Duke vs Houston Picks, Odds | NCAA Tourney Sweet 16 Prediction

The Sweet 16 of NCAA Tourney resumes this Friday -- and the third matchup of the day we'll be breaking down is Duke vs Houston, which is scheduled for 9:39 p.m. ET on CBS.

The Blue Devils are four-point underdogs on the spread in Friday's contest; with the game total set at over/under 134 at most sportsbooks.

Here's everything you need to know about Duke vs Houston -- the latest betting odds, as well as our expert picks and prediction for this Sweet 16 NCAA Tournament matchup on Friday, March 29.

When you're ready to bet, use our Caesar's Sportsbook promo code to get potential bonus bets!

Duke vs Houston Odds

DUKE @ UH Odds

Duke vs Houston Picks & Prediction

Duke has taken care of business in its first two games against Vermont and James Madison to reach the Sweet 16 for the first time under head coach Jon Scheyer.

The Blue Devils are making a huge jump in class here following consecutive blowouts, but face top-seeded Houston, who survived a major scare from Texas A&M in a 100-95 overtime triumph on Sunday.

The Cougars were in control with 1:30 left by leading, 82-71, but the Aggies outscored Houston, 15-4 to force overtime. Houston staved off A&M, but failed to cover as 8.5-point favorites.

Duke has lost in both opportunities as an underdog this season to North Carolina and Wake Forest, while owning a dreadful 1-5 SU/ATS mark as a 'dog under Scheyer.

Houston ranks 10th in the country in defending the 3-point shot at 30%, while limiting opponents to 43.1% shooting on 2-point tries, which is 3rd.

Since allowing Iowa State to convert on 57.1% of its 2-point attempts in the Big 12 championship, Houston has yielded 39.3% shooting to Longwood and 40.4% shooting to Texas A&M on 2-pointers.

Duke's Jared McCain shot 7-of-26 from 3-point range in his first six games in March before knocking down 8-of-11 from downtown against James Madison.

Look for Houston to put together a strong defensive effort and slow down Duke to advance to the Elite Eight.

Pick: Houston -4 (-110)

Click this link for betting picks and predictions for all eight Sweet 16 matchups of the NCAA Tourney!

Duke vs Houston Game Time & TV Channel

Date: Friday, March 29
Matchup: ACC vs Big 12
Venue: American Airlines Center
Location: Dallas, TX
Time-TV: CBS, 9:39 p.m. ET

Duke vs Houston Betting Stats

1) Houston Cougars
(Big 12, At-Large)

  • Futures: +500
  • Region: +120
  • SU: 30-4
  • ATS: 16-16-2
  • O/U: 14-20
  • PPG: 74.2
  • OPPG: 56.9

4) Duke Blue Devils
(ACC, At-Large)

  • Futures: +3900
  • Region: +750
  • SU: 24-8
  • ATS: 18-14
  • O/U: 13-19
  • PPG: 80.2
  • OPPG: 67.2

March Madness Betting Resources

March Madness Sweet 16 Odds

The Sweet 16 of the NCAA Men's Tournament gets underway on Thursday, March 28 and Friday, March 29.

Check out the teams, odds, betting stats and much more on each of the four regions below: