2022 Ohio State Buckeyes Betting Odds, Picks & Predictions


It was an unusual season for the Buckeyes in 2021, as it suffered two losses in the regular season, including one against rival Michigan in 'The Big House' to deny Ohio State a trip to the Big Ten Championship Game and a potential College Football Playoff berth.

The Buckeyes offense was prolific for most of the season, going for 41 or more points in nine occasions, including 48 points in a Rose Bowl victory over Utah. Ohio State led the nation in the regular season with 551.6 total yards per game and 45.5 PPG, while ranking fourth with 364.9 passing yards per contest. If there is room for improvement, it is in the run game, where Ohio State 'just' had 186.7 yards per game on the ground.

Defensively, Ohio State needs to get better. It allowed 366.6 total yards per game to rank 52nd in the country, while allowing 246.9 passing yards per outing. Of course, many times the passing yards some opponents were putting up were when the game was out of hand and teams were passing frequently because the run game was off the table.

QB C.J. Stroud shook off an early-season challenge from QB Kyle McCord, and he is a bona fide Heisman Trophy candidate heading into the 2022 campaign. Stroud completed 70.9% of his passes for 3,862 yards, 38 touchdowns and five interceptions. He is NOT a dual-threat option, and a pure pocket passer, running just 31 times with no touchdowns on the ground.

Stroud will also have the hopes of Buckeye Nation on his shoulders, as Alabama's Bryce Young passed his way to a Heisman last season, and he is back in 2022. Mr. Buckeye, Archie Griffin, is the only two-time winner of the Heisman, and Stroud can not only win the trophy and bring it back to Columbus, but he can maintain Ohio State's uniqueness as the only school to have a two-time winner.

Updated on 02/26/2024
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If he is to do so, Stroud will be without WRs Chris Olave and Garrett Wilson, as each were high-round picks in the NFL. WR Jaxon Smith-Njigba (80-1,259-6) led the team in receiving yardage in the regular season, and he exploded for 15 grabs, 347 yards and three scores in the Rose Bowl win over Utah. His 95 total grabs and 1,606 receiving yards to set school records. WR Marvin Harrison Jr., son of the former Indianapolis Colt and NFL Hall of Famer, showed he is more than capable with three scores in the Rose Bowl win.

RB TreyVon Henderson was outstanding with 7.0 yards per rushing attempt, gobbling up 1,165 yards and 15 scores. The run game could be leaned upon a little more with the Buckeyes reloading at receiver.

The defense needs to be much, much better if this team is going to get back to the CFP or more. Ohio State allowed 22.8 points per game, which ranked ninth in the Big Ten, and they couldn't get key stops against Michigan, especially against the run. LB Tommy Eichenberg was a tackle machine in the Rose Bowl with 17 stops, and he could be the next great Buckeyes linebacker.

Ohio State opens with a measuring-stick game against Notre Dame, but the rest of the non-conference schedule is a joke. The team gets crossover games against Wisconsin and Iowa at home, and the only big tests in the East will be trips to Michigan State and Penn State. OVER 10.5 wins is a tremendous play, as this team might lose just one, and it could easily go undefeated. However, you have to pay dearly, laying two times your potential return. As such, bet on Stroud to win the Heisman for better value.

Best Bet: C.J. Stroud Heisman Winner (+250)


  • Sat., Sept. 3 - vs. Notre Dame
  • Sat., Sept. 10 - vs. Arkansas State
  • Sat., Sept. 17 - vs. Toledo
  • Sat., Sept. 24 - vs. Wisconsin
  • Sat., Oct. 1 - vs. Rutgers
  • Sat., Oct. 8 - at Michigan State
  • Sat., Oct. 22 - vs. Iowa
  • Sat., Oct. 29 - at Penn State
  • Sat., Nov. 5 - at Northwestern
  • Sat., Nov. 12 - vs. Indiana
  • Sat., Nov. 19 - at Maryland
  • Sat., Nov. 26 - vs. Michigan


  • Over 10.5 (-200)
  • Under 10.5 (+165)



The Buckeyes have a chip on their shoulder after getting knocked down by Oregon in an early-season game, and by rival Michigan in Ann Arbor to snap a lengthy winning streak in the rivalry. Ohio State is among the favorites to win the national championship, and it should roll through the regular season and into Indianapolis, where it will be heavily favored over anybody coming out of the West Division. Eating this kind of chalk isn't a great idea, but it's hard to imagine a scenario, especially with the Michigan game at home, where the Buckeyes aren't marching into the CFP.



The Buckeyes aren't as much of a sure thing when it comes to matching up with SEC schools, although if anybody can hang with the Alabamas and the Georgias of the world, it's The Ohio State University. Stroud is a top-flight quarterback capable of passing his team to a victory against all comers, and for a chance to more than triple up, roll with the Bucks.

QB C.J. Stroud is a good bet to go wire-to-wire for the Heisman Trophy. (Getty Images)


C.J. Stroud (QB) +250

TreVeyon Henderson (RB) +4000

Jaxon Smith-Njigba (WR) +4000

Marvin Harrison (WR) +20000

Julian Fleming (WR) +30000

Stroud is the early favorite to win the Heisman, although he obviously needs to remain healthy. Anything can happen, and someone will emerge from the shadows who wasn't even a consideration in the preseason. But Stroud threw up mind-boggling numbers, he had a giant Rose Bowl, and it appears he is just scratching the surface. Look for Stroud to do big things and at least have a seat in New York City. He is a decent bet to help you more than double up. The others on the list are big-time players, but as Stroud goes, they go. If he isn't producing, they won't be producing.


  • SU: 11-2
  • ATS: 6-6-1
  • O/U: 8-5
  • ATS-Home: 4-4
  • ATS-Road: 2-2-1
  • ATS-Favorite: 6-6-1
  • ATS-Underdog: 0-0