USC vs. Oregon: Prediction, Odds

USC vs. Oregon: Prediction, Odds

Image Credit: Ben Lonergan via Imagn Images

USC @ ORE Odds

The USC Trojans will take on the Oregon Ducks in this week's NCAAF action. Kickoff is set for 3:30 p.m. EST at Autzen Stadium in Eugene, Ore. The game will be broadcast live on CBS. Here's everything you need to know about USC vs. Oregon odds, the latest NCAAF spreads, NCAAF over/unders and more.

The Oregon opened as a -9.5 point favorite over USC. The total is set at over/under 59.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 9/14/26

bet365
Bet $10, Get $150 in Bonus Bets Win or Lose!
Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Must be 21+ and physically present in IL, or TN. Please gamble responsibly. New customers only. Claim via app. $10 min. Deposit required. Bonus Bets are non-withdrawable and expire 7 days after receipt. Bonus Bet wager excluded from returns. Time limits, min. Odds and T&Cs apply. This code is used for marketing and tracking purposes only. Void where prohibited.

USC vs. Oregon Best Bet

Completely disagree with the Oregon money here. Gonna buy this back above 10. USC was getting this same number at ND in a game where they still covered in despite turning the ball over 3 times. That’s with market inflation of Riley being bad outside the west coast as well.

However, Oregon’s pass rush is not elite by any means, being graded out in the bottom half of the Big Ten, and that’s how you beat Jayden Maiava (133.1 Passer Rating when kept clean compared to just a 42.8 when pressured). I don’t think Oregon will be able to exploit Maiava crumbling under pressure enough.

Had this spot circled as this is USC’s Super Bowl with two losses. Also for what it's worth, the lookahead at FanDuel just a week ago was sitting at Oregon -6.5.

I know that market isn’t as efficient but this line going up to 10.5 for basically no reason is just too much love to an Oregon team that has underwhelmed us in all three big games they’ve played.

USC vs.Oregon Best Bet: USC +10.5

(Pick from Anders)

Looking for more best bets? Check out our free college football picks and our premium subscription for the best picks!

What Time is the USC vs. Oregon Game?

The Oregon Ducks will take on the USC Trojans at 3:30 PM ET.

Where is the USC vs. Oregon Game Being Played?

This game is going to be played at Autzen Stadium in Eugene, Ore.

How Can I Watch USC vs. Oregon?

You can watch USC vs. Oregon on CBS.

Can USC Beat Oregon?

Yes, read Anders' analysis above to see why USC is not only a threat to cover the spread but potentially pull off the big upset.