Dec. 25, 2021
The Indianapolis Colts (8-6) travel to meet the Arizona Cardinals (10-4) in a Saturday AFC vs. NFC matchup at State Farm Stadium in Glendale, Ariz. Kickoff is scheduled for 8:15 p.m. ET, and the game can be viewed on NFL Network.
Score Prediction
Colts 34, Cardinals 26
Best Bets
Colts -105 ML at BetMGM
Over 49 (-110) at BetMGM
Indianapolis Colts vs. Arizona Cardinals Predictions
Remember in years past when these Saturday games didn't really have much impact on playoff races? Maybe one of the teams was in the mix, and the other was struggling with a losing record, but we watched anyway because, well, football. And betting. Now, the front end of Saturday's double dip has playoff implications for both teams, and the nightcap certain does, too.
We may be compensated by the company links provided on this page. Read more
