NFL Odds Week 10: Lines, Spreads, Betting Trends For All 14 Games

Patrick Everson Sports Betting Expert

11 minute read

2025 NFL Odds Week 10

NFL odds for Week 10, much like Week 9, have a no-doubt marquee matchup, this time among two of the NFC's best.

Philadelphia Eagles vs. Green Bay Packers highlights NFL Week 10 odds, on Monday Night Football. Other notable contests: Los Angeles Rams vs. San Francisco 49ers and New England Patriots vs. Tampa Bay Buccaneers.

Here’s everything you need to know about the NFL odds Week 10 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on Week 10 NFL odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Gregory Fisher/Imagn Images)

NFL Odds for Every Game of NFL Week 10

Las Vegas Raiders vs. Denver Broncos Odds

• Opening point spread: Broncos -10
• Opening moneyline: Broncos TBA/Raiders TBA
• Opening total: Over/Under 42.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

OPENING ODDS UPDATE: Denver (7-2 SU/4-5 ATS) didn't post the most riveting win in Week 9, but you can't argue much with a team on a 6-0 SU streak. The Broncos were 2-point underdogs at Houston and won 18-15 on a final-seconds field goal.

Denver benefited from Houston QB C.J. Stroud exiting with a concussion in the second quarter.

Las Vegas (2-6 SU/3-5 ATS) has dropped six of its last seven games (2-5 ATS). In Week 9, the Raiders got a touchdown with 1:52 remaining to take a 23-20 lead over Jacksonville. But Vegas then gave up a field goal and got pushed to overtime tied at 23.

The Jags then got a TD to go up 30-23, and the Raiders responded with their own TD with just 16 seconds left in OT. But Pete Carroll's troops went for 2 and the win, and didn't get it, losing 30-29 while covering as a 1.5-point home 'dog.

The Raiders-Broncos line made a relatively quick move Sunday night in The SuperBook's NFL odds Week 10 market.

"We took some respected action on the Raiders +10 that bumped us down to +9.5," SuperBook risk manager Casey Degnon said. "I think the spread will see some good two-way action.

"But ultimately, between parlays and teasers, I expect that we will be rooting for the Raiders to pull the upset on TNF."

Atlanta Falcons vs. Indianapolis Colts Odds

• Opening point spread: Colts -6.5
• Opening moneyline: Colts TBA/Falcons TBA
• Opening total: Over/Under 48.5 points scored
• Time: 9:30 a.m. ET Sunday (NFL Network)

OPENING ODDS UPDATE: Indianapolis (7-2 SU/6-3 ATS) finally got knocked off its perch as the NFL team with the best record. Daniel Jones threw three interceptions, and the Steelers tumbled 27-20 giving 3 points at Pittsburgh.

Atlanta (3-5 SU and ATS) gave streaking New England all it could handle in Week 9. Drake London got his third touchdown catch of the day to pull Atlanta within 24-23 with 4:40 remaining. But the Falcons missed the extra point, losing by that same score as 5.5-point road 'dogs.

Falcons-Colts has both teams making the long flight to Berlin, Germany, for a neutral-site game. Indy opened -6.5 in The SuperBook's NFL Week 10 odds.

"Last week, we saw some sharp money on the lookahead line Falcons +7," SuperBook risk manager Casey Degnon said. "We opened 6.5 today, and I don't think the line will go back up.

"But once again, counting parlays and teasers, we will almost certainly be rooting for the Falcons to pull off the upset in Germany."

New England Patriots vs. Tampa Bay Buccaneers Odds

• Opening point spread: Buccaneers -2.5
• Opening moneyline: Buccaneers TBA/Patriots TBA
• Opening total: Over/Under 48.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: New England (7-2 SU/6-3 ATS) barely got off the hook in Week 9, while running its SU win streak to six. The Patriots closed as 5.5-point home favorites and edged Atlanta 24-23.

The winning margin came on a missed extra point after the Falcons got a TD with 4:40 remaining.

Tampa Bay (6-2 SU/5-3 ATS) is coming off its bye week. In Week 8, the Buccaneers dumped New Orleans 23-3 laying 3.5 points on the road.

The SuperBook opened Pats-Bucs at Tampa -2.5 in Week 10 NFL odds, with no movement in the early going.

"This is a sneaky good game in the early slate on Sunday," SuperBook risk manager Casey Degnon said. "I think the public will be split on this one, and I expect both sides will take money throughout the week.

"With the Bucs' high-powered offense and Drake Maye playing like a franchise QB, I think we'll need the Under here."  

Buffalo Bills vs. Miami Dolphins Odds

• Opening point spread: Bills -9.5
• Opening moneyline: Bills TBA/Dolphins TBA
• Opening total: Over/Under 49.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Buffalo (6-2 SU/4-4 ATS) closed as a rare home underdog in Week 9, getting 2.5 points vs. Kansas City. But the Bills notched an impressive 28-21 victory over their AFC archrival. Josh Allen & Co. are on a modest two-game SU and ATS upswing.

Miami (2-7 SU/4-5 ATS) gets a mini-bye, having played in the Week 9 Thursday night game. But it wasn't a good outing for the struggling Dolphins, who lost 28-6 catching 7.5 points at home.

The SuperBook opened Bills-Dolphins at Buffalo -9.5, with no early movement Sunday night. These two teams met in the Week 3 Thursday night game and were tied at 21 early in the fourth quarter.

Buffalo then pulled away for a 31-21 win, but Miami covered as an 11.5-point road 'dog.

New York Giants vs. Chicago Bears Odds

• Opening point spread: Bears -3.5
• Opening moneyline: Bears TBA/Giants TBA
• Opening total: Over/Under 48.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Chicago (5-3 SU and ATS) blew a big late lead at Cincinnati, but still escaped with a Week 9 victory. The Bears led 41-27 with 4:53 remaining, then gave up two TDs to fall behind 42-41 with 54 seconds left.

But Caleb Williams hit Colston Loveland on a 58-yard catch-and-run touchdown to give Chicago a whirlwind 47-42 victory as 3-point road chalk.

New York (2-7 SU/4-5 ATS) got an early TD to go up 7-0, but wouldn't lead again against visiting San Francisco. The Giants gave up 27 of the next 30 points en route to a 34-24 loss getting 2.5 points.

Giants-Bears opened at Chicago -3.5 in The SuperBook's NFL odds Week 10 market. There was no early movement Sunday night.

Baltimore Ravens vs. Minnesota Vikings Odds

• Opening point spread: Ravens -3.5
• Opening moneyline: Ravens TBA/Vikings TBA
• Opening total: Over/Under 47 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Baltimore (3-5 SU and ATS) finally got Lamar Jackson back under center in Week 9, and the result was as expected. The Ravens were 7.5-point Thursday night road favorites and rolled over Miami 28-6.

Minnesota (4-4 SU and ATS) got J.J. McCarthy back under center and evened its record with a big Week 9 upset. The Vikings went to Detroit as 9.5-point pups, led much of the game and held on for a 27-24 victory. Minnesota ended a 1-3 SU and ATS skid.

Baltimore opened -3.5 vs. Minnesota in The SuperBook's NFL Week 10 odds. There was no early movement Sunday night.

Jacksonville Jaguars vs. Houston Texans Odds

• Opening point spread: Texans -1
• Opening moneyline: Texans TBA/Jaguars TBA
• Opening total: Over/Under 39.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Houston (3-5 SU and ATS) looked solid in Week 8 against San Francisco, then regressed in Week 9 as 2-point home chalk vs. Denver. Part of that was due to losing quarterback C.J. Stroud to a concussion in the second quarter.

The Texans put up just five field goals – no touchdowns – and lost 18-15 on a final-seconds field goal.

Jacksonville (5-3 SU and ATS) came out on top in a back-and-forth battle with Las Vegas. The Jaguars got a late field goal to forge a 23-23 tie and force overtime.

In the extra frame, the Jags got a touchdown to go up 30-23, then gave up a TD with just 16 seconds left. But Jacksonville turned back a 2-point attempt to seal a 30-29 victory as 1.5-point road favorites.

Jags-Texans is practically a coin toss, with Houston opening -1 in The SuperBook's Week 10 NFL odds. The spread was stable Sunday night, while the total dropped from 39.5 to 38.5.

Cleveland Browns vs. New York Jets Odds

• Opening point spread: Jets -2
• Opening moneyline: Jets TBA/Browns TBA
• Opening total: Over/Under 38.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: New York (1-7 SU/3-5 ATS) is coming off a bye, after a big comeback to get its first win of the season. The Jets trailed at Cincinnati 38-24 with 10:21 remaining, but rallied for a 39-38 victory catching 5.5 points.

Cleveland (2-6 SU/3-5 ATS) also had a bye in Week 9. The Browns tumbled at New England 32-13 as 7-point Week 8 underdogs.

Week 10 marks a rare occurrence of the Jets being favored, with The SuperBook opening New York -2. The total was stable Sunday night, and the total dropped from 38.5 to 37.5.

New Orleans Saints vs. Carolina Panthers Odds

• Opening point spread: Panthers -4.5
• Opening moneyline: Panthers TBA/Saints TBA
• Opening total: Over/Under 40.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Carolina (5-4 SU/6-3 ATS) notched the upset of the week with a shocking victory at Green Bay. The Panthers closed as 12.5-point underdogs and bagged a 16-13 victory on Ryan Fitzgerald's 49-yard field goal as time expired.

New Orleans (1-8 SU/2-7 ATS) was a double-digit underdog at the L.A. Rams, and played like it. The Saints got rolled 34-10 getting 14.5 points, their fourth consecutive SU and ATS setback.

The SuperBook opened Carolina -4.5 Sunday night in the NFL odds Week 10 market. There's been no early movement.

Arizona Cardinals vs. Seattle Seahawks Odds

• Opening point spread: Seahawks -6
• Opening moneyline: Seahawks TBA/Cardinals TBA
• Opening total: Over/Under 44 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Seattle (5-2 SU and ATS) is in the middle of its Week 9 assignment right now. The Seahawks are hosting the Commanders on Sunday Night Football.

Arizona (2-5 SU and ATS) still has Week 9 work ahead of it, hosting Dallas on Monday night.

Cards-Seahawks opened at Seattle -6 in The SuperBook's Week 10 NFL odds. Once the Seahawks-Commanders game kicked off, Cards-Seahawks was taken off the board, and it will go back up Monday morning.

Los Angeles Rams vs. San Francisco 49ers Odds

• Opening point spread: Rams -3.5
• Opening moneyline: Rams TBA/49ers TBA
• Opening total: Over/Under 49 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Los Angeles (6-2 SU and ATS) was the biggest favorite of Week 9 and had no trouble covering a big number. The Rams coasted to a 34-10 win over New Orleans laying 14.5 points at home.

San Francisco (6-3 SU and ATS) continues finding ways to win with its depleted lineup. In Week 9, the 49ers spotted the New York Giants an early touchdown. Then Mac Jones & Co. scored 27 of the next 30 points on the way to a 34-24 victory laying 2.5 points on the road.

The SuperBook opened Rams-Niners at L.A. -3.5, with no movement Sunday night in NFL Week 10 odds. The total, however, saw a nudge from 49 to 49.5.

"This is a game where I think the public will line up on the Rams, as well as the Over," SuperBook risk manager Casey Degnon said. "Aside from the spread, the Rams will be a popular moneyline play for parlays.

"So I'd be surprised if we're not rooting for the Niners to not only cover, but also win as a home underdog next week."

It wouldn't be first time that's happened this season. In Week 5, injury-depleted San Fran was an 8-point road pup and upset L.A. 26-23 in overtime.

Detroit Lions vs. Washington Commanders Odds

• Opening point spread: Lions -3.5
• Opening moneyline: Lions TBA/Commanders TBA
• Opening total: Over/Under 51.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Detroit (5-3 SU and ATS) was a huge public darling in Week 9, per usual. But it didn't work out for the betting masses, as the Lions tumbled to Minnesota 27-24 as 9.5-point home favorites.

Still, over the past three years – since the middle of the 2022-23 season – Detroit is 42-14 SU/40-15-1 ATS.

Washington (3-4 SU and ATS) is on the field right now, getting smoked by Seattle in the Sunday nighter.

The SuperBook opened Detroit -3.5 vs. Washington, and the game came off the board once Seahawks-Commanders kicked off. Lions-Commanders will go back up Monday morning.

"I think the Commanders' performance will affect the betting on this one, especially with the Lions getting upset today," SuperBook risk manager Casey Degnon said Sunday night. "If I had to guess, I'd think the underdog and Under will be our preferred side come Sunday afternoon." 

Pittsburgh Steelers vs. Los Angeles Chargers Odds

• Opening point spread: Chargers -3.5
• Opening moneyline: Chargers TBA/Steelers TBA
• Opening total: Over/Under 45.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

OPENING ODDS UPDATE: Los Angeles (6-3 SU/5-4 ATS) got more than it bargained for as a 9.5-point favorite at Tennessee. But the Chargers got out with a 27-20 victory.

Pittsburgh (5-3 SU/4-4 ATS) ended a two-game SU and ATS hiccup with a modest Week 9 upset. The Steelers knocked off red-hot Indianapolis 27-20 catching 3 points at home.

Steelers-Chargers opened at L.A. -3.5 in The SuperBook's NFL odds Week 10 market, then dipped to -3 within 20 minutes Sunday night.

"I think we'll see split action up until kickoff. It doesn't feel like either the spread or total will get overwhelming support from the public," SuperBook risk manager Casey Degnon said. "The Chargers will be used in parlays, but not as much as some of the bigger favorites in the week 10 slate."

Philadelphia Eagles vs. Green Bay Packers Odds

• Opening point spread: Packers -3
• Opening moneyline: Packers TBA/Eagles TBA
• Opening total: Over/Under 44.5 points scored
• Time: 8:15 p.m. ET Monday (ABC/ESPN)

OPENING ODDS UPDATE: Green Bay (5-2-1 SU/3-5 ATS) was seen as almost a sure thing in Week 9 vs. Carolina. The Packers closed as 13-point home favorites, but got stung with a 16-13 outright loss on a final-seconds field goal.

Philadelphia (6-2 SU/5-3 ATS) is coming off its bye week, after winning and cashing in the last two games. In Week 8, the Eagles dispatched the New York Giants 38-20 giving 7.5 points at home.

The SuperBook opened Eagles-Packers at Green Bay -3 and is already down to -2.5 Sunday night.

"This is another game where I think we will see somewhat equal action on the spread," SuperBook risk manager Casey Degnon said. "We might not know who we are rooting for Monday night until we actually kick off.

"Either way, it's good to see that we won't have to depend on a touchdown-plus underdog to win outright in prime time."

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson