Last Updated Dec 26, 2021, 6:36 PM

Indianapolis Colts vs. Arizona Cardinals Predictions, Odds, Picks

Dec. 25, 2021
Dan Dobish
VI Betting Expert

The Indianapolis Colts (8-6) travel to meet the Arizona Cardinals (10-4) in a Saturday AFC vs. NFC matchup at State Farm Stadium in Glendale, Ariz. Kickoff is scheduled for 8:15 p.m. ET, and the game can be viewed on NFL Network.

Score Prediction

Colts 34, Cardinals 26

Best Bets

Colts -105 ML at BetMGM

Over 49 (-110) at BetMGM

Indianapolis Colts vs. Arizona Cardinals Predictions

Remember in years past when these Saturday games didn't really have much impact on playoff races? Maybe one of the teams was in the mix, and the other was struggling with a losing record, but we watched anyway because, well, football. And betting. Now, the front end of Saturday's double dip has playoff implications for both teams, and the nightcap certain does, too.

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