NFL Odds Week 1: Lines, Spreads, Betting Trends For All 16 Games

Patrick Everson Sports Betting Expert

16 minute read

2025 NFL Odds Week 1

NFL odds for Week 1 bring an end to our long national nightmare: Nearly eight months without a meaningful pro football game.

The league certainly made things spicy, with a few marquee matchups in odds for NFL Week 1. Arguably the best of the bunch: Baltimore Ravens vs. Buffalo Bills on Sunday night.

Here’s everything you need to know about the NFL odds Week 1 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on NFL Week 1 odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Bill Streicher/Imagn Images)

NFL Odds for Every Game of NFL Week 1

Dallas Cowboys vs. Philadelphia Eagles Odds

• Opening point spread: Eagles -7
• Opening moneyline: Eagles -330/Cowboys +270
• Opening total: Over/Under 47.5 points scored
• Time: 8:20 p.m. ET Thursday, Sept. 4 (NBC)

UPDATE 10 P.M. ET SUNDAY: Defending Super Bowl champion Philadelphia went 18-3 SU and a stout 14-7 ATS last season. The Eagles were 4-0 SU/3-1 ATS in the playoffs, capped by their impressive 40-22 rout of Kansas City as 1.5-point underdogs.

Dallas (7-10 SU and ATS) missed the playoffs last season, but managed to go 5-2 ATS in its last seven games. In the regular-season finale, the Cowboys were 7-point home underdogs vs. Washington and nearly got the upset, losing 23-19 on a final-seconds touchdown.

One potentially notable issue for Dallas: With 11 days until the season opener, star defensive end Micah Parsons still doesn't have a new contract.

The SuperBook first posted NFL Week 1 odds on May 13, installing the Eagles as 7-point home favorites. That line stuck most of the summer, dipping to -6.5 for literally two hours on Aug. 11, before returning to -7.

"There are more tickets and money on Cowboys spread. Not much on the moneyline yet, but I anticipate the Eagles being involved in a million different parlays and teasers," SuperBook risk manager Casey Degnon said tonight. "It feels like we'll be rooting for Dallas to spoil the Eagles' banner night."

The total opened at 47.5 and went to 47/46.5 July 9. On Aug. 11, it bottomed out at 45.5 for a couple hours, then returned to 46.5.

"Some action on the Under has dropped us a point from the opener," Degnon said.

Kansas City Chiefs vs. Los Angeles Chargers Odds

• Opening point spread: Chiefs -2.5
• Opening moneyline: Chiefs -140/Chargers +120
• Opening total: Over/Under 44.5 points scored
• Time: 8 p.m. ET Friday, Sept. 5 (YouTube)

UPDATE 10 P.M. ET SUNDAY: Kansas City (17-3 SU/9-11 ATS) has won five of the past six AFC titles, along with three Super Bowls. But the last time we saw the Chiefs, they were getting thumped by Philadelphia 40-22 in Super Bowl 59.

K.C. closed as 1.5-point chalk in that game and was never in it, trailing 34-0 at one point late in the third quarter.

Los Angeles (11-7 SU/12-6 ATS) had a relatively successful first season under coach Jim Harbaugh. The Chargers landed a Wild Card berth, but lost to Houston 32-12 as 2.5-point road favorites.

Chiefs-Chargers is a neutral-site matchup, taking place in Sao Paulo, Brazil. Kansas City opened -2.5 in The SuperBook's Week 1 NFL odds and didn't budge for nearly three months. On Aug. 5, the Chiefs went to -3, and the line adjusted to -3 (-120) on Aug. 7.

"Action here is pretty split moneywise, but more than double the tickets on the Chiefs," SuperBook risk manager Casey Degnon said of spread play. "Moneyline, on straight bets and parlays, is all Chiefs right now, as well.

"I would be surprised if we don't need the Chargers when they kickoff.

The total opened at 44.5, peaked at 46.5 in mid-June and is now 45.5.

"Tickets on the total are 50/50, but there's more money on the Over, and I think the public will continue to bet that way," Degnon said.

Cincinnati Bengals vs. Cleveland Browns Odds

• Opening point spread: Bengals -4.5
• Opening moneyline: Bengals -250/Browns +210
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday, Sept. 7 (FOX)

UPDATE 10 P.M. ET SUNDAY: Cleveland (3-13 SU/5-12 ATS) is coming off a dismal campaign and isn't exactly stable at quarterback. Joe Flacco was named the Week 1 starter, in a locker room that includes Kenny Pickett and a pair of rookies: Dillon Gabriel and Shedeur Sanders.

Then there's Deshaun Watson, who tore his Achilles in action last October, then re-tore it January during rehab. He's currently on the physically unable to perform list.

The Browns finished last season on an 0-6 SU and ATS purge, with all six losses by nine points or more.

Cincinnati (9-8 SU/10-7 ATS) made a late playoff push last season, winning their final five games. But it was too little, too late, to reach the postseason.

That's two straight 9-8 campaigns, with Cincy missing the playoffs both years. In 2022-23, the Bengals lost to Kansas City in the AFC Championship Game, and in 2021-22, they lost to the L.A. Rams in the Super Bowl.

The SuperBook opened Cincinnati -4.5 in its NFL odds Week 1 market, and literally within minutes on May 14, the number jumped to -5.5. It stuck at Bengals -5.5 all summer, then today bumped to -6.

The total opened at 46.5, bottomed out at 45 June 19 and in the past week rebounded to 45.5/46.5.

Pittsburgh Steelers vs. New York Jets Odds

• Opening point spread: Steelers -3
• Opening moneyline: Steelers -155/Jets +135
• Opening total: Over/Under 39 points scored
• Time: 1 p.m. ET Sunday, Sept. 7 (CBS)

UPDATE 10 P.M. ET SUNDAY: Pittsburgh (10-8 SU/11-7 ATS) got an AFC Wild Card bid last season. But that's as far as the Steelers could stretch it, losing at Baltimore 28-14 as 9-point underdogs.

This season, Pittsburgh trots out Aaron Rodgers in what he said will likely be his final campaign.

Speaking of Rodgers, New York (5-12 SU/6-11 ATS) moves on from the veteran QB, though it's not necessarily an upgrade this season. Justin Fields, playing on his third team in three seasons, is No. 1 on the Jets' depth chart.

New York's 2024-25 season got blown up by losing streaks of five and four games.

The SuperBook opened the Steelers -3 in Week 1 NFL odds. The line has been stuck at Pittsburgh -3 (even) since late May.

"Currently more tickets on the Steelers, but more money on the Jets, on straight bets and parlays," SuperBook risk manager Casey Degnon said of early point-spread play. "I think we will continue to see split action on this game. I'm not sure we will know the need until right before kickoff.

"Nothing to the moneyline right now, just some smaller tickets on the Jets at plus money. Same with the total. Not a real decision, but some sprinkles on the Under."

The total opened at 39, nudged to 38.5 July 24, then this morning dipped to 38.

New York Giants vs. Washington Commanders Odds

• Opening point spread: Commanders -7
• Opening moneyline: Commanders -380/Giants +320
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday, Sept. 7 (FOX)

UPDATE 10 P.M. ET SUNDAY: Washington (14-6 SU/12-7-1 ATS) made a surprising run to the NFC Championship Game, behind Rookie of the Year QB Jayden Daniels. The Commanders shocked No. 1 seed Detroit in the Divisional Round, winning 45-31 as 8.5-point 'dogs.

But Daniels & Co. had no answer for Philly a week later, getting blown out 55-23 as 6-point road pups.

New York (3-14 SU/5-12 ATS) tied for the worst record in the league last season. From Weeks 6-16, the Giants lost 10 consecutive games. This season brings a new quarterback, with Russell Wilson moving on from Pittsburgh to the Big Apple.

Washington opened as 7-point chalk in The SuperBook's NFL Week 1 odds. The line spent most of the summer at various iterations of Commanders -6.5, then dipped to -6 on Aug. 20.

The total opened at 46.5, bottomed out at 45.5 and peaked at 47.5, all by early June. This morning, the total moved from 45.5 to 46.

Tampa Bay Buccaneers vs. Atlanta Falcons Odds

• Opening point spread: Pick
• Opening moneyline: Buccaneers -125/Falcons +105
• Opening total: Over/Under 49.5 points scored
• Time: 1 p.m. ET Sunday, Sept. 7 (FOX)

UPDATE 10 P.M. ET SUNDAY: Tampa Bay (10-8 SU and ATS) won the NFC South last season to get a home game on Wild Card Weekend. But the Bucs didn't advance, losing 23-20 as 3-point favorites vs. Washington.

Atlanta (8-9 SU/7-10 ATS) had a shot at the division title late in the season. But the Falcons dropped their final two contests, both in overtime. The season ended with a 44-38 OT loss laying 7.5 points at home vs. Carolina, in a game that had big Circa Survivor implications.

This game opened at pick in The SuperBook's NFL odds Week 1 market. By May 23, the Bucs were up to 2.5-point road favorites, but on July 9, the line backed up to -1.5/-1. Tampa returned to -1.5 Aug. 4 and this morning went to -2.

The total opened at 49.5 and slowly made its way to down to 47.5, a low point reached this morning.

Las Vegas Raiders vs. New England Patriots Odds

• Opening point spread: Patriots -3.5
• Opening moneyline: Patriots -160/Raiders +140
• Opening total: Over/Under 44 points scored
• Time: 1 p.m. ET Sunday, Sept. 7 (CBS)

UPDATE 10 P.M. ET SUNDAY: Las Vegas (4-13 SU/7-10 ATS) had yet another disappointing season. The Raiders lost 10 in a row from Weeks 5-15, leading to the firing of coach Antonio Pierce.

Pete Carroll is the new coach, and he tapped his Seattle roots by trading to acquire quarterback Geno Smith, who is No. 1 on the depth chart.

New England (4-13 SU/7-9-1 ATS) sent coach Jerod Mayo packing after a poor 2024 campaign. The Patriots endured two six-game losing streaks last season. In Mayo's place, another former Patriots star stepped in, with Mike Vrabel taking over as coach.

Back on May 14, The SuperBook opened New England -3.5. Within minutes, the Pats dipped to -3, and they stuck at that number all summer. The Patriots have been at -3 (even) since June 18.

The total opened at 44, slid to 42.5 within three weeks and hasn't moved since June 2.

Miami Dolphins vs. Indianapolis Colts Odds

• Opening point spread: Pick
• Opening moneyline: Dolphins -110/Colts -110
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday, Sept. 7 (CBS)

UPDATE 10 P.M. ET SUNDAY: Miami (8-9 SU and ATS) needs to find a way to keep Tua Tagovailoa in the lineup. Last year, Tagovailoa missed six games: four after a Week 2 concussion and the final two due to a hip injury. Miami was 2-4 SU without its No. 1 quarterback.

Indianapolis (8-9 SU/9-8 ATS) drafted QB Anthony Richardson No. 4 overall in 2023, in hopes he'd be the long-term starting quarterback. Two seasons later, it was announced last week that offseason acquisition Daniel Jones will be the Week 1 starter, with Richardson the backup.

Dolphins vs. Colts opened as a pick 'em at The SuperBook, and Miami spent much of the summer as 1-point chalk. On Aug. 18, the line jumped the fence to Indy -1.5, then briefly went to Colts -2 Aug. 19, before reverting back to -1.5.

The total nudged from 46.5 to 47 back on May 23, and it hasn't budged since.

Carolina Panthers vs. Jacksonville Jaguars Odds

• Opening point spread: Jaguars -3
• Opening moneyline: Jaguars -150/Panthers +130
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday, Sept. 7 (FOX)

UPDATE 10 P.M. ET SUNDAY: Much like Miami, Jacksonville (4-13 SU/10-7 ATS) really needs to keep its quarterback upright. Trevor Lawrence played just 10 of 17 games last season, including missing the final five after a concussion.

Carolina (5-12 SU/8-9 ATS) is coming off another subpar season, but at least finished on an upward swing. The Panthers won two of their last three, including a 44-38 overtime victory as 7.5-point underdogs at Atlanta in Week 18.

Jacksonville opened -3 and spent much of the summer at -2.5 (-120) in The SuperBook's NFL odds Week 1 market. The Jags went to -3 (even) on Aug. 15 and -3 flat this morning.

The total hasn't moved off 46.5 all summer.

Arizona Cardinals vs. New Orleans Saints Odds

• Opening point spread: Cardinals -4.5
• Opening moneyline: Cardinals -220/Saints +190
• Opening total: Over/Under 43.5 points scored
• Time: 1 p.m. ET Sunday, Sept. 7 (CBS)

UPDATE 10 P.M. ET SUNDAY: New Orleans (5-12 SU/6-11 ATS) looks as if it'll have a quarterback problem this season. Derek Carr surprisingly retired in the offseason. Now, Spencer Rattler is No. 1 on the depth chart, followed by second-round draft pick Tyler Shough.

Arizona (8-9 SU/11-6 ATS) was actually one of the better spread-covering outfits last season. QB Kyler Murray played in all 17 games, following an injury-plagued three-season stretch in which he played 14, 11 and eight games.

With the Saints' dubious QB situation, The SuperBook opened the Cardinals -4.5 back on May 14. Arizona went to -5 May 23 and -6 May 25, with no movement since then in the NFL Week 1 odds market.

The total opened at 43.5, quickly went to 42.5 and hasn't moved in the three-plus months since.

Tennessee Titans vs. Denver Broncos Odds

• Opening point spread: Broncos -7.5
• Opening moneyline: Broncos -380/Titans +320
• Opening total: Over/Under 43.5 points scored
• Time: 4:05 p.m. ET Sunday, Sept. 7 (FOX)

UPDATE 10 P.M. ET SUNDAY: Denver went 10-7 SU and a solid 12-5 ATS – second-best in the NFL – in the 2024-25 regular season. That earned the Broncos an AFC Wild Card bid, but they unfortunately got sent to Buffalo for that game. Denver got thumped 31-7 catching 7.5 points.

Tennessee tied for the league's worst SU record last season, at 3-14, and was the worst ATS team, at 2-15. The Titans finished with an 0-6 SU and ATS nosedive.

Tennessee quarterback Will Levis underwent offseason shoulder surgery and is currently on injured reserve. So rookie Cam Ward, the No. 1 overall pick, is No. 1 on the Titans' depth chart.

Correspondingly, Denver is 7.5-point chalk in The SuperBook's Week 1 NFL odds. That number hasn't moved since opening on May 14.

The SuperBook's total did move in the early going, from 43.5 to 42.5/42, but it's been stable at 42 since May 19.

San Francisco 49ers vs. Seattle Seahawks Odds

• Opening point spread: 49ers -1
• Opening moneyline: 49ers -125/Seahawks +105
• Opening total: Over/Under 46 points scored
• Time: 4:05 p.m. ET Sunday, Sept. 7 (FOX)

UPDATE 10 P.M. ET SUNDAY: San Francisco (6-11 SU/5-12 ATS) has been a perennial NFC and Super Bowl contender. But injuries killed the Niners last season. Most notably, stud running back Christian McCaffrey missed 13 games, and wideout Brandon Aiyuk tore an ACL in Week 7.

McCaffrey is now healthy, but Aiyuk is expected to miss the first five games, at least. Further, star wideout Deebo Samuel was traded to Washington in the offseason.

Seattle (10-7 SU/6-10-1 ATS) had a respectable 2024-25 campaign. The Seahawks actually tied the L.A. Rams atop the NFC West, but lost the tiebreaker and failed to make the playoffs.

Seattle will usher in a new quarterback this season. The Seahawks signed Sam Darnold, as Geno Smith moved on to the Raiders. Darnold is coming off his easily his best season, guiding Minnesota to a 14-3 SU/11-4-1 ATS mark and a Wild Card appearance.

San Francisco opened -1 and spent a chunk of the summer at -1.5 in The SuperBook's NFL odds for Week 1. On July 29, the 49ers went to -2/-2.5, and there's been no movement since.

The total toggled between 46/45.5 a couple times early on, and it's been stable at 45 since June 19.

Detroit Lions vs. Green Bay Packers Odds

• Opening point spread: Lions -1
• Opening moneyline: Packers -120/Lions even
• Opening total: Over/Under 49.5 points scored
• Time: 4:25 p.m. ET Sunday, Sept. 7 (CBS)

UPDATE 10 P.M. ET SUNDAY: Last season, Detroit (15-3 SU/12-5-1 ATS) earned the NFC's No. 1 seed, a bye and home-field advantage. Then the Lions threw it away, getting trashed by Washington 55-23 as 8.5 point favorites in the Divisional Round.

Still, Detroit has been among the best teams in the league for 2.5 seasons now, particularly at the betting window. The Lions are 37-11 SU/35-12-1 ATS in their last 48 games.

Green Bay (11-6 SU/9-8 ATS) also had a solid 2024-25 campaign, earning an NFC Wild Card bid. But the Packers couldn't keep it going in the playoffs, losing at Philadelphia 22-10 as 5.5-point underdogs.

On May 14, The SuperBook opened Detroit -1 in 2025 NFL Week 1 odds. Within a couple days, the line moved to pick, then to Green Bay -1. The Packers advanced to -2 June 2 and -2.5 June 25, then returned to -2 July 29.

"Ticket count is 2/1 in favor of the Lions, but those are mostly smaller tickets. We have more money on the Packers and actually need the Lions right now," SuperBook risk manager Casey Degnon said. "Another game where I think the action will be pretty split.

"There are some smaller bets on the Lions moneyline, but not enough money to really effect the decision."

The total hasn't budged off 49.5 all summer, despite what Degnon termed "one-way traffic on the Over."

Houston Texans vs. Los Angeles Rams Odds

• Opening point spread: Rams -3
• Opening moneyline: Rams -155/Texans +135
• Opening total: Over/Under 46.5 points scored
• Time: 4:25 p.m. ET Sunday, Sept. 7 (CBS)

UPDATE 10 P.M. ET SUNDAY: Los Angeles (11-8 SU and ATS) won the NFC West and nearly got to the NFC Championship Game. The Rams rolled over Minnesota 27-9 as 2.5-point neutral-site underdogs on Wild Card Weekend.

Then L.A. gave eventual Super Bowl champ Philadelphia all it could handle, but lost 28-22 getting 7 points on the road.

Similarly, Houston (11-7 SU/9-10 ATS) won the AFC South, got a Wild Card victory over the L.A. Chargers, then bowed out in the Divisional Round. The Texans were 9.5-point road 'dogs vs. Kansas City and lost 23-14.

Los Angeles opened as 3-point chalk in The SuperBook's odds for NFL Week 1. In mid-June, there was a juice adjustment to Rams -3 (even) and on Aug. 6, L.A. ticked down to -2.5.

The total opened at 46.5, went to 46 within a few days, then over the past three weeks dipped to 45/44.5/44.

Baltimore Ravens vs. Buffalo Bills Odds

• Opening point spread: Bills -1.5
• Opening moneyline: Bills -120/Ravens even
• Opening total: Over/Under 53.5 points scored
• Time: 8:20 p.m. ET Sunday, Sept. 7 (NBC)

UPDATE 10 P.M. ET SUNDAY: Buffalo (15-5 SU/12-8 ATS) reached the AFC Championship Game, but again found Kansas City to be its nemesis. The Bills were 1.5-point road underdogs and fell 32-29 on a Chiefs field goal with 3:33 remaining.

Baltimore (13-6 SU/11-7-1 ATS) gets a speedy rematch with the Bills, who ended the Ravens' 2024-25 season in the Divisional Round. Lamar Jackson & Co. were actually 1.5-point road favorites, but lost 27-25. The Ravens got a late TD to pull within 27-25, but the 2-point attempt failed.

The Ravens-Bills line is actually moving toward Baltimore in The SuperBook's NFL odds Week 1 market. Buffalo opened -1.5, and on July 9, the number dipped to -1. It stuck there until Aug. 18, when The SuperBook moved to pick 'em.

"Ticket count is about even, but there's more money on the Ravens so far," SuperBook risk manager Casey Degnon said of spread action. "I think the public will be split on this game. But I anticipate the bigger bets will continue to be on the Ravens, and we'll need the Bills."

The total opened at 53.5, spent most of the summer at 52.5 and went to 52 Aug. 20.

"More tickets and money on the Under, and we also took a respected bet on Under 53.5," Degnon said.

Minnesota Vikings vs. Chicago Bears Odds

• Opening point spread: Bears -1.5
• Opening moneyline: Bears -115/Vikings -105
• Opening total: Over/Under 45 points scored
• Time: 8:15 p.m. ET Monday, Sept. 8 (ABC/ESPN)

UPDATE 10 P.M. ET SUNDAY: Minnesota (14-4 SU/11-6-1 ATS) had a surprisingly strong 2024-25 season, contending with Detroit for the NFC's No. 1 seed throughout. The Vikes settled for a Wild Card bid and saw their season end with a 27-9 neutral-site loss as 2.5-point favorites vs. the L.A. Rams.

That ended a surprisingly successful one-year stint for QB Sam Darnold in Minnesota. The Vikings are moving on to J.J. McCarthy, the former Michigan standout who missed last year's rookie season due to a knee injury.

Chicago (5-12 SU/9-7-1 ATS) had another dismal season, firing coach Matt Eberflus the day after Thanksgiving. But there's optimism with new coach Ben Johnson, who left his post as Lions offensive coordinator to take the reins in Chicago.

This line jumped the fence early on at The SuperBook. The Bears opened -1.5 on May 14, and the number went to pick on June 4. Since Aug. 5, the spread has toggled between Vikings -1/-1.5 a couple times, and it's now Minnesota -1.

"We opened the Bears as a favorite and took a sharp bet on the Vikes +1.5," SuperBook risk manager Casey Degnon said. "Since then, the Vikings have moved to a favorite and are taking more bets and money.

"As of now, we're rooting for the bears. But I would not be surprised if we start to see more Bears money as we get closer to kickoff."

The total is down to 43 from a 45 opener.

"This game is all Under money so far," Degnon said..

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson