Cal Poly Mustangs Odds
| Date | Opp | Close | Result | ATS/OU |
| Aug 30, 2025 | @San Diego | -
/ | | 8:00 PM ET |
| Sep 6, 2025 | @Utah | -
/ | | 6:00 PM ET |
| Sep 13, 2025 | Western Oregon | -
/ | | 8:00 PM ET |
| Sep 20, 2025 | @Stephen F. Austin | -
/ | | 8:00 PM ET |
| Sep 27, 2025 | @Sacramento State | -
/ | | 12:00 PM ET |
| Oct 4, 2025 | UC Davis | -
/ | | 8:00 PM ET |
| Oct 11, 2025 | @Montana | -
/ | | 12:00 PM ET |
| Oct 25, 2025 | Montana State | -
/ | | 8:00 PM ET |
| Nov 1, 2025 | Portland State | -
/ | | 5:00 PM ET |
| Nov 8, 2025 | @Idaho State | -
/ | | 1:00 PM ET |
| Nov 15, 2025 | @Northern Arizona | -
/ | | 1:00 PM ET |
| Nov 22, 2025 | Eastern Washington | -
/ | | 7:00 PM ET |
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