2025 College Football Week 13 Odds: Lines, Spreads, Betting Trends on Biggest Games

Patrick Everson Sports Betting Expert

3 minute read

The College Football Week 13 odds market features an odds mix of games, with nothing resembling a marquee matchup.

Still, there are contests with potential CFP ramifications in the college football odds Week 13 market. Among them: USC vs. Oregon, Pitt vs. Georgia Tech and Missouri vs. Oklahoma.

Here’s everything you need to know about college football odds Week 13: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 13 college football odds and action.

Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: James Lang/Imagn Images)

2025 College Football Odds for Week 13

Missouri vs. Oklahoma Odds

• Opening point spread: Oklahoma -10
• Opening moneyline: Oklahoma TBA/Missouri TBA
• Opening total: Over/Under 44.5 points scored
• Time: Noon ET Saturday (ABC)

OPENING ODDS UPDATE: Oklahoma (8-2 SU/6-4 ATS) faced an absolute must win in Week 12, and absolutely won. The Sooners' defense turned up the heat on Alabama, forcing three turnovers, and OU hung on for a 23-21 victory catching 6.5 points on the road.

Missouri (7-3 SU/6-4 ATS) is likely just looking to play SEC spoiler at this point. In Week 12, the Tigers thumped Mississippi State 49-27 laying 7.5 points at home.

Circa Sports' opening numbers are well-respected and often generate sharp action right out of the gate. Circa opened Oklahoma -10 and dipped to -9.5 within minutes Sunday in college football Week 13 odds. The total was a bigger mover, falling from 44.5 to 42.5 in a hurry.

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USC vs. Oregon Odds

• Opening point spread: Oregon -8
• Opening moneyline: Oregon TBA/USC TBA
• Opening total: Over/Under 58.5 points scored
• Time: 3:30 p.m. ET Saturday (CBS)

OPENING ODDS UPDATE: Oregon (9-1 SU/5-4-1 ATS) easily stayed on track for a College Football Playoff bid in Week 12. The Ducks drilled Minnesota 42-13 laying 26.5 points at home.

Southern Cal (8-2 SU/5-5 ATS) dug itself into first-half holes of 14-0 and 21-7 vs. Iowa. But the Trojans scored the final 20 points of the game in a 26-21 victory giving 6.5 points at home.

USC probably won't reach the Big Ten title game nor the CFP, but can make things messy for the Ducks.

Circa opened Oregon as 8-point home chalk in the college football odds Week 13 market. In very short order Sunday, the Ducks advanced to -9.5

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Pittsburgh vs. Georgia Tech Odds

• Opening point spread: Georgia Tech -2.5
• Opening moneyline: Georgia Tech TBA/Pitt TBA
• Opening total: Over/Under 62.5 points scored
• Time: 7 p.m. ET Saturday (ESPN)

OPENING ODDS UPDATE: Georgia Tech (9-1 SU/6-4 ATS) nearly suffered its second straight loss, and this time to a team that was 1-9 SU. But the Yellow Jackets escaped Boston College with a 36-34 victory, winning on a waning-seconds field goal.

Georgia Tech fell well short of cashing as 16.5-point road chalk, yet remained atop the ACC standings in its quest for a CFP bid.

Pittsburgh (7-3 SU and ATS) got punished in Week 12, but it wasn't an ACC game, so Pitt remains in the conference title hunt, as well. The Panthers were 13-point home underdogs to Notre Dame and tumbled 37-15.

Pitt-Georgia Tech opened at Yellow Jackets -2.5 in Circa's Week 13 college football odds. There's been no early movement Sunday.

BYU vs. Cincinnati Odds

• Opening point spread: BYU -2
• Opening moneyline: BYU TBA/Cincinnati TBA
• Opening total: Over/Under 52.5 points scored
• Time: 8 p.m. ET Saturday (FOX)

OPENING ODDS UPDATE: BYU (9-1 SU/7-3 ATS) rebounded just fine from its blowout loss at Texas Tech. The Cougars were 3-point home favorites and trucked TCU 44-13, staying in the hunt for the Big 12 title and a possible CFP bid.

Cincinnati (7-3 SU/6-4 ATS) saw its Big 12 title hopes take on serious water in Week 12. The Bearcats tumbled to Arizona 30-24 as 5.5-point home favorites, their second straight setback, following a road loss vs. Utah.

Circa Sports opened BYU -2 in the college football Week 13 odds market. The first move came within minutes to Cougars -2.5.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson