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USC vs. Oregon: Prediction, Odds

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
USC vs. Oregon: Prediction, Odds

Image Credit: Ben Lonergan via Imagn Images

The USC Trojans will take on the Oregon Ducks in this week's NCAAF action. Kickoff is set for 3:30 p.m. EST at Autzen Stadium in Eugene, Ore. The game will be broadcast live on CBS. Here's everything you need to know about USC vs. Oregon odds, the latest NCAAF spreads, NCAAF over/unders and more.

The Oregon opened as a -9.5 point favorite over USC. The total is set at over/under 59.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 5/21/26

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USC vs. Oregon Best Bet

Completely disagree with the Oregon money here. Gonna buy this back above 10. USC was getting this same number at ND in a game where they still covered in despite turning the ball over 3 times. That’s with market inflation of Riley being bad outside the west coast as well.

However, Oregon’s pass rush is not elite by any means, being graded out in the bottom half of the Big Ten, and that’s how you beat Jayden Maiava (133.1 Passer Rating when kept clean compared to just a 42.8 when pressured). I don’t think Oregon will be able to exploit Maiava crumbling under pressure enough.

Had this spot circled as this is USC’s Super Bowl with two losses. Also for what it's worth, the lookahead at FanDuel just a week ago was sitting at Oregon -6.5.

I know that market isn’t as efficient but this line going up to 10.5 for basically no reason is just too much love to an Oregon team that has underwhelmed us in all three big games they’ve played.

USC vs.Oregon Best Bet: USC +10.5

(Pick from Anders)

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What Time is the USC vs. Oregon Game?

The Oregon Ducks will take on the USC Trojans at 3:30 PM ET.

Where is the USC vs. Oregon Game Being Played?

This game is going to be played at Autzen Stadium in Eugene, Ore.

How Can I Watch USC vs. Oregon?

You can watch USC vs. Oregon on CBS.

Can USC Beat Oregon?

Yes, read Anders' analysis above to see why USC is not only a threat to cover the spread but potentially pull off the big upset.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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