Chargers vs. Bills Predictions: Bills Benefit From Rest
Dylan Wilkerson Sports Betting Expert
Updated on 9/23/26
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The Los Angeles Chargers will take on the Buffalo Bills in this week's NFL action. Kickoff is set for 1:00 p.m. EST at Highmark Stadium in Orchard Park, NY. The game will be broadcast live on FOX. Here's everything you need to know about Chargers vs. Bills odds, the latest college football spreads, college football over/unders and more.
LAC @ BUF Odds
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|
| Open |  › |  › |  › |  › |  › |  › |  › |  | ||
 477 Chargers | +2.5 -110 | +7 -105 | +7 -110 | +7 -105 | +7 -106 | +7.5 -120 | +7 -105 | +7 -107 | +7 -105 | |
 478 Bills | -2.5 -110 | -7 -115 | -7 -108 | -7 -115 | -7 -114 | -7.5 -102 | -7 -115 | -7 -115 | -7 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | o48.5 -110 | o50.5 -105 | o50 -110 | o50.5 -105 | o50.5 -105 | o50.5 -105 | o50 -110 | o50 -112 | o50.5 -105 | |
| 478 Bills | u48.5 -110 | u50.5 -115 | u50 -108 | u50.5 -115 | u50.5 -115 | u50.5 -115 | u50 -110 | u50 -108 | u50.5 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +120 | +280 | +280 | +270 | +265 | +300 | +275 | +275 | +270 | |
| 478 Bills | -142 | -360 | -350 | -340 | -335 | -375 | -350 | -385 | -340 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +2.5 -110 | +4.5 -115 | +4.5 -112 | +4.5 -120 | +4.5 -115 | +4.5 -110 | +5.5 -120 | +4.5 -124 | +7 -105 | |
| 478 Bills | -2.5 -110 | -4.5 -105 | -4.5 -105 | -4.5 even | -4.5 -105 | -4.5 -110 | -5.5 even | -4.5 even | -7 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | o48.5 -110 | o25.5 -110 | o25.5 -108 | o24.5 -110 | o24.5 -122 | o25.5 -110 | o24.5 -115 | o24.5 -113 | o50.5 -105 | |
| 478 Bills | u48.5 -110 | u25.5 -110 | u25.5 -110 | u24.5 -110 | u24.5 +102 | u25.5 -110 | u24.5 -115 | u24.5 -110 | u50.5 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +120 | +210 | +210 | +200 | +200 | +225 | +210 | +200 | +270 | |
| 478 Bills | -142 | -260 | -250 | -245 | -250 | -290 | -260 | -250 | -340 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +2.5 -110 | +2.5 even | +2.5 -108 | +2.5 -105 | N/A | +2.5 -110 | +2.5 even | +2.5 -109 | +7 -105 | |
| 478 Bills | -2.5 -110 | -2.5 -120 | -2.5 -120 | -2.5 -115 | N/A | -2.5 -110 | -2.5 -120 | -2.5 -114 | -7 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | o48.5 -110 | o9.5 -150 | o9.5 -140 | o9.5 -130 | N/A | o9.5 -134 | o9.5 -150 | o9.5 -139 | o50.5 -105 | |
| 478 Bills | u48.5 -110 | u9.5 +125 | u9.5 +110 | u9.5 +110 | N/A | u9.5 +110 | u9.5 +110 | u9.5 +114 | u50.5 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +120 | +180 | +170 | +180 | N/A | +172 | +170 | +170 | +270 | |
| 478 Bills | -142 | -220 | -220 | -218 | N/A | -215 | -230 | -215 | -340 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +2.5 -110 | +3.5 -115 | N/A | +3.5 -115 | N/A | +3.5 -110 | N/A | +3.5 -113 | +7 -105 | |
| 478 Bills | -2.5 -110 | -3.5 -105 | N/A | -3.5 -115 | N/A | -3.5 -110 | N/A | -3.5 -110 | -7 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | o48.5 -110 | o23.5 -125 | N/A | o24.5 even | N/A | o23.5 -125 | N/A | o24.5 -104 | o50.5 -105 | |
| 478 Bills | u48.5 -110 | u23.5 +105 | N/A | u24.5 -120 | N/A | u23.5 +105 | N/A | u24.5 -120 | u50.5 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +120 | +180 | N/A | +170 | N/A | +184 | N/A | +175 | +270 | |
| 478 Bills | -142 | -220 | N/A | -220 | N/A | -220 | N/A | -220 | -340 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +2.5 -110 | N/A | N/A | +2.5 -105 | N/A | +3.5 -126 | N/A | N/A | +7 -105 | |
| 478 Bills | -2.5 -110 | N/A | N/A | -2.5 -125 | N/A | -3.5 +104 | N/A | N/A | -7 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | o48.5 -110 | o15.5 -115 | N/A | o14.5 -110 | N/A | o15.5 -116 | N/A | N/A | o50.5 -105 | |
| 478 Bills | u48.5 -110 | u15.5 -115 | N/A | u14.5 -120 | N/A | u15.5 -106 | N/A | N/A | u50.5 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +120 | +170 | N/A | +145 | N/A | +180 | N/A | N/A | +270 | |
| 478 Bills | -142 | -220 | N/A | -188 | N/A | -225 | N/A | N/A | -340 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +2.5 -110 | N/A | N/A | +1.5 -120 | N/A | +1.5 -114 | N/A | N/A | +7 -105 | |
| 478 Bills | -2.5 -110 | N/A | N/A | -1.5 -110 | N/A | -1.5 -108 | N/A | N/A | -7 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | o48.5 -110 | o9.5 -135 | N/A | o10.5 +114 | N/A | o9.5 -140 | N/A | N/A | o50.5 -105 | |
| 478 Bills | u48.5 -110 | u9.5 +105 | N/A | u10.5 -145 | N/A | u9.5 +114 | N/A | N/A | u50.5 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +120 | +155 | N/A | +150 | N/A | +158 | N/A | N/A | +270 | |
| 478 Bills | -142 | -200 | N/A | -195 | N/A | -196 | N/A | N/A | -340 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +2.5 -110 | +1.5 -120 | N/A | +1.5 -110 | N/A | +1.5 -114 | N/A | N/A | +7 -105 | |
| 478 Bills | -2.5 -110 | -1.5 -110 | N/A | -1.5 -120 | N/A | -1.5 -108 | N/A | N/A | -7 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | o48.5 -110 | o13.5 -125 | N/A | o13.5 -135 | N/A | o13.5 -124 | N/A | N/A | o50.5 -105 | |
| 478 Bills | u48.5 -110 | u13.5 -105 | N/A | u13.5 +105 | N/A | u13.5 +102 | N/A | N/A | u50.5 -115 | |
| Open | › | › | › | › | › | › | › | | ||
| 477 Chargers | +120 | +140 | N/A | +140 | N/A | +142 | N/A | N/A | +270 | |
| 478 Bills | -142 | -180 | N/A | -180 | N/A | -176 | N/A | N/A | -340 | |
The Buffalo Bills opened as a -7 point favorite to Los Angeles. The total is set at over/under 50.5 total points scored by both teams combined.
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Updated on 9/23/26
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Chargers vs. Bills Prediction
This is a schedule play. The Bills last played on Thursday Night Football, and the Chargers played in a 4:25 PM ET game on Sunday against the Raiders. Again, I will take the team with the extra rest.
Chargers vs. Bills Prediction: Buffalo Bills -7 (-115)
(Pick from Dylan Wilkerson)
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