College Football Week 5 Best Bets, College Football Picks

College Football Week 5 Best Bets, College Football Picks

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Week 5 of college football has a MASSIVE slate of games lined up. Here are my best bets for week 5 of college football!

Check out the latest college football odds, and the latest college football week 3 odds report.

Updated on 9/25/25

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Alabama Crimson Tide vs. Georgia Bulldogs Best Bet

BAMA @ UGA Odds

I like to think that this is going to be a contrarian pick. Georgia is coming off an overtime win against the Tennessee Volunteers, followed by a bye week. Alabama suffered an early week 1 loss to Tommy Castellanos and the Florida State Seminoles and have not looked back since. Ty Simpson has looked great since the loss to FSU, and even in the FSU loss he only had one turnover worth play. In that loss, he battled nearly a 15% drop rate from his receivers. They have since cleaned up the drops and have looked like a different team.

If we think back to the Georgia vs. Tennessee game, Georgia had no business winning. It took a missed field goal from Tennessee for Georgia to take the game to OT where they eventually won. Kalen DeBoer has his back against the wall, and this game may right all of his wrongs.

Alabama Crimson Tide vs. Georgia Bulldogs Best Bet: Alabama Crimson Tide +3 (-108)/Alabama Moneyline (+135)


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(Pick from Dylan Wilkerson)

TCU Horned Frogs vs. Arizona State Sun Devils Best Bet

TCU @ ASU Odds

We were able to get TCU -7 home last week against the SMU Mustangs thanks to their high-powered offense. I expect more of the same this week against the Arizona State Sun Devils. Josh Hoover has been extremely efficient in the air this season, averaging .35 expected points added per

pass. The Horned Frogs have also been incredibly efficient on 3rd and 4th down, converting on 66% of their tries.

The Sun Devils' defense will not have enough power to stop this offensive attack. ASU's rush defense is 117th in EPA/rush allowed and their pass defense is average at best. TCU will continue this offensive success in this Big 12 matchup.

TCU Horned Frogs vs. Arizona State Sun Devils Best Bet: TCU Horned Frogs +2.5 (-105)


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(Pick from Dylan Wilkerson)

Arkansas vs. Notre Dame Best Bet

ND @ ARK Odds

Arkansas has all of the makings of a live dog from now, until the end of the season. They have one of the most explosive and exciting offenses in college football. If Taylen Green was on a winning team, there would be serious Heisman talks surrounding him. Notre Dame's defense is not what it was a year ago. They have the 130th pass defense in terms of EPA/pass allowed, and they allow tons of success on early downs.

Arkansas' offense is powerful enough to keep this game interesting. They have the 5th most EPA/rush, 5th most early downs EPA/play, and the 8th highest success rate on third down.

Taylen Green and the Razorbacks give Notre Dame a run for their money in this matchup.

Arkansas vs. Notre Dame Best Bet: Arkansas Razorbacks +5.5 (-108)/Arkansas Moneyline (+164)


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(Pick from Dylan Wilkerson)

Louisville Cardinals vs. Pittsburgh Panthers Best Bet

LOU @ PITT Odds

Both of these teams play rather slow. Louisville averages 67 plays per game, while Pittsburgh is averaging 69 plays per game. Louisville's pass defense is stout, allowing -0.47 EPA/pass. Most of their success on defense comes on early downs, allowing -0.15 EPA/ play on early downs.

Pitt's opponents average 9.42 yards to go on third down this season, and they only allow a 36.2% conversion rate on 3rd and 4th down. These defenses will be on full display and I expect points to be scarce.

Louisville Cardinals vs. Pittsburgh Panthers Best Bet: Under 58.5


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(Pick from Dylan Wilkerson)

Washington Huskies vs. Ohio State Buckeyes Best Bet

OSU @ WASH Odds

This is going to be a great matchup. Although there is no number next to the Washington Huskies' logo, there is no doubt they are one of the more surprising teams this season. They are the best team in the country in terms of EPA/rush on offense. They are the #2 team in the country in terms of EPA/rush. They are extremely efficient in both early and late downs. They have the offensive line to deal with the Buckeyes' defensive front. They have all of the offensive weapons needed to hang with Ohio State.

I have serious doubts that Ohio State will be able to get anything going on the ground, and once you have to put the game in Sayin's hands, it is all over.

The new Big Ten also presents traveling challenges. Although the Buckeyes are coming off a bye, it is never easy to have to travel three time zones to play a football game.

Washington Huskies vs. Ohio State Buckeyes Best Bet: Washington Huskies +8.5 (-110)


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