SOUTHERN-MISS Odds: Schedule, Matchups, & Stats
| Date | Opp | Close | Result | ATS/OU |
| Aug 30, 2025 | Mississippi State | +14.5
/ 60.5 | Lost 17-34 | Lost /
Under |
| Sep 6, 2025 | Jackson State | -12.5
/ 52.5 | Won 38-20 | Won /
Over |
| Sep 13, 2025 | Appalachian State | +3
/ 55.5 | Won 38-22 | Won /
Over |
| Sep 20, 2025 | @Louisiana Tech | +3
/ 51.5 | Lost 20-30 | Lost /
Under |
| Sep 27, 2025 | Jacksonville State | -4.5
/ 55.5 | Won 42-25 | Won /
Over |
| Oct 9, 2025 | @Georgia Southern | -3
/ 59.5 | Won 38-35 | Push /
Over |
| Oct 18, 2025 | @Louisiana | -5
/ 54.5 | Won 22-10 | Won /
Under |
| Oct 25, 2025 | Louisiana-Monroe | -14
/ 49.5 | Won 49-21 | Won /
Over |
| Nov 8, 2025 | @Arkansas State | -6.5
/ 54.5 | Won 27-21 | Lost /
Under |
| Nov 15, 2025 | Texas State | -
/ | | 3:30 PM ET |
| Nov 22, 2025 | @South Alabama | -
/ | | 3:30 PM ET |
| Nov 29, 2025 | Troy | -
/ | | 11:00 AM ET |
• 
363 Texas State 3 - 6 
364 Southern Miss 7 - 2 
