NFL Week 17 Odds: Lines, Spreads, Betting Trends for Every Game

Patrick Everson Sports Betting Expert

12 minute read

2025 NFL Week 17Odds

NFL Week 17 odds include a full slate of 16 games, played on four days, including a Christmas Day gift of a tripleheader. And of course, many matchups hold playoff implications.

Among the most intriguing contests in Week 17 NFL odds: Philadelphia Eagles vs. Buffalo Bills, Baltimore Ravens vs. Green Bay Packers and Chicago Bears vs. San Francisco 49ers.

Here’s everything you need to know about NFL odds Week 17: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on NFL Week 17 odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature Image: Kevin Jairaj/Imagn Images)

2025 NFL Odds for Week 17

Dallas Cowboys vs. Washington Commanders Odds

• Opening point spread: Cowboys -3.5
• Opening moneyline: Cowboys TBA/Commanders TBA
• Opening total: Over/Under 50.5 points scored
• Time: 1 p.m. ET Thursday (Netflix)

OPENING ODDS UPDATE: Dallas (6-8-1 SU/7-8 ATS) can now officially wave goodbye to a postseason appearance this season. In Week 16, the Cowboys were in it halftime, down 21-17 to the Chargers, but didn't score again in a 34-17 loss laying 1.5 points at home.

Washington (4-11 SU/5-10 ATS) looked as if it might have Philadelphia in a little trouble in Week 16, leading 10-7 at halftime. But the Commanders gave up the next 22 points and lost 29-18 as 7-point home underdogs.

QB Marcus Mariota, subbing for the injured Jayden Daniels, exited in the third quarter with a hand injury and didn't return. Josh Johnson finished out the game, and Mariota is questionable vs. the Cowboys, on a short week.

The SuperBook opened Dallas -3.5 in NFL Week 17 odds, and that line was on the move early Sunday night. The Cowboys are already out to -5.5.

"It’s hard to determine the motivation level of both teams. But they are rivals, and this is a national game," SuperBook vice president John Murray said.

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Detroit Lions vs. Minnesota Vikings Odds

• Opening point spread: Lions -5.5
• Opening moneyline: Lions TBA/Vikings TBA
• Opening total: Over/Under 46.5 points scored
• Time: 4:30 p.m. ET Thursday (Netflix)

OPENING ODDS UPDATE: Detroit (8-7 SU/7-8 ATS) has its playoff hopes hanging by an ever-disintegrating thread after a crazy Week 16 loss. The Lions fell to Pittsburgh 29-24 giving 7.5 points at home, their third setback in the last four games.

Detroit had two plays called as touchdowns on their final-minute drive, but both were negated by offensive pass-interference calls. The second one was on fourth-and-goal, with time expiring on the play, as well.

Minnesota (7-8 SU and ATS) is on a three-game SU and ATS run, despite losing QB J.J. McCarthy for the second half of its Week 16 game at the New York Giants. The Vikings got a field goal with 4:15 remaining to clinch a 16-13 win as 2.5-point favorites.

McCarthy suffered an injury to his right (throwing) hand, but X-rays were negative. He's questionable vs. Detroit at the moment, and The SuperBook opened the Lions as 5.5-point road favorites in Week 17 NFL odds.

"It's a game similar to the first game of Christmas Day. The Vikings have a backup QB, and the motivation level is hard to read for Detroit," SuperBook VP John Murray said.

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Denver Broncos vs. Kansas City Chiefs Odds

• Opening point spread: Broncos -11.5
• Opening moneyline: Broncos TBA/Chiefs TBA
• Opening total: Over/Under 37.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

OPENING ODDS UPDATE: Denver (12-3 SU/6-9 ATS) had its surprising win streak end in Week 16, after 11 consecutive victories. The Broncos tied Jacksonville at 17 early in the third quarter, but gave up the next 17 points in a 34-20 loss giving 3.5 points at home.

Kansas City (6-9 SU/5-10 ATS) continues to see its season circle the drain. A week after losing Patrick Mahomes (torn ACL), backup Gardner Minshew also suffered what's feared to be a torn ACL, on just the third play of the Week 16 game at Tennessee.

The Chiefs went on to a 26-9 loss as 3-point road favorites vs. the lowly Titans. K.C. has dumped four in a row and is 1-6 SU/0-7 ATS in its last seven games. And the Chiefs are now down to third-string QB Chris Oladokun.

"We opened the Broncos -11.5, after seeing the Chiefs' performance today," The SuperBook's John Murray said early Sunday evening. "It’s going to be hard for Kansas City to score with a third-string QB against the Denver defense."

Within a couple hours, the Broncos advanced to -12.5.

Houston Texans vs. Los Angeles Chargers Odds

• Opening point spread: Pick
• Opening moneyline: Texans TBA/Chargers TBA
• Opening total: Over/Under 40 points scored
• Time: 4:30 p.m. ET Saturday (NFL Network)

OPENING ODDS UPDATE: Houston (10-5 SU and ATS) stretched its winning streak to seven games in Week 16, but got much more fight than expected. The Texans closed as 14-point favorites vs. Las Vegas and eked out a 23-21 victory.

Los Angeles (11-4 SU/9-6 ATS) is on a four-game run, now just a game behind Denver in the AFC West. In Week 16, the Chargers pulled away from Dallas in the second half for a 34-17 victory catching 1.5 points on the road.

"We’re sitting at pick ’em now. Both teams have been playing well lately," SuperBook vice president John Murray said Sunday night.

Baltimore Ravens vs. Green Bay Packers Odds

• Opening point spread: Off
• Opening moneyline: Packers TBA/Ravens TBA
• Opening total: Over/Under TBA points scored
• Time: 8 p.m. ET Saturday (Peacock)

OPENING ODDS UPDATE: Green Bay (9-5-1 SU/6-9 ATS) snatched defeat from the jaws of victory in Week 16, blowing a 16-6 lead in the waning minutes as 1.5-point underdogs at Chicago.

The Packers gave up a field goal with 1:59 remaining, failed to cover an onside kick, then gave up a touchdown with 24 seconds remaining. That sent the game to overtime tied at 16. Green Bay then fumbled on the opening OT possession and lost 22-16 on a 46-yard D.J. Moore TD catch.

Adding injury to insult, Packers QB Jordan Love exited in the first half with a concussion.

Baltimore (7-7 SU/6-8 ATS) first has to complete its Week 16 task. The Ravens are playing right now against the visiting Patriots on Sunday Night Football.

With Love's status uncertain and Baltimore in the Week 16 Sunday night game, The SuperBook hasn't posted the Ravens-Packers line yet.

Jacksonville Jaguars vs. Indianapolis Colts Odds

• Opening point spread: Jaguars -6.5
• Opening moneyline: Jaguars TBA/Colts TBA
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Jacksonville (11-4 SU and ATS) is on a well-timed 6-0 SU and ATS tear, with its latest victim the NFL's hottest team. The Jaguars knocked out Denver 34-20 as 3.5-point road underdogs in Week 16, halting the Broncos 11-game win streak.

Indianapolis (8-6 SU and ATS) still has Week 16 work to do. The Colts host San Francisco in the Monday night game.

The SuperBook went ahead and opened Jags-Colts at Jacksonville -6.5 on the road, with no movement Sunday night.

Seattle Seahawks vs. Carolina Panthers Odds

• Opening point spread: Seahawks -7
• Opening moneyline: Seahawks TBA/Panthers TBA
• Opening total: Over/Under 42.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Seattle (12-3 SU/11-4 ATS) has the NFC's No. 1 seed and the league's best spread-covering mark. In Week 16, the Seahawks overcame a 30-14 fourth-quarter deficit, upending the Rams 38-37 in overtime, winning on a 2-point conversion.

That allowed Seattle to overtake L.A. for the top playoff seed.

Carolina (8-7 SU/9-6 ATS) is now in the driver's seat to win the NFC South. In Week 16, the Panthers were 3-point home 'dogs and edged Tampa Bay 23-20 on a late field goal, snapping a tie atop the division.

Seahawks-Panthers opened at Seattle -7 in The SuperBook's NFL Week 17 odds. The line hasn't moved as of late Sunday night.

New England Patriots vs. New York Jets Odds

• Opening point spread: Patriots -11.5
• Opening moneyline: Patriots TBA/Jets TBA
• Opening total: Over/Under 42 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: New England (11-3 SU/9-5 ATS) is in the midst of a tough Week 16 assignment, visiting Baltimore on Sunday Night Football.

New York (3-12 SU/5-10 ATS) was only down 9-6 at halftime in New Orleans. But those two first-half field goals were all the Jets mustered in a 29-6 loss getting 6.5 points.

Patriots-Jets opened at New England -11.5 in The SuperBook's Week 17 NFL odds. Pats-Jets then came off the board Sunday night, once Pats-Ravens kicked off. Patriots-Jets will go back up Monday morning.

Tampa Bay Buccaneers vs. Miami Dolphins Odds

• Opening point spread: Buccaneers -4.5
• Opening moneyline: Buccaneers TBA/Dolphins TBA
• Opening total: Over/Under 47.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Tampa Bay (7-8 SU/5-10 ATS) is a long way from the 6-2 mark it had through eight games. In Week 16, the misery continued as the Bucs lost to Carolina 23-20 giving 3 points on the road. Tampa is on a 1-6 SU/0-7 ATS nosedive.

Miami (6-9 SU/7-8 ATS), with rookie QB Quinn Ewers starting, hung around until halftime against Cincinnati, trailing 17-14. But the Dolphins then gave up the next 28 points in a 45-21 loss as 3.5-point home pups.

Bucs-Dolphins opened with Tampa Bay 4.5-point road chalk in The SuperBook's NFL odds Week 17 market. There was no movement Sunday night.

Pittsburgh Steelers vs. Cleveland Browns Odds

• Opening point spread: Steelers -4.5
• Opening moneyline: Steelers TBA/Browns TBA
• Opening total: Over/Under 34.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Pittsburgh (9-6 SU/9-5-1 ATS) held on for a huge Week 16 win with a crazy ending. The Steelers were 7.5-point 'dogs at Detroit and pulled off a 29-24 upset.

Jaylen Warren had two 45-yard touchdown runs in the fourth quarter to give Pittsburgh a 29-17 lead. But the Steelers hung on in the final minute when Detroit had two touchdowns negated by offensive pass interference penalties.

Cleveland (3-12 SU/6-9 ATS) gave Buffalo a harder test than expected in Week 16. The Browns fell short 23-20 as 10.5-point home underdogs.

The SuperBook opened Pittsburgh -4.5 vs. Cleveland in NFL Week 17 odds, with no movement Sunday night.

Arizona Cardinals vs. Cincinnati Bengals Odds

• Opening point spread: Bengals -7
• Opening moneyline: Bengals TBA/Cardinals TBA
• Opening total: Over/Under 50.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Cincinnati (5-10 SU/7-8 ATS) put up 28 straight points to open the second half, pulling away from Miami for a 45-21 rout laying 3.5 points on the road. The Bengals are 4-1 ATS in their last five games (2-3 SU).

Arizona (3-12 SU/6-9 ATS) has lost seven in a row and 12 of its last 13 (5-8 ATS). In Week 15, the Cards had early leads of 10-0 and 13-3 vs. Atlanta, but couldn't maintain in a 26-19 loss catching 2.5 points at home.

Sunday night, The SuperBook opened Cincy -7, with no Sunday night movement. However, the total was very much on the move early, advancing from 50.5 to 51.5/52/52.5.

New Orleans Saints vs. Tennessee Titans Odds

• Opening point spread: Saints -3
• Opening moneyline: Saints TBA/Titans TBA
• Opening total: Over/Under 37.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: New Orleans (5-10 SU/7-8 ATS) was in the rare role of favorite and made it stick in Week 16. The Saints closed -6.5 vs. the hapless New York Jets and rolled to a 29-6 victory.

Tennessee (3-12 SU/7-8 ATS) was the first beneficiary of a Kansas City team without Patrick Mahomes. And without Gardner Minshew, for that matter, as K.C.'s backup QB suffered a knee injury on the first possession of Sunday's game.

The Titans went on to a 26-9 victory as 3-point home underdogs, their second win the last three games.

Saints-Titans opened at New Orleans -3 in The SuperBook's Week 17 NFL odds. That line is stable Sunday night.

New York Giants vs. Las Vegas Raiders Odds

• Opening point spread: Giants -1.5
• Opening moneyline: Giants TBA/Raiders TBA
• Opening total: Over/Under 41.5 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: New York (2-13 SU/7-8 ATS) hung around against Minnesota in Week 16, but ultimately took its ninth straight loss. The Giants fell 16-13 getting 2.5 points at home.

Las Vegas (2-13 SU/6-9 ATS) has also lost nine in a row, though the Silver and Black gave Houston a better-than-anticipated game. The Raiders closed as 14-point road 'dogs and came up just short 23-21.

There was nominal movement in the Giants-Raiders line Sunday night. The SuperBook opened New York -1.5 on the road and went to -1 about 2.5 hours later.

Philadelphia Eagles vs. Buffalo Bills Odds

• Opening point spread: Bills -2.5
• Opening moneyline: Bills TBA/Eagles TBA
• Opening total: Over/Under 45.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Buffalo (11-4 SU/7-8 ATS) has won four in a row while continuing to pursue New England in the AFC East. In Week 16, the Bills fended off Cleveland 23-20, well short of covering as 10.5-point road favorites.

Philadelphia (10-5 SU/9-6 ATS) had a sluggish first half at Washington in Week 16, trailing 10-7 at the break. But the Eagles scored the next 22 points – three TDs and a 2-point conversion – and coasted to a 29-18 win laying 7 points.

The SuperBook opened Eagles-Bills at Buffalo -2.5 in NFL Week 17 odds, with no movement Sunday night.

"I think the Bills almost got caught looking ahead to this game today against the Browns," SuperBook VP John Murray said Sunday night. "Eagles-Bills sets up to be a good two-way game."

The total nudged from 45.5 to 45 Sunday night.

Chicago Bears vs. San Francisco 49ers Odds

• Opening point spread: 49ers -3
• Opening moneyline: 49ers TBA/Bears TBA
• Opening total: Over/Under 50.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

OPENING ODDS UPDATE: Chicago (11-4 SU/9-5-1 ATS) pulled off an improbable Week 16 comeback at home vs. Green Bay. The Bears trailed 16-6, but in the final two minutes, got a field goal, recovered an onside kick and scored a touchdown to tie it at 16.

Chicago then forced a fumble on the first possession of overtime and won 22-16 on a 46-yard TD pass from Caleb Williams to D.J. Moore. The Bears also covered as 1.5-point favorites.

San Francisco (10-4 SU and ATS) isn't yet out of Week 16. The 49ers host Chicago on Monday Night Football.

San Fran opened as 3-point home chalk vs. Chicago, and the line is stable Sunday night.

"Not much action yet, but I think this will be a good two-way game like Philly-Buffalo," SuperBook vice president John Murray said.

Los Angeles Rams vs. Atlanta Falcons Odds

• Opening point spread: Rams -7.5
• Opening moneyline: Rams TBA/Falcons TBA
• Opening total: Over/Under 48.5 points scored
• Time: 8:15 p.m. ET Monday (ESPN)

OPENING ODDS UPDATE: Los Angeles (11-4 SU/10-5 ATS) was in prime position to keep the NFC's No. 1 seed in Week 16. The Rams took a 30-14 lead on a touchdown early in the fourth quarter at Seattle. But L.A. let the Seahawks back in, getting forced to overtime in a 30-30 tie.

Both teams then put up touchdowns, but the Rams fell 38-37 as 1.5-point underdogs on Seattle's successful 2-point conversion.

Atlanta (6-9 SU and ATS) is on a modest two-game SU and ATS upswing. In Week 16, the Falcons were in early holes of 10-0 and 13-3 at Arizona, but rallied for a 26-19 victory giving 2.5 points.

The SuperBook opened Rams-Falcons at Los Angeles -7.5, with no movement Sunday night. The total saw a modest move, inching from 48.5 to 49.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson