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Featured Last Updated Nov 1 2026, 6:08 PM

2026 College Football Odds Week 10: Lines, Spreads, Betting Trends on Biggest Games

Patrick Everson
Patrick Everson Sports Betting Expert
12 minute read
2026 College Football Odds Week 10: Lines, Spreads, Betting Trends on Biggest Games

College Football Week 10 Odds include the Miami vs. Notre Dame showdown that people have been waiting for all season.

Georgia vs. Ole Miss is another huge highlight in Week 10 college football odds. So too is the Holy War of BYU vs. Utah, with big CFP ramifications for the Big 12.

Here’s everything you need to know about 2026 college football odds Week 10: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on college football Week 10 odds and action.

Prediction markets are in the mix, as well, so check out our Kalshi referral code and get in on the action today. Also, check back regularly for updates and use our bet365 bonus code to get the most out of your action.

Updated on 11/1/26

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2026 College Football Odds for Week 9

BYU vs. Utah Odds

  • Opening point spread: Utah -6.5
  • Opening moneyline: Utah TBA/BYU TBA
  • Opening total: Over/Under 46 points scored
  • Time: Noon ET Saturday (ABC)

OPENING ODDS UPDATE: No. 3 Utah (8-0 SU/7-1 ATS) did not mess around in Week 9, as it tuned up for its archrival. The Utes put up 42 first-half points and coasted to a 49-25 road victory laying 7.5 points vs. Cincinnati.

No. 7 BYU (7-1 SU/6-2 ATS) let all of a 17-3 halftime lead slip away in the third quarter, going to the fourth quarter tied at 17 vs. Arizona State. But the Cougars still got a 27-20 victory, while falling well short of cashing as 17.5-point home favorites.

Circa Sports' college football opening numbers are well-respected and often draw early sharp play. Circa opened Utah -6.5 in college football odds Week 10 and went to -6 within about 30 minutes Sunday afternoon.

The total opened at 46, and after about 45 minutes, the number went straight to 47.5.

Alabama vs. LSU Odds

  • Opening point spread: LSU -5
  • Opening moneyline: LSU TBA/Alabama TBA
  • Opening total: Over/Under 53 points scored
  • Time: 3:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: Alabama (6-2 SU/4-4 ATS) is coming off a bye week, after halting its first two-game regular-season losing streak since 2007. In Week 8, the Crimson Tide topped Texas A&M 31-20, but didn't cash as 13.5-point home favorites.

No. 8 Alabama is in an 0-3 ATS rut, after covering in four of its first five games.

No. 15 LSU (6-2 SU/4-4 ATS) also had a bye in Week 9. After an overtime loss at Kentucky, the Tigers rebounded with blowout wins over Mississippi State and at Auburn. In Week 9, LSU built a 31-10 halftime lead and coasted past Auburn 38-17 giving 7 points.

On Sunday afternoon, Circa Sports opened LSU as a 5-point home favorite in college football Week 10 odds Sunday afternoon. And the first move came just minutes later, to Tigers -5.5.

The total opened at 53 and within a few minutes inched to 53.5.

Oregon vs. Ohio State Odds

  • Opening point spread: Ohio State -8
  • Opening moneyline: Ohio State TBA/Oregon TBA
  • Opening total: Over/Under 49 points scored
  • Time: 3:30 p.m. ET Saturday (CBS)

OPENING ODDS UPDATE: Ohio State (6-2 SU/5-3 ATS) is in trouble without starting QB Julian Sayin (arm/shoulder). In Week 9 at USC, the first game Sayin missed, the Buckeyes were 6.5-point road favorites and tumbled outright 30-18.

That halted Ohio State's five-game SU win streak, which began after a 24-23 loss at Texas. The Buckeyes also fell from No. 2 to No. 11 in the AP poll.

Oregon (5-3 SU/3-5 ATS) was a perceived top-10 team and CFP contender preseason. It's been a bumpy ride since, compounded by losing QB Dante Moore for the season after a Week 4 concussion.

But in Week 9, the Ducks topped Northwestern 34-26 as 4-point home favorites. Oregon ended an 0-3 ATS slide with the win and cover.

Circa Sports opened Oregon-Ohio State at Buckeyes -8 Sunday afternoon, and 30 minutes later, Ohio State went straight to -7. The total was also on the move within 30 minutes or, opening at 49 and going straight to 47.5.

Kentucky vs. Tennessee Odds

  • Opening point spread: Tennessee -6.5
  • Opening moneyline: Tennessee TBA/Kentucky TBA
  • Opening total: Over/Under 51.5 points scored
  • Time: 6:15 p.m. ET Saturday (ESPN)

OPENING ODDS UPDATE: No. 8 Kentucky is one of this season's surprise stories, sitting at 7-1 SU and ATS and coming off a bye. In Week 8, the Wildcats dispatched Vanderbilt 34-17 as 10.5-point road favorites.

Kentucky got wiped out vs. Alabama in Week 2, 45-17 at home. But the Wildcats have a quartet of underdog outright wins this season: On the road vs. Texas A&M, South Carolina and Oklahoma, and at home vs. LSU.

No. 16 Tennessee (6-2 SU/4-4 ATS), also off a bye, is aiming not to be the fifth favorite slain by Kentucky. The Vols are coming off a 27-24 loss at South Carolina as 2.5-point underdogs.

Kentucky has the better record and ranking. But Circa Sports opened Tennessee as nearly a touchdown favorite, at Vols -6.5 Sunday afternoon. That number then bounced around a bit, dropping straight to -5.5 with five minutes, then settling at -6 after 30 minutes or so.

Miami vs. Notre Dame Odds

  • Opening point spread: Notre Dame -5
  • Opening moneyline: Notre Dame TBA/Miami TBA
  • Opening total: Over/Under 58 points scored
  • Time: 7:30 p.m. ET Saturday (NBC)

OPENING ODDS UPDATE: Miami (8-0 SU/5-3 ATS) got all it could handle as a 13.5-point favorite at North Carolina in Week 9. It was back-and-forth throughout, and the Hurricanes held on for a 38-35 victory.

Subsequently, Miami remained No. 1 in the AP poll for a third straight week.

No. 4 Notre Dame (7-1 SU/4-4 ATS) got more than expected against Navy in Week 9, trailing 13-7 late in the first half. But the Fighting Irish did the rest of the scoring in a 35-13 win, though they fell well short of covering as 31-point neutral-site favorites.

It was a bounce-back win for No. 4 Notre Dame, which had a Week 8 bye after losing at BYU 28-24 in Week 7.

Notre Dame opened as a 5-point home favorite vs. Miami in Circa Sports' college football Week 10 odds Sunday afternoon. Within four minutes, the first move was toward the 'Canes, with the Irish dipping to -4.5.

Georgia vs. Ole Miss Odds

  • Opening point spread: Georgia -3
  • Opening moneyline: Georgia TBA/Ole Miss TBA
  • Opening total: Over/Under 56.5 points scored
  • Time: 7:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: No. 2 Georgia (7-1 SU/6-2 ATS) rebounded just fine from its stunning 27-24 Week 7 home loss to Auburn. Coming off a bye, the Bulldogs put Florida in a 24-0 hole and breezed to a 27-8 victory as 11.5-point neutral-site favorites in Atlanta.

No. 12 Ole Miss (6-2 SU/4-4 ATS) took a bit to get going in Week 9, but ultimately rolled over Auburn. The Rebels led 14-9 at halftime, then scored 31 of the final 37 points in a 45-15 blowout laying 10.5 points at home.

On Sunday afternoon, Circa Sports opened Georgia-Ole Miss at Bulldogs -3 on the road in Week 10 college football odds. Forty minutes later, Georgia advanced to -3.5.

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Patrick Everson

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson
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