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Featured Last Updated Sep 26 2025, 11:00 AM

LSU vs. Ole Miss: Prediction, Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
LSU vs. Ole Miss: Prediction, Odds, Best Bet

Image Credit: Petre Thomas-Imagn Images

LSU @ MISS Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
LSU Tigers 175 LSU
+2.5 -110 +0.5 -110 + +0.5 -115 + +0.5 -108 + +0.5 -110 + +0.5 -115 + +1.5 -124 + +0.5 -120 +1.5 -120 + +1.5 -108  
Ole Miss Rebels 176 Ole Miss
-2.5 -110 -0.5 -110 + -0.5 -105 + -0.5 -112 + -0.5 -110 + -0.5 -115 + -1.5 +102 + -0.5 even -1.5 -105 + -1.5 -112  
LSU Tigers 175 LSU
o56.5 -110 o27.5 -105 + N/A o28.5 -105 + o27.5 -110 + N/A o29.5 +102 + o27.5 -110 o27.5 -122 + o57.5 -110  
Ole Miss Rebels 176 Ole Miss
u56.5 -110 u27.5 -115 + N/A u28.5 -115 + u27.5 -110 + N/A u29.5 -124 + u27.5 -110 u27.5 -107 + u57.5 -110  
LSU Tigers 175 LSU
-125 +105 + N/A +105 + +105 + even + +104 + N/A -104 + +102  
Ole Miss Rebels 176 Ole Miss
+105 -125 + N/A -125 + -125 + -130 + -128 + N/A -125 + -125  
LSU Tigers 175 LSU
+2.5 -110 +0.5 -145 + +0.5 -150 + +0.5 -135 + +0.5 -140 + N/A +1.5 -158 + -0.5 +140 +1.5 -167 + +1.5 -108  
Ole Miss Rebels 176 Ole Miss
-2.5 -110 -0.5 +115 + -0.5 +115 + -0.5 +114 + -0.5 +110 + N/A -1.5 +126 + +0.5 -195 -1.5 +128 + -1.5 -112  
LSU Tigers 175 LSU
o56.5 -110 o12.5 -115 + N/A o12.5 -108 + o12.5 -115 + N/A o13.5 -104 + o10.5 -115 o12.5 -121 + o57.5 -110  
Ole Miss Rebels 176 Ole Miss
u56.5 -110 u12.5 -115 + N/A u12.5 -112 + u12.5 -115 + N/A u13.5 -120 + u10.5 -115 u12.5 -109 + u57.5 -110  
LSU Tigers 175 LSU
-125 -110 + N/A -102 + even + N/A +102 + N/A -104 + +102  
Ole Miss Rebels 176 Ole Miss
+105 -120 + N/A -118 + -130 + N/A -130 + N/A -125 + -125  
LSU Tigers 175 LSU
+2.5 -110 N/A N/A +1.5 -142 + -0.5 +105 + N/A N/A N/A N/A +1.5 -108  
Ole Miss Rebels 176 Ole Miss
-2.5 -110 N/A N/A -1.5 +120 + +0.5 -125 + N/A N/A N/A N/A -1.5 -112  
LSU Tigers 175 LSU
o56.5 -110 N/A N/A o28.5 +102 + o27.5 -115 + N/A N/A N/A N/A o57.5 -110  
Ole Miss Rebels 176 Ole Miss
u56.5 -110 N/A N/A u28.5 -122 + u27.5 -105 + N/A N/A N/A N/A u57.5 -110  
LSU Tigers 175 LSU
-125 N/A N/A -108 + N/A N/A N/A N/A N/A +102  
Ole Miss Rebels 176 Ole Miss
+105 N/A N/A -112 + N/A N/A N/A N/A N/A -125  
LSU Tigers 175 LSU
+2.5 -110 N/A N/A +0.5 -135 + N/A N/A +1.5 -154 + N/A N/A +1.5 -108  
Ole Miss Rebels 176 Ole Miss
-2.5 -110 N/A N/A -0.5 +105 + N/A N/A -1.5 +116 + N/A N/A -1.5 -112  
LSU Tigers 175 LSU
o56.5 -110 o16.5 -120 + N/A o16.5 -110 + N/A N/A o16.5 -118 + N/A N/A o57.5 -110  
Ole Miss Rebels 176 Ole Miss
u56.5 -110 u16.5 -110 + N/A u16.5 -120 + N/A N/A u16.5 -106 + N/A N/A u57.5 -110  
LSU Tigers 175 LSU
-125 -115 + N/A -105 + N/A N/A -104 + N/A N/A +102  
Ole Miss Rebels 176 Ole Miss
+105 -115 + N/A -125 + N/A N/A -122 + N/A N/A -125  
LSU Tigers 175 LSU
+2.5 -110 N/A N/A +0.5 -166 + N/A N/A -1.5 +124 + N/A N/A +1.5 -108  
Ole Miss Rebels 176 Ole Miss
-2.5 -110 N/A N/A -0.5 +130 + N/A N/A +1.5 -166 + N/A N/A -1.5 -112  
LSU Tigers 175 LSU
o56.5 -110 o13.5 -115 + N/A o13.5 -115 + N/A N/A o13.5 -114 + N/A N/A o57.5 -110  
Ole Miss Rebels 176 Ole Miss
u56.5 -110 u13.5 -115 + N/A u13.5 -115 + N/A N/A u13.5 -110 + N/A N/A u57.5 -110  
LSU Tigers 175 LSU
-125 -115 + N/A -110 + N/A N/A -128 + N/A N/A +102  
Ole Miss Rebels 176 Ole Miss
+105 -115 + N/A -120 + N/A N/A -100 + N/A N/A -125  
LSU Tigers 175 LSU
+2.5 -110 +0.5 -170 + N/A -0.5 +114 + N/A N/A +1.5 -178 + N/A N/A +1.5 -108  
Ole Miss Rebels 176 Ole Miss
-2.5 -110 -0.5 +140 + N/A +0.5 -145 + N/A N/A -1.5 +132 + N/A N/A -1.5 -112  
LSU Tigers 175 LSU
o56.5 -110 o14.5 -110 + N/A o14.5 -115 + N/A N/A o14.5 +114 + N/A N/A o57.5 -110  
Ole Miss Rebels 176 Ole Miss
u56.5 -110 u14.5 -120 + N/A u14.5 -115 + N/A N/A u14.5 -142 + N/A N/A u57.5 -110  
LSU Tigers 175 LSU
-125 -115 + N/A -115 + N/A N/A -111 + N/A N/A +102  
Ole Miss Rebels 176 Ole Miss
+105 -115 + N/A -115 + N/A N/A -115 + N/A N/A -125  

The LSU Tigers will take on the Ole Miss Rebels in this week's college football action. Kickoff is set for 3:30 p.m. EDT at Vaught-Hemingway Stadium in Oxford, Miss. The game will be broadcast live on ABC. Here's everything you need to know about LSU vs. Ole Miss odds, the latest college football spreads, college football over/unders and more.

The Ole Miss opened as a -1.5 point favorite over LSU. The total is set at over/under 55.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 9/26/25

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LSU vs. Ole Miss Best Bet

Ole Miss is an offensive juggernaut, especially with Trinidad Chambliss under center. They have put up 40+ points and he has thrown for 300+ yards in each of his 2 games, while adding another 174 rushing yards and 2 TDs. On the other side, LSU's offense has struggled a bit, but I have faith in Garrett Nussmeier and that talented group of receivers to score on this Ole Miss defense that has shown leaks thus far.

Defensively, LSU's defense looks dominant, allowing just 10 or fewer points in every game, but if we look at the opponents, their vaunted defense looks a bit less impressive. Clemson's offense looks completely inept, LA Tech and SE Louisiana hardly count as offenses, and I'm not even sure Florida is legally a football team anymore. This is a massive step up in class for this LSU defense, and I don't think they'll be able to contain Ole Miss much better than Arkansas did. Lane Kiffin wants to push the tempo and light up the scoreboard, and I think he'll be able to do that on Saturday.

LSU vs. Ole Miss Best Bet: LSU Tigers @ Ole Miss Rebels o56.5 (-105)


PLACE THIS BET INSTANTLY AT bet365!

(Pick from Jourdan Case)

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What Time is the LSU vs. Ole Miss Game?

The Tigers will take on the Rebels at 3:30 PM ET on Saturday, September 27th.

Where is the LSU vs. Ole Miss Game Being Played?

This game is going to be played at Vaught-Hemingway Stadium in Oxford, Miss.

How Can I Watch The LSU vs. Ole Miss Game?

You can watch Georgia vs. Alabama on ABC.

Can LSU Beat Ole Miss?

Absolutely! LSU is actually a favorite, so the oddsmakers believe that LSU will win this game.

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 2 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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