USC vs. Indiana Prediction: Indiana Uses CFP to Fuel Win

Dylan Wilkerson Sports Betting Expert

8 minute read

The USC Trojans will take on the Indiana Hoosiers in this week's college football action. Kickoff is set for 3:30 p.m. EST at Memorial Stadium in Bloomington, IN. The game will be broadcast live on CBS. Here's everything you need to know about USC vs. Indiana odds, the latest college football spreads, college football over/unders and more.

USC @ Indiana Betting Odds

• Spread
• Total
• Moneyline

Time	Open	Bet365	BetMGM	DraftKings	Caesars	FanDuel	Fanatics	Kalshi	Consensus
	Open	›	›	›	›	›	›	›
207 USC	+10.5 -110	+8.5 -110	+8.5 -110	+8.5 -110	+8.5 -108	+8.5 -110	+8.5 -110	+7.5 +104	+8.5 -110
208 Indiana	-10.5 -110	-8.5 -110	-8.5 -108	-8.5 -110	-8.5 -113	-8.5 -110	-8.5 -110	-7.5 -113	-8.5 -110
Matchup
	Open	›	›	›	›	›	›	›
207 USC	o58.5 -112	o50.5 -110	o50.5 -108	o50.5 -108	o50.5 -109	o50.5 -110	o50.5 -110	o50.5 -100	o50.5 -108
208 Indiana	u58.5 -108	u50.5 -110	u50.5 -110	u50.5 -112	u50.5 -112	u50.5 -110	u50.5 -110	u50.5 -104	u50.5 -112
Matchup
	Open	›	›	›	›	›	›	›
207 USC	+320	+270	+270	+270	+275	+260	+260	+285	+270
208 Indiana	-410	-340	-325	-340	-345	-320	-330	-300	-340
Matchup

The Indiana Hoosiers opened as a -10.5 point favorite over USC. The total is set at over/under 50.5 total points scored by both teams combined.

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Updated on 11/12/26

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USC vs. Indiana Prediction

Indiana's offense gets a bad rap, but they do rank 32nd in passing success rate and 16th in EPA per pass attempt. They will also be facing off against a pass defense that ranks 110th in EPA per pass attempt allowed and 100th in overall defensive success rate.

There is no need to question this Indiana defense, which has been a strong point of the team this season. Indiana should take care of USC and jump right back up in the College Football Playoff rankings.

UCS vs. Indiana Prediction: Indiana Hoosiers -8.5 (-110)

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson