NFL Week 15 Odds: Lines, Spreads, Betting Trends for Every Game

Patrick Everson Sports Betting Expert

12 minute read

2025 NFL Week 15 Odds

NFL Week 15 odds feature a handful of games with long-term implications. Playoff positions continue to shake out, and it could be make-or-break for some outfits.

Leading the way on the Week 15 NFL odds board: Buffalo Bills vs. New England Patriots. Close behind: Detroit Lions vs. Los Angeles Rams and Los Angeles Chargers vs. Kansas City Chiefs.

Here’s everything you need to know about NFL odds Week 15: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on NFL Week 15 odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Gary A. Vasquez/Imagn Images)

2025 NFL Odds for Week 15

Atlanta Falcons vs. Tampa Bay Buccaneers Odds

• Opening point spread: Buccaneers -5.5
• Opening moneyline: Buccaneers TBA/Falcons TBA
• Opening total: Over/Under 44.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

OPENING ODDS UPDATE: Tampa Bay (7-6 SU/5-8 ATS), an early-season darling, has fallen apart of late, going 1-4 SU and 0-5 ATS in its last five outings. Arguably no result was worse than in Week 14, when the Bucs lost to lowly New Orleans 24-20 as 7.5-point home favorites.

Atlanta (5-9 SU and ATS) was right in it against Seattle at halftime, albeit in a snoozer of a game, tied at 6. But the Falcons gave up 31 of the final 34 points of the game and got blown out 37-9 as 6.5-point home pups.

Atlanta is 1-7 SU in its last eight games.

The SuperBook opened Falcons-Bucs at Tampa Bay -5.5 in NFL Week 15 odds.

"Our lookahead line last week was Atlanta +6. We'll probably end up needing Atlanta in this game," SuperBook vice president John Murray said Sunday night.

Buffalo Bills vs. New England Patriots Odds

• Opening point spread: Bills -1
• Opening moneyline: Bills TBA/Patriots TBA
• Opening total: Over/Under 49.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: New England (11-2 SU/9-4 ATS), coming off its bye week, is the second-best spread covering outfit in the league, behind only Seattle. The Patriots are also on a 10-game winning streak (8-2 ATS).

In Week 12, the Pats coasted past the Giants 33-15 laying 7 points at home.

Buffalo (9-4 SU/6-7 ATS) was in trouble much of the way vs. Cincinnati in Week 14. The Bills trailed 14-3 early and 28-18 in the fourth quarter. But a 40-yard Josh Allen TD run, followed by a Christian Benford 63-yard interception-return TD, boosted Buffalo to a 39-34 overtime victory.

Still, the Bills failed to cash as 6-point home favorites.

Bills-Patriots opened Sunday night with Buffalo a 1-point road favorite in The SuperBook's Week 15 NFL odds. That's a flip from last week's lookahead line, which started at New England -2.5 and went to -2/-1.5.

No matter where the number lands, SuperBook VP John Murray is excited for this one.

"This shapes up to one of the biggest early-window games of the season," Murray said. "I think we’ll end up needing New England. As hot as the Patriots are, Buffalo remains one of the public's favorite teams to back, because that offense with Josh Allen is so explosive."

Los Angeles Chargers vs. Kansas City Chiefs Odds

• Opening point spread: Chiefs -4.5
• Opening moneyline: Chiefs TBA/Chargers TBA
• Opening total: Over/Under 44.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Kansas City (6-7 SU and ATS) is in dire straits, looking squarely at missing the playoffs. Which is wild to think about, since this team has been to the last seven AFC Championship Games, leading to five Super Bowl appearances and three wins.

In the Week 14 Sunday night game, the Chiefs mustered just 10 points in a 20-10 loss to Houston as 4.5-point home favorites. K.C. is 1-4 SU/0-5 ATS in its last five games. The Chiefs need to win their last four games and get a lot of help to reach the postseason.

Los Angeles (8-4 SU/6-6 ATS) also isn't yet out of Week 14. The Chargers host the Eagles on Monday night.

Still, The SuperBook opened Chargers-Chiefs at K.C. -4.5 Sunday evening. About an hour afterward, Chargers-Chiefs was taken off the board, once Texas-Chiefs kicked off. Chargers-Chiefs will go back up Monday.

"It seems like Kansas City has its backs to the wall every week," SuperBook VP John Murray said. "This is another solid 1 p.m. ET game for handle."

Baltimore Ravens vs. Cincinnati Bengals Odds

• Opening point spread: Ravens -2.5
• Opening moneyline: Ravens TBA/Bengals TBA
• Opening total: Over/Under 51.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Baltimore (6-7 SU/5-8 ATS) followed up a season-saving five-game win streak with back-to-back losses. In Week 14, the Ravens closed as 5.5-point home favorites and fell outright to Pittsburgh 27-22. Baltimore had a late touchdown overturned on review.

Cincinnati (4-9 SU/6-7 ATS) had a great chance to pull a second straight upset behind Joe Burrow. The Bengals led at Buffalo well into the fourth quarter, then blew up.

Cincy allowed a 40-yard Josh Allen TD run, then Burrow got picked off by Christian Benford, who ran it back 63 yards for a TD. A 28-18 Bengals lead quickly became a 32-28 deficit, en route to a 39-34 loss as 6-point underdogs.

Ravens-Bengals opened at Baltimore -2.5 in The SuperBook's NFL odds Week 15 market. There was no early movement Sunday night.

"The Ravens are a tough team to figure out. They continue to play to a very high number, despite obvious issues Lamar Jackson is having. I still think the public will back them again at that -2.5 number," SuperBook vice president John Murray said.

Cleveland Browns vs. Chicago Bears Odds

• Opening point spread: Bears -7
• Opening moneyline: Bears TBA/Browns TBA
• Opening total: Over/Under 39.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Chicago (9-4 SU/7-5-1 ATS) saw its impressive 9-1 SU run come to an end in Week 14. Caleb Williams threw an interception in the end zone with 22 seconds remaining in the Bears' 28-21 loss to Green Bay as 6.5-point road underdogs.

The setback ended Chicago's five game win streak (4-1 ATS).

Cleveland (3-10 SU/5-8 ATS) couldn't take advantage of rookie QB Shedeur Sanders' huge Week 14 effort. Sanders threw for 364 yards and three touchdowns vs. Tennessee, but the Browns fell short 31-29 when a 2-point attempt failed, following a late touchdown.

Cleveland was a 3.5-point home favorite.

In NFL Week 15 odds, the Bears opened -7 Sunday night at The SuperBook, with no early movement.

Las Vegas Raiders vs. Philadelphia Eagles Odds

• Opening point spread: Eagles -12.5
• Opening moneyline: Eagles TBA/Raiders TBA
• Opening total: Over/Under 38.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Philadelphia (8-4 SU/7-5 ATS) still has Week 14 work to do. The Eagles visit the Chargers on Monday Night Football.

Las Vegas (2-11 SU/5-8 ATS) is on a seven-game nosedive. In Week 14, the Raiders lost to Denver 24-17 catching 8.5 points at home. On the plus side, the Raiders covered the spread by kicking a field goal as time expired.

Philly opened -12.5 vs. Las Vegas in The SuperBook's Week 15 NFL odds, with no Sunday night movement.

Washington Commanders vs. New York Giants Odds

• Opening point spread: Giants -1.5
• Opening moneyline: Giants TBA/Commanders TBA
• Opening total: Over/Under 46 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Washington (3-9 SU and ATS) didn't get the boost anticipated from the return of QB Jayden Daniels. The Commanders got shellacked 31-0 at Minnesota, after closing as 1-point underdogs.

Daniels completed just 9 of 20 passes for 78 yards. He exited after a third-quarter interception, on which he was blocked during the return and landed hard on the left elbow he dislocated last month.

New York (2-11 SU/7-6 ATS) is coming off a much-needed bye, after losing seven consecutive games. In Week 13, the Giants fell at New England 33-15 catching 7 points.

Commanders-Giants opened at New York -1 in The SuperBook's NFL odds Week 15 market. There was no early movement Sunday night.

New York Jets vs. Jacksonville Jaguars Odds

• Opening point spread: Jaguars -11.5
• Opening moneyline: Jaguars TBA/Jets TBA
• Opening total: Over/Under 42.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Jacksonville (9-4 SU and ATS) is quietly on a four-game run that has put it atop the AFC South. In Week 14, the Jags beat Indianapolis 36-19 as 2.5-point home underdogs. Jacksonville was aided by Indy's loss of QB Daniel Jones (Achilles) in the second quarter.

New York (3-10 SU/5-8 ATS) sealed its Week 14 fate early against Miami. The Jets dug themselves into a 21-0 first-quarter hole en route to a 34-10 loss catching 2.5 points at home.

The Jags opened -11.5 vs. the Jets on Sunday night at The SuperBook, with no early moves.

Arizona Cardinals vs. Houston Texans Odds

• Opening point spread: Texans -7.5
• Opening moneyline: Texans TBA/Cardinals TBA
• Opening total: Over/Under 43.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Houston (8-5 SU and ATS) is on a very well-timed five-game winning streak (4-1 ATS). In the Week 13 Sunday night game, the Texans went to Kansas City as 4.5-point underdogs and exited with a 20-10 victory.

That might well have been the knockout punch to the Chiefs' playoff hopes.

On the flip side, Arizona (3-10 SU/6-7 ATS) has lost five in a row and 10 of its last 11 (5-6 ATS). In Week 14, the Cardinals got blown out 45-17 getting 9.5 points at home against the Rams.

About an hour before Texans-Chiefs kicked off, The SuperBook opened Cards-Texans at Houston -7.5. Once Texans-Chiefs got underway, Cards-Texans came off the board, and it will go back up Monday morning.

Detroit Lions vs. Los Angeles Rams Odds

• Opening point spread: Rams -4.5
• Opening moneyline: Rams TBA/Lions TBA
• Opening total: Over/Under 52 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Los Angeles (10-3 SU/9-4 ATS) rebounded just fine from a stunning Week 13 loss at Carolina. The Rams blew out Arizona 45-17 laying 9.5 points on the road. L.A. is 7-1 SU/6-2 ATS in its last eight games.

Detroit (9-5 SU/8-6 ATS) have alternated SU wins and losses over their last nine games (4-5 ATS), looking nothing like the spread-covering machine it had been since the middle of the 2022-23 season. Still, in Week 14, the Lions dumped Dallas 44-30 as 3.5-point home favorites.

L.A. opened -4.5 vs. Detroit in The SuperBook's NFL Week 15 odds. That number is stable Sunday night, but the total is out to 53.5 from a 52 opener, with a stop at 53 along the way.

"The Rams are probably the highest power-rated team in the league right now. I think we’ll need Detroit and probably the Under," SuperBook vice president John Murray said.

Indianapolis Colts vs. Seattle Seahawks Odds

• Opening point spread: Seahawks -10
• Opening moneyline: Seahawks TBA/Colts TBA
• Opening total: Over/Under 43.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Seattle (10-3 SU and ATS) continues to be a winner for bettors, holding the best spread-covering mark in the NFL. In Week 14, the Seahawks were in a 6-6 halftime tie at Atlanta, then blew up for 31 second-half points in a 37-9 rout as 6.5-point road favorites.

Indianapolis (8-5 SU/6-7 ATS) is on an ill-timed three game slide, and it could get worse. In Week 14, the Colts tumbled to Jacksonville 36-19 laying 2.5 points on the road.

Worse, Indy QB Daniel Jones suffered an Achilles injury in the second quarter, and his season is done. The Colts' eye-catching 8-2 SU start is a memory, as they trail Jacksonville in the division.

With the Colts way shorthanded at QB, now starting Riley Leonard, The SuperBook opened Seattle as 10-point home chalk in Week 15 NFL odds.

"The lookahead line last week was more like Seahawks -4/-4.5. Now it’s at 10, with the injury to Colts QB Daniel Jones," SuperBook VP John Murray said. "Seattle is quietly one of the best teams in the league, and the wheels seem to have come off for Indianapolis, after that dream start."

The spread is stable Sunday night, while the total nudged from 43.5 to 43.

Green Bay Packers vs. Denver Broncos Odds

• Opening point spread: Packers -1.5
• Opening moneyline: Packers TBA/Broncos TBA
• Opening total: Over/Under 41.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Denver (11-2 SU/5-8 ATS) keeps getting it done on the field, if not for spread bettors. In Week 14, the Broncos topped the Raiders 24-17, failing to cover as 8.5-point road favorites when Las Vegas kicked a field goal as time expired.

Denver is on a 10-game SU win streak, but is 1-3 ATS in its last four.

Green Bay (9-3-1 SU/6-7 ATS) are on a four-game upswing and have cashed three in a row. In Week 14, the Packers held off Chicago 28-21 as 6.5-point road favorites. The Pack clinched the win on Keisean Nixon's interception in the end zone with 22 seconds remaining.

Packers-Broncos opened at Green Bay -1.5 on the road, in The SuperBook's NFL odds Week 15 market. That number is stable Sunday night.

"Last week, this game was bet up a little from our lookahead number of pick. to Packers -1. Now, we have settled at Packers -1.5," SuperBook VP John Murray said. "I expect to need Denver. The public still doesn’t fully trust the Broncos, and Green Bay has won back-to-back high profile games."

Tennessee Titans vs. San Francisco 49ers Odds

• Opening point spread: 49ers -12.5
• Opening moneyline: 49ers TBA/Titans TBA
• Opening total: Over/Under 43.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: San Francisco (9-4 SU and ATS) is fresh off its bye week and riding a three-game SU and ATS upswing. In Week 13, the 49ers rolled over Cleveland 26-8 giving 5 points on the road.

Tennessee (2-11 SU/5-9 ATS) got a very rare win in Week 14, and as a road 'dog no less. The Titans got 161 rushing yards and two TDs from Tony Pollard and outlasted Cleveland 31-29 as 3.5-point pups.

The SuperBook opened San Fran as 12.5-point home chalk in NFL Week 15 odds. There's been no movement Sunday night.

Carolina Panthers vs. New Orleans Saints Odds

• Opening point spread: Panthers -3
• Opening moneyline: Panthers TBA/Saints TBA
• Opening total: Over/Under 39 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Carolina (7-6 SU/8-5 ATS) had a Week 13 bye, after posting one of the bigger upsets of the season. The Panthers were 10-point home underdogs to the Rams in Week 13 and pulled off a 31-28 upset.

New Orleans (3-10 SU/5-8 ATS) notched the biggest upset of Week 14. The Saints were 7.5-point underdogs at Tampa Bay, but hung around the whole way and won 24-20.

Carolina opened -3 vs. New Orleans in The SuperBook's Week 15 NFL odds. Sunday night brought only a juice adjustment, to Panthers -3 (even).

Minnesota Vikings vs. Dallas Cowboys Odds

• Opening point spread: Cowboys -6.5
• Opening moneyline: Cowboys TBA/Vikings TBA
• Opening total: Over/Under 47.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

OPENING ODDS UPDATE: Dallas (6-6-1 SU/7-6 ATS) is on the brink of elimination from playoff contention, after its three-game win streak ended in the Week 14 Thursday nighter. The Cowboys closed as 3.5-point 'dogs at Detroit and lost 44-30.

Minnesota (5-8 SU and ATS) halted a season-killing 1-6 SU and ATS purge in Week 14. The Vikings were 1-point home favorites vs. Washington and rumbled to a 31-0 shutout victory.

The SuperBook opened Vikings-Cowboys opened at Dallas -6.5, with no early movement Sunday night.

Miami Dolphins vs. Pittsburgh Steelers Odds

• Opening point spread: Steelers -3.5
• Opening moneyline: Steelers TBA/Dolphins TBA
• Opening total: Over/Under 42 points scored
• Time: 8:15 p.m. ET Monday (ESPN)

OPENING ODDS UPDATE: Pittsburgh (7-6 SU/7-5-1 ATS) halted a 1-3 slide with a much-needed win 27-22 win over division rival Baltimore. The Steelers, 5.5-point road underdogs, held on after a late Ravens touchdown was overturned on review.

Miami (6-7 SU/7-6 ATS) brings a four-game win streak into Week 15 (3-1 ATS). In Week 14, the Dolphins thumped the Jets 34-10 as 2.5-point road favorites.

Dolphins-Steelers opened at Pittsburgh -3.5 Sunday night in The SuperBook's NFL Week 15 odds, with no early movement.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson