. USC?
You can watch Iowa vs. USC on the Big Ten Network.
Can Iowa Beat USC?
Yes, Iowa was on the verge of a major upset in Iowa City last week against the Oregon Ducks and look to complete it the job this Saturday in LA.
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