NFL Odds Week 2: Lines, Spreads, Betting Trends For All 16 Games

Patrick Everson Sports Betting Expert

11 minute read

2025 NFL Odds Week 2

NFL odds for Week 2 show the league wasted little time in creating a Super Bowl rematch.

Philadelphia Eagles vs. Kansas City Chiefs highlights odds for NFL Week 2. And the week kicks off with an intriguing Thursday night battle: Washington Commanders vs. Green Bay Packers.

Here’s everything you need to know about the NFL odds Week 2 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on NFL Week 2 odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Wm. Glasheen/Imagn Images)

NFL Odds for Every Game of NFL Week 2

Washington Commanders vs. Green Bay Packers Odds

• Opening point spread: Packers -3.5
• Opening moneyline: Packers TBA/Commanders TBA
• Opening total: Over/Under 47.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

OPENING ODDS UPDATE: Green Bay (1-0 SU and ATS) got a quick leg up in the NFC North in Week 1. The Packers were in control throughout against Detroit, winning 27-13 as 1.5-point home favorites. The Pack didn't allow a touchdown until the final minute.

Washington (1-0 SU and ATS) had no problem dispatching the New York Giants 21-6. The Commanders allowed only a pair of field goals, in the second and third quarters, and cashed as 6-point home favorites.

John Murray, vice president at The SuperBook, said his risk room was impressed with Green Bay.

"The lookahead number last week was Packers -3. But we opened Green Bay -3.5," Murray said Sunday night, noting the Packers were already drawing money last week at -3. "After they thumped the Lions today, you have to think the public will likely be on them Thursday night.

"It's a very good Thursday night game this week."

The total is stable at 47.5.

Chicago Bears vs. Detroit Lions Odds

• Opening point spread: Lions -4.5
• Opening moneyline: Lions TBA/Bears TBA
• Opening total: Over/Under 47.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Detroit (0-1 SU and ATS) has been a spread-covering machine the last 2.5 seasons, at 35-12-1 ATS heading into Week 1. But the Lions couldn't solve Green Bay, losing 27-13 as 1.5-point road underdogs. Detroit didn't get a touchdown until the final minute.

Chicago still has Week 1 work to do, hosting Minnesota in the Monday night game. But that didn't stop The SuperBook from posting a line in its NFL odds Week 2 market.

"We took some lookahead money last week on the Bears at +5.5. After the Lions looked all out of sorts this afternoon, we re-opened the game at Lions -4.5. Not much to report on it yet," SuperBook vice president John Murray said.

Likewise, the total is steady at 47.5.

Buffalo Bills vs. New York Jets Odds

• Opening point spread: Bills -7.5
• Opening moneyline: Bills TBA/Jets TBA
• Opening total: Over/Under 44.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Buffalo made an absolutely jaw-dropping comeback in the first Sunday night game of the season. The Bills trailed Baltimore 40-25 with under five minutes remaining, but rallied for a stunning 41-40 victory as 1.5-point home underdogs.

Matt Prater, subbing for the injured Tyler Bass, secured the win on a 32-yard field goal as time expired.

New York (0-1 SU/1-0 ATS) hung with Pittsburgh all day, taking a 26-17 lead on a late-third-quarter TD. But the Jets couldn't make it hold up, losing 34-32 on a final-seconds 60-yard field goal. On the bright side, New York covered as a 3-point home pup.

Bills-Jets opened at Buffalo -7.5 in The SuperBook's NFL Week 2 odds, with a total of 44.5. The total nudged to 45 shortly thereafter Sunday night. The matchup was then taken off the board once Ravens-Bills kicked off. Bills-Jets will go back up Monday morning.

Cleveland Browns vs. Baltimore Ravens Odds

• Opening point spread: Ravens -12.5
• Opening moneyline: Ravens TBA/Browns TBA
• Opening total: Over/Under 44.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Baltimore was running up and down the field all Sunday night at Buffalo, leading 40-25 with under five minutes left. But the Ravens stunningly let the Bills come back, in part due to a Derrick Henry fumble, as Baltimore lost 41-40 on a final-seconds field goal.

The Ravens (0-1 SU and ATS) drew sharp money at books across the country, and the public was on Baltimore, as well. But Lamar Jackson & Co. fell and failed to cover as 1.5-point favorites.

Cleveland (0-1 SU/1-0 ATS) closed as 4.5-point home 'dogs vs. Cincinnati, yet led 16-14 midway through the third quarter. Joe Flacco hit Cedric Tillman on a 5-yard TD pass to put the Browns ahead.

But Cleveland gave up a late-third-quarter field goal and lost 17-16, with neither team scoring in the fourth quarter.

Baltimore opened -12.5 vs. Cleveland, with a total of 44.5. The game then came off the board once Ravens-Bills kicked off Sunday night. Ravens-Browns will go back up Monday morning.

Jacksonville Jaguars vs. Cincinnati Bengals Odds

• Opening point spread: Bengals -4.5
• Opening moneyline: Bengals TBA/Jaguars TBA
• Opening total: Over/Under 49.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Cincinnati (1-0 SU/0-1 ATS) was lucky to escape Week 1 with a victory. The Bengals didn't get much offense, but it was enough to edge Cleveland 17-16 as 4.5-point road favorites. Neither team scored in the fourth quarter.

Jacksonville (1-0 SU and ATS) got its 2025 campaign off to a satisfactory start. The Jaguars built a 20-0 halftime lead vs. Carolina and coasted to a 26-10 victory laying 4.5 points at home.

Bengals-Jags opened at Cincy -4.5 in The SuperBook's NFL Week 2 odds. The line was quickly on the move, dipping to Bengals -3.5 Sunday night. The total is stable at 49.5.

Seattle Seahawks vs. Pittsburgh Steelers Odds

• Opening point spread: Steelers -2.5
• Opening moneyline: Steelers TBA/Seahawks TBA
• Opening total: Over/Under 40.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Pittsburgh (1-0 SU/0-1 ATS) eked out a 34-32 victory over the New York Jets. The Steelers closed as 3-point road favorites and needed a 60-yard field goal with 2:10 remaining to get the win.

Seattle (0-1 SU and ATS) and San Francisco were in a low-scoring dogfight throughout their Week 1 clash. But the Seahawks gave up a TD with 1:34 left and lost 17-13 as 2.5-point home underdogs.

Pittsburgh opened as 2.5-point home chalk vs. Seattle in The SuperBook's NFL odds Week 2 market. The Steelers then moved out to -3, while the total was steady at 40.5.

New York Giants vs. Dallas Cowboys Odds

• Opening point spread: Cowboys -4.5
• Opening moneyline: Cowboys TBA/Giants TBA
• Opening total: Over/Under 44.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Dallas (0-1 SU/1-0 ATS) gave defending Super Bowl champion Philadelphia all it could handle in the Week 1 Thursday night game. The Cowboys came up short 24-20, but cashed as 8-point road underdogs.

New York (0-1 SU and ATS) couldn't get its offense on track under new QB Russell Wilson. The Giants netted just two field goals in a 21-6 loss to Washington catching 6 points on the road.

The SuperBook opened Dallas -4.5 in Week 2 NFL odds, with no movement Sunday night. And the total was stable, too, at 44.5.

Los Angeles Rams vs. Tennessee Titans Odds

• Opening point spread: Rams -5.5
• Opening moneyline: Rams TBA/Titans TBA
• Opening total: Over/Under 42.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Los Angeles (1-0 SU and ATS) had a lackluster Week 1 showing. But Houston was even more lackluster. The Rams won a 14-9 snoozer laying 3 points at home.

Tennessee (0-1 SU and ATS) put the fear of God into Circa Survivor entrants and others in Survivor pools across the nation. The Titans were 8.5-point pups at Denver and trailed just 13-12 midway through the fourth quarter. But Tennessee then gave up a TD and lost 20-12.

L.A. opened as a 5.5-point favorite vs. Tennessee, with no movement Sunday night.

New England Patriots vs. Miami Dolphins Odds

• Opening point spread: Dolphins -2
• Opening moneyline: Dolphins TBA/Patriots TBA
• Opening total: Over/Under 44.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Miami (0-1 SU and ATS) flopped in a big way in Week 1. Tua Tagovailoa threw two interceptions, and the Dolphins got drilled 33-8 getting 1 point at Indianapolis.

New England (0-1 SU and ATS) held a 10-7 lead at halftime vs. Las Vegas. But the Patriots managed only a field goal in the second half, losing 20-13 as 2.5-point home favorites.

Miami opened and remains -2 at The SuperBook, and the total hasn't moved off 44.5.

San Francisco 49ers vs. New Orleans Saints

• Opening point spread: 49ers -7
• Opening moneyline: 49ers TBA/Saints TBA
• Opening total: Over/Under 43 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: San Francisco (1-0 SU and ATS) scratched out a 17-13 win over Seattle in Week 1. The Niners got a touchdown with 1:34 remaining to clinch the win and cash as 2.5-point road faves.

New Orleans (0-1 SU and ATS) lost to Arizona 20-13 as 5.5-point home underdogs. That result was widely expected, with the Saints running out second-year QB Spencer Rattler as the starter. But Rattler fared OK, throwing for 214 yards, with no interceptions.

The SuperBook opened the 49ers -7 Sunday night, and that number fell to -6 in short order. The total also moved, from 43 to 43.5.

Denver Broncos vs. Indianapolis Colts Odds

• Opening point spread: Broncos -3
• Opening moneyline: Broncos TBA/Colts TBA
• Opening total: Over/Under 43.5 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Denver (1-0 SU/0-1 ATS) was widely expected to roll as an 8.5-point favorite vs. Tennessee. But the Broncos needed a late TD to put the game away in a 20-12 home victory.

Indianapolis (1-0 SU and ATS) was much more convincing in Week 1. The Colts hammered Miami 33-8 laying 1.5 points at home.

Broncos-Colts opened at Denver -3 and is down to -2.5 in The SuperBook's Week 2 NFL odds. The total hasn't moved off 43.5.

Carolina Panthers vs. Arizona Cardinals Odds

• Opening point spread: Cardinals -7
• Opening moneyline: Cardinals TBA/Panthers TBA
• Opening total: Over/Under 45.5 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Arizona (1-0 SU and ATS) didn't light it up in Week 1 vs. a New Orleans squad expected to be the worst in the NFL. But the Cards got out of town with a 20-13 road win laying 5.5 points.

Carolina (0-1 SU and ATS) couldn't find the end zone until late in the fourth quarter against Jacksonville. As such, the Jags lost 26-10 catching 4.5 points on the road.

Arizona opened -6.5 at The SuperBook and is already up to -7 Sunday night.

Philadelphia Eagles vs. Kansas City Chiefs Odds

• Opening point spread: Eagles -1
• Opening moneyline: Chiefs TBA/Eagles TBA
• Opening total: Over/Under 45.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Philadelphia (1-0 SU/0-1 ATS) was a solid 8-point home favorite vs. Dallas, in the Thursday kickoff to the regular season. But the Eagles had their hands full all night, ultimately prevailing 24-20 while failing to cover.

Kansas City (0-1 SU and ATS), the three-time defending AFC champion, saw its 2025-26 campaign get off to a bumpy start. The Chiefs fell to the L.A. Chargers 24-20, with K.C. 3-point chalk on neutral turf in Sao Paulo, Brazil on Friday.

"The Chiefs were a small favorite on the lookahead number last week. But we opened Philly -1 after seeing Kansas City struggle on Friday night in Brazil," SuperBook VP John Murray said Sunday night. "I’ll be interested to see how the public plays this game.

"Yes, Kansas City is off a loss, and yes, the Eagles destroyed them back in February. But the Eagles had their own struggles in Week 1 and could easily be 0-1 themselves.

Atlanta Falcons vs. Minnesota Vikings Odds

• Opening point spread: Vikings -4.5
• Opening moneyline: Vikings TBA/Falcons TBA
• Opening total: Over/Under 45.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

OPENING ODDS UPDATE: Atlanta (0-1 SU and ATS) lost its 2025-26 debut in heartbreaking fashion. Younghoe Koo missed a 44-yard field in the waning seconds, and the Falcons fell 23-20 as 1-point home 'dogs.

Minnesota hasn't finished its Week 1 assignment. The Vikings visit Chicago in the Monday night game.

Minnesota opened as 4.5-point home chalk vs. Atlanta in The SuperBook's NFL Week 2 odds. The Vikes then moved out to -5.5 Sunday night.

"Atlanta let one get away today at home. but the Falcons will be getting the Vikings off a short week. It's a good early test for both teams," SuperBook VP John Murray said.

Tampa Bay Buccaneers vs. Houston Texans Odds

• Opening point spread: Texans -2.5
• Opening moneyline: Texans TBA/Buccaneers TBA
• Opening total: Over/Under 44.5 points scored
• Time: 7 p.m. ET Monday (ABC)

OPENING ODDS UPDATE: Houston (0-1 SU and ATS) had little to offer offensively in a 14-9 Week 1 loss to the L.A. Rams. The Texans managed just three field goals, all in the first half, while failing to cash as 3-point road underdogs.

Tampa Bay (1-0 SU and ATS) got a jump-start in defense of its NFC South title. The Bucs scored a touchdown with 59 seconds left and survived the missed extra point to beat Atlanta 23-20 as 1-point road favorites. The Falcons missed a 44-yard field goal in the waning seconds.

"We opened this one Texans -2.5 are now at -1.5, after seeing a little money trickle in on the Bucs," SuperBook VP John Murray said Sunday night. "What a win that was for Baker Mayfield and Tampa today.

"This is a good early Monday Night Football matchup, between two teams that expect to be in the playoffs."

Los Angeles Chargers vs. Las Vegas Raiders Odds

• Opening point spread: Chargers -3
• Opening moneyline: Chargers TBA/Raiders TBA
• Opening total: Over/Under 44.5 points scored
• Time: 10 p.m. ET Monday (ESPN)

OPENING ODDS UPDATE: Los Angeles (1-0 SU and ATS) kicked off its season in good form in a neutral-site game at Sao Paulo, Brazil. The Chargers, behind a sterling night from QB Justin Herbert, beat Kansas City 24-20 catching 3 points.

Las Vegas (1-0 SU and ATS) got Pete Carroll's return to coaching off to a good start. The Raiders held off New England 20-13, cashing as 2.5-point road 'dogs.

Los Angeles opened -3 and adjusted to -3 (-120) Sunday night in The SuperBook's NFL odds Week 2 market.

"No action to report yet. Both teams have to be very pleased with their start to the season. It should be a good one here in Las Vegas" SuperBook vice president John Murray said.

In-Progress Games for NFL Week 2

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Completed Games for NFL Week 2

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson