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Chargers vs. Bills Predictions: Bills Benefit From Rest

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
14 minute read
Chargers vs. Bills Predictions: Bills Benefit From Rest

Updated on 10/12/26

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The Los Angeles Chargers will take on the Buffalo Bills in this week's NFL action. Kickoff is set for 1:00 p.m. EST at Highmark Stadium in Orchard Park, NY. The game will be broadcast live on FOX. Here's everything you need to know about Chargers vs. Bills odds, the latest college football spreads, college football over/unders and more.

LAC @ BUF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
Los Angeles Chargers 477 Chargers
+2.5 -110 +4.5 -105 +5.5 -110 +4.5 -110 +4.5 -105 +4.5 -110 +5.5 -110 +4.5 -113 +7 -108  
Buffalo Bills 478 Bills
-2.5 -110 -4.5 -115 -5.5 -108 -4.5 -110 -4.5 -115 -4.5 -110 -5.5 -110 -4.5 -110 -7 -112  
Final
Los Angeles Chargers 477 Chargers
o48.5 -110 o24.5 -115 o25.5 -115 o25.5 -112 o24.5 -145 o25.5 -110 o26.5 -110 o25.5 -110 o50.5 -105  
Buffalo Bills 478 Bills
u48.5 -110 u24.5 -105 u25.5 -105 u25.5 -108 u24.5 +122 u25.5 -110 u26.5 -120 u25.5 -113 u50.5 -115  
Final
Los Angeles Chargers 477 Chargers
+120 +235 +220 +210 +220 +225 +220 +205 +260  
Buffalo Bills 478 Bills
-142 -290 -275 -258 -280 -290 -275 -265 -325  
Final
Los Angeles Chargers 477 Chargers
+2.5 -110 +2.5 even +2.5 -105 +2.5 even N/A +2.5 -110 +2.5 even +2.5 -112 +7 -108  
Buffalo Bills 478 Bills
-2.5 -110 -2.5 -120 -2.5 -120 -2.5 -120 N/A -2.5 -110 -2.5 -120 -2.5 -112 -7 -112  
Final
Los Angeles Chargers 477 Chargers
o48.5 -110 o9.5 -130 o9.5 -150 o9.5 -130 N/A o9.5 -136 o9.5 -140 o9.5 -136 o50.5 -105  
Buffalo Bills 478 Bills
u48.5 -110 u9.5 +110 u9.5 +115 u9.5 +110 N/A u9.5 +112 u9.5 +105 u9.5 +110 u50.5 -115  
Final
Los Angeles Chargers 477 Chargers
+120 +175 +170 +185 N/A +172 +170 +170 +260  
Buffalo Bills 478 Bills
-142 -210 -225 -225 N/A -215 -230 -215 -325  
Final
Los Angeles Chargers 477 Chargers
+2.5 -110 +3.5 -110 N/A +3.5 -120 N/A +3.5 -110 +3.5 -120 +3.5 -115 +7 -108  
Buffalo Bills 478 Bills
-2.5 -110 -3.5 -110 N/A -3.5 -110 N/A -3.5 -110 -3.5 even -3.5 -108 -7 -112  
Final
Los Angeles Chargers 477 Chargers
o48.5 -110 o24.5 even N/A o24.5 +105 N/A o24.5 +105 o24.5 -105 o24.5 -105 o50.5 -105  
Buffalo Bills 478 Bills
u48.5 -110 u24.5 -120 N/A u24.5 -125 N/A u24.5 -125 u24.5 -125 u24.5 -120 u50.5 -115  
Final
Los Angeles Chargers 477 Chargers
+120 +180 N/A +160 N/A +182 +165 +170 +260  
Buffalo Bills 478 Bills
-142 -220 N/A -210 N/A -220 -200 -220 -325  
Final
Los Angeles Chargers 477 Chargers
+2.5 -110 N/A N/A +2.5 even N/A +3.5 -126 +3.5 -125 N/A +7 -108  
Buffalo Bills 478 Bills
-2.5 -110 N/A N/A -2.5 -130 N/A -3.5 +102 -3.5 +105 N/A -7 -112  
Final
Los Angeles Chargers 477 Chargers
o48.5 -110 o15.5 -115 N/A o15.5 -115 N/A o15.5 -112 o13.5 -170 N/A o50.5 -105  
Buffalo Bills 478 Bills
u48.5 -110 u15.5 -115 N/A u15.5 -115 N/A u15.5 -108 u13.5 +125 N/A u50.5 -115  
Final
Los Angeles Chargers 477 Chargers
+120 +160 N/A +165 N/A +184 +170 N/A +260  
Buffalo Bills 478 Bills
-142 -210 N/A -215 N/A -230 -230 N/A -325  
Final
Los Angeles Chargers 477 Chargers
+2.5 -110 N/A N/A +0.5 -115 N/A +1.5 -116 +0.5 -110 N/A +7 -108  
Buffalo Bills 478 Bills
-2.5 -110 N/A N/A -0.5 -115 N/A -1.5 -106 -0.5 -110 N/A -7 -112  
Final
Los Angeles Chargers 477 Chargers
o48.5 -110 o9.5 -155 N/A o9.5 -154 N/A o9.5 -138 o9.5 -155 N/A o50.5 -105  
Buffalo Bills 478 Bills
u48.5 -110 u9.5 +122 N/A u9.5 +120 N/A u9.5 +114 u9.5 +115 N/A u50.5 -115  
Final
Los Angeles Chargers 477 Chargers
+120 +140 N/A +135 N/A +154 +145 N/A +260  
Buffalo Bills 478 Bills
-142 -180 N/A -175 N/A -192 -190 N/A -325  
Final
Los Angeles Chargers 477 Chargers
+2.5 -110 +1.5 -110 N/A +1.5 -115 N/A +1.5 -116 +0.5 -105 N/A +7 -108  
Buffalo Bills 478 Bills
-2.5 -110 -1.5 -120 N/A -1.5 -115 N/A -1.5 -106 -0.5 -115 N/A -7 -112  
Final
Los Angeles Chargers 477 Chargers
o48.5 -110 o13.5 -125 N/A o13.5 -130 N/A o13.5 -122 o13.5 -115 N/A o50.5 -105  
Buffalo Bills 478 Bills
u48.5 -110 u13.5 -105 N/A u13.5 even N/A u13.5 -100 u13.5 -115 N/A u50.5 -115  
Final
Los Angeles Chargers 477 Chargers
+120 +140 N/A +135 N/A +142 +120 N/A +260  
Buffalo Bills 478 Bills
-142 -180 N/A -175 N/A -176 -160 N/A -325  

The Buffalo Bills opened as a -7 point favorite to Los Angeles. The total is set at over/under 50.5 total points scored by both teams combined.

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Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the Polymarket promo code!

Updated on 10/12/26

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Chargers vs. Bills Prediction

This is a schedule play. The Bills last played on Thursday Night Football, and the Chargers played in a 4:25 PM ET game on Sunday against the Raiders. Again, I will take the team with the extra rest.

bet the Bills spread now

Chargers vs. Bills Prediction: Buffalo Bills -7 (-115)

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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