Sign Up Subscribe
Featured Last Updated Sep 15 2026, 11:37 AM

Louisville vs. SMU Prediction: Louisville Creates Distance in ACC

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
14 minute read
Louisville vs. SMU Prediction: Louisville Creates Distance in ACC

Updated on 9/15/26

Polymarket
Deposit $10, Get a $50 Trading Bonus!
Bonus Code
INSIDER
Claim $50
18+ Only. Restrictions and eligibility requirements apply. Not available in all jurisdictions. Trading is risky. 100% loss can occur. See polymarket.com/tos for more information. The Polymarket US App serves as an independent software provider and affiliate of Polymarket US and Polymarket Clearing, the CFTC-regulated exchange and clearing organization.

The Louisville Cardinals will take on the SMU Mustangs in this week's college football action. Kickoff is set for 3:30p.m. EST at L&N Federal Credit Union Stadium in Louisville, KY. The game will be broadcast live on ESPN2. Here's everything you need to know about Louisville vs. SMU odds, the latest college football spreads, college football over/unders and more.

SMU @ LOU Odds

  • Full Game
  • 1H
  • 1Q
  • 4Q
  • 2Q
  • 3Q
  • Spread
  • Total
  • Moneyline
SMU Mustangs 141 SMU
+1.5 -110 +0.5 -120 + +0.5 -120 + +0.5 -120 + N/A +1.5 -138 + +0.5 -120 + +1.5 -140 + +1.5 -127 + +1.5 -112  
Louisville Cardinals 142 Louisville
-1.5 -110 -0.5 even + -0.5 even + -0.5 even + N/A -1.5 +112 + -0.5 -110 + -1.5 +105 + -1.5 +102 + -1.5 -108  
SMU Mustangs 141 SMU
o56.5 -115 o30.5 -120 + o30.5 -105 + o30.5 -105 + o30.5 -108 + o30.5 -104 + o30.5 -115 + o30.5 -125 + o30.5 -121 + o59.5 -112  
Louisville Cardinals 142 Louisville
u56.5 -105 u30.5 even + u30.5 -112 + u30.5 -115 + u30.5 -113 + u30.5 -118 + u30.5 -120 + u30.5 -105 + u30.5 -108 + u59.5 -108  
SMU Mustangs 141 SMU
-108 -105 + -108 + -102 + -107 + -108 + N/A N/A -107 + even  
Louisville Cardinals 142 Louisville
-112 -115 + -110 + -118 + -114 + -114 + N/A N/A -121 + -120  
SMU Mustangs 141 SMU
+1.5 -110 -0.5 +135 + -0.5 +120 + +0.5 -175 + N/A -1.5 +136 + +0.5 -145 + -0.5 +130 + +1.5 -175 + +1.5 -112  
Louisville Cardinals 142 Louisville
-1.5 -110 +0.5 -170 + +0.5 -160 + -0.5 +135 + N/A +1.5 -166 + -0.5 +110 + +0.5 -180 + -1.5 +130 + -1.5 -108  
SMU Mustangs 141 SMU
o56.5 -115 o13.5 -130 + o13.5 -110 + o13.5 -110 + N/A o13.5 -116 + o13.5 -125 + o13.5 -115 + o13.5 -125 + o59.5 -112  
Louisville Cardinals 142 Louisville
u56.5 -105 u13.5 even + u13.5 -115 + u13.5 -120 + N/A u13.5 -106 + u13.5 even + u13.5 -115 + u13.5 -104 + u59.5 -108  
SMU Mustangs 141 SMU
-108 -115 + -120 + -115 + N/A -112 + N/A N/A -112 + even  
Louisville Cardinals 142 Louisville
-112 -115 + -108 + -115 + N/A -104 + N/A N/A -117 + -120  
SMU Mustangs 141 SMU
+1.5 -110 +0.5 -155 + N/A N/A N/A +1.5 -158 + -0.5 +120 + N/A N/A +1.5 -112  
Louisville Cardinals 142 Louisville
-1.5 -110 -0.5 +115 + N/A N/A N/A -1.5 +130 + +0.5 -155 + N/A N/A -1.5 -108  
SMU Mustangs 141 SMU
o56.5 -115 o14 -125 + N/A N/A N/A o14.5 -110 + o14.5 -110 + N/A N/A o59.5 -112  
Louisville Cardinals 142 Louisville
u56.5 -105 u14 -115 + N/A N/A N/A u14.5 -110 + u14.5 -115 + N/A N/A u59.5 -108  
SMU Mustangs 141 SMU
-108 -115 + N/A N/A N/A -100 + N/A N/A N/A even  
Louisville Cardinals 142 Louisville
-112 -125 + N/A N/A N/A -116 + N/A N/A N/A -120  
SMU Mustangs 141 SMU
+1.5 -110 N/A N/A N/A N/A +1.5 -146 + +0.5 -135 + N/A N/A +1.5 -112  
Louisville Cardinals 142 Louisville
-1.5 -110 N/A N/A N/A N/A -1.5 +120 + -0.5 +105 + N/A N/A -1.5 -108  
SMU Mustangs 141 SMU
o56.5 -115 o16.5 -120 + N/A N/A N/A o16.5 -128 + o16.5 -130 + N/A N/A o59.5 -112  
Louisville Cardinals 142 Louisville
u56.5 -105 u16.5 -120 + N/A N/A N/A u16.5 +106 + u16.5 even + N/A N/A u59.5 -108  
SMU Mustangs 141 SMU
-108 -120 + N/A N/A N/A -100 + N/A N/A N/A even  
Louisville Cardinals 142 Louisville
-112 -120 + N/A N/A N/A -116 + N/A N/A N/A -120  
SMU Mustangs 141 SMU
+1.5 -110 N/A N/A N/A N/A +1.5 -150 + -0.5 +130 + N/A N/A +1.5 -112  
Louisville Cardinals 142 Louisville
-1.5 -110 N/A N/A N/A N/A -1.5 +124 + +0.5 -165 + N/A N/A -1.5 -108  
SMU Mustangs 141 SMU
o56.5 -115 o13.5 -125 + N/A N/A N/A o13.5 -116 + o13.5 -120 + N/A N/A o59.5 -112  
Louisville Cardinals 142 Louisville
u56.5 -105 u13.5 -115 + N/A N/A N/A u13.5 -106 + u13.5 -105 + N/A N/A u59.5 -108  
SMU Mustangs 141 SMU
-108 -115 + N/A N/A N/A +106 + N/A N/A N/A even  
Louisville Cardinals 142 Louisville
-112 -125 + N/A N/A N/A -136 + N/A N/A N/A -120  
SMU Mustangs 141 SMU
+1.5 -110 N/A N/A N/A N/A N/A N/A N/A N/A +1.5 -112  
Louisville Cardinals 142 Louisville
-1.5 -110 N/A N/A N/A N/A N/A N/A N/A N/A -1.5 -108  
SMU Mustangs 141 SMU
o56.5 -115 N/A N/A N/A N/A N/A o28.5 -115 + N/A N/A o59.5 -112  
Louisville Cardinals 142 Louisville
u56.5 -105 N/A N/A N/A N/A N/A u28.5 -115 + N/A N/A u59.5 -108  
SMU Mustangs 141 SMU
-108 N/A N/A N/A N/A N/A N/A N/A N/A even  
Louisville Cardinals 142 Louisville
-112 N/A N/A N/A N/A N/A N/A N/A N/A -120  

The Louisville Cardinals opened as a -1.5 point favorite over SMU. The total is set at over/under 59.5 total points scored by both teams combined.

Google Preferred Source

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the Polymarket promo code!

Updated on 9/15/26

bet365
Bet $10, Get $150 in Bonus Bets Win or Lose!
Bonus Code
VIBONUS
Click to Apply Code!
Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Must be 21+ and physically present in IL, or TN. Please gamble responsibly. New customers only. Claim via app. $10 min. Deposit required. Bonus Bets are non-withdrawable and expire 7 days after receipt. Bonus Bet wager excluded from returns. Time limits, min. Odds and T&Cs apply. This code is used for marketing and tracking purposes only. Void where prohibited.

Louisville vs. SMU Prediction

Louisville operates from a 50/50 run-pass split, establishing balance on offense. They've faced the 11th-toughest strength of schedule and competed in a shootout with Ole Miss in Week 1. That early adversity tested their mettle.

The efficiency metrics are strong. 0.17 EPA per run and 0.55 EPA per pass show Louisville is gaining value in each aspect of the offense. Lincoln Kienholz's 142.4 passer rating under pressure demonstrates composure when things break down. His 4.35% big-time throw rate indicates he has big-play capabilities.

The deciding factor is Kevin Jennings. SMU's quarterback has a 6.41% turnover-worthy play rate. That's significant. One turnover in a close game could cost SMU. Louisville's consistency and operational discipline give them the edge against a team that lives on variance.

bet louisville moneyline now

Louisville vs. SMU Prediction: Louisville Moneyline (-115)

(Pick from Dylan Wilkerson)

Looking for more college football predictions? Check out our free college football picks and our premium subscription for the best picks!

Featured News

Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
•