NFL Odds Week 4: Lines, Spreads, Betting Trends For All 16 Games

Patrick Everson Sports Betting Expert

13 minute read

2025 NFL Odds Week 4

NFL odds for Week 4 feature a couple of playoff-worthy matchups. And in the interest of equal time, one is in the AFC, the other in the NFC.

Baltimore Ravens vs. Kansas City Chiefs tops the NFL Week 4 odds board. Philadelphia Eagles vs. Tampa Bay Buccaneers is a big game, as well.

Here’s everything you need to know about the NFL odds Week 4 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on Week 4 NFL odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Peter Casey/Imagn Images)

NFL Odds for Every Game of NFL Week 4

Seattle Seahawks vs. Arizona Cardinals Odds

• Opening point spread: Cardinals -2.5
• Opening moneyline: Cardinals TBA/Seahawks TBA
• Opening total: Over/Under 44.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

OPENING ODDS UPDATE: Arizona (2-1 SU/1-2 ATS) was dealt its first loss on the last play. In a game featuring a dearth of offense, the Cardinals fell to San Francisco 16-15 on a final-seconds field goal, but covered as 1.5-point road 'dogs.

Seattle (2-1 SU and ATS) had no such scoring troubles in Week 3. The Seahawks sprinted to a 38-6 halftime lead vs. New Orleans, then put it in cruise control in a 44-13 win as 7-point home home favorites.

Among Seattle's scores in a huge first half: A 95-yard Tory Horton punt return in the first quarter.

The Seahawks-Cards line was on the move early in The SuperBook's NFL odds Week 4 market.

"We opened this one Cardinals -2.5 and were bet down to -1.5 quickly," SuperBook vice president John Murray said Sunday night. "We don’t want to overreact to the Seahawks' win today too much, given the quality of their opponent.

"The Cardinals have played a very easy schedule so far, which makes them hard to judge."

The total nudged down from 44.5 to 44 Sunday night.

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Minnesota Vikings vs. Pittsburgh Steelers Odds

• Opening point spread: Vikings -1
• Opening moneyline: Steelers TBA/Vikings TBA
• Opening total: Over/Under 41.5 points scored
• Time: 9:30 a.m. ET Sunday (NFL Network)

OPENING ODDS UPDATE: No J.J. McCarthy, no problem for Minnesota (2-1 SU). Behind Carson Wentz, the Vikings steamrolled a Joe Burrow-less Cincinnati 48-10 laying 3 points at home.

Pittsburgh (2-1 SU/1-2 ATS) got its first spread cover of the season. The Steelers closed as 1-point road favorites and beat New England 21-14. A 17-yard Aaron Rodgers-to-Calvin Austin III touchdown pass sealed the win, with 2:16 remaining.

Vikings-Steelers is a neutral-site game at Croke Park in Dublin, Ireland. The SuperBook opened Minnesota -1 and went to -1.5 Sunday night in NFL Week 4 odds.

Philadelphia Eagles vs. Tampa Bay Buccaneers Odds

• Opening point spread: Eagles -3
• Opening moneyline: Eagles TBA/Buccaneers TBA
• Opening total: Over/Under 46 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Philadelphia (3-0 SU/2-1 ATS) found itself getting drilled by the L.A. Rams 26-7 early in the third quarter. Even after rallying to pull ahead 27-26, it looked as if the Eagles would lose on a final-seconds 36-yard L.A. field goal.

But Jordan Davis blocked the kick, scooped it up and ran 61 yards for a touchdown. Stunningly, the Eagles won 33-26 and cashed as 3.5-point home favorites.

Similarly, Tampa Bay (3-0 SU/2-1 ATS) had a field goal blocked and returned for a touchdown by the New York Jets. That put the Bucs behind 27-26 with 1:49 remaining. However, Baker Mayfield led Tampa to a final-seconds field goal and a 29-27 win.

The Buccaneers failed to cover as 6.5-point home favorites.

On Sunday night, The SuperBook opened Eagles-Bucs at Philly -3, with no early movement in Week 4 NFL odds.

"We took sharp money on Eagles -2.5 on the lookahead line last week, and re-opened this game -3 tonight," SuperBook VP John Murray said. "No takers so far. But I would certainly expect us to need the Bucs next week."

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Washington Commanders vs. Atlanta Falcons Odds

• Opening point spread: Commanders -3
• Opening moneyline: Commanders TBA/Falcons TBA
• Opening total: Over/Under 46 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Washington (2-1 SU and ATS) didn't have Jayden Daniels today. But Marcus Mariota steered the ship just fine, and the Commanders beat Las Vegas 41-24 giving 3 points at home.

Mariota got some help from a Jeremy McNichols 60-yard touchdown run and a Jaylin Lane 90-yard punt return for a TD.

Atlanta (1-2 SU and ATS) was dealt one of the more surpising L's of Week 3. The Falcons closed as 4.5-point faves at Carolina and got waxed 30-0.

The big question hovering over Commanders-Falcons is whether Daniels (knee) starts at Atlanta.

"We're shading this line toward Daniels starting at QB for Washington. We opened it Washington -2.5," SuperBook vice president John Murray said. "This game is probably closer to pick if Daniels is out or Washington -3 if he’s in. Obviously, we will be monitoring his status all week."

The total went from 46 to 45.5 Sunday night.

Los Angeles Chargers vs. New York Giants Odds

• Opening point spread: Chargers -5.5
• Opening moneyline: Chargers TBA/Giants TBA
• Opening total: Over/Under 45.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Los Angeles (3-0 SU and ATS) got a stern Week 3 challenge from Denver, but eked out a victory. The Chargers won 23-20 on a final-seconds field goal, narrowly covering as 2.5-point home favorites.

New York (0-3 SU/1-2 ATS) hung with Kansas City in the first half, trailing just 9-6 at the break. But the Giants mustered only a field goal in the second half and blew several opportunities, losing 22-9 as 6-point home 'dogs.

The SuperBook opened Chargers-Giants at L.A. -5.5, with a total of 45.5. Once Chiefs-Giants kicked off Sunday night, Chargers-Giants came off the NFL Week 4 odds board. Chargers-Giants will go back up Monday morning.

New Orleans Saints vs. Buffalo Bills Odds

• Opening point spread: Bills -16.5
• Opening moneyline: Bills TBA/Saints TBA
• Opening total: Over/Under 47.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Buffalo (3-0 SU/2-1 ATS) is rested up, having played in the Week 3 Thursday nighter. In that contest, Buffalo got more from Miami than expected, tied at 21 early in the fourth quarter. The Bills notched a 31-21 victory, but failed to cash as 11.5-point home favorites.

New Orleans (0-3 SU and ATS) was the proverbial one-legged man in a butt-kicking contest Sunday. The Saints trailed Seattle 38-6 at halftime en route to a 44-13 loss catching 7 points at home.

Saints-Bills features the biggest point spread in the NFL odds Week 4 market. In fact, it's the biggest spread of the season so far. Buffalo opened -16.5 at The SuperBook, with a total of 47.5, and both numbers are stable Sunday night.

Cleveland Browns vs. Detroit Lions Odds

• Opening point spread: Lions -8
• Opening moneyline: Lions TBA/Browns TBA
• Opening total: Over/Under 45.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Cleveland (1-2 SU/2-1 ATS) pulled the upset of the week and arguably of the season thus far. The Browns got a 55-yard Andre Szmyt field goal as time expired, shocking Green Bay 13-10 as 7.5-point home underdogs.

Cleveland also did a number on Circa Survivor, knocking out more than 1,800 entries.

Detroit (1-1 SU and ATS) still has a huge Week 3 test ahead. The Lions visit Baltimore on Monday night. Still, The SuperBook went ahead and opened Detroit -8 vs. Cleveland and already advanced to -8.5 Sunday night in Week 4 NFL odds.

Tennessee Titans vs. Houston Texans Odds

• Opening point spread: Texans -7
• Opening moneyline: Texans TBA/Titans TBA
• Opening total: Over/Under 40 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Houston made the playoffs last season, getting a Divisional Round win over the L.A. Chargers before bowing out to Kansas City. Getting back to the postseason will be a chore, with the Texans now 0-3 SU and ATS.

In Week 3, Houston was a 1.5-point road pup and lost to Jacksonville 17-10. The Texans gave up a TD with 1:48 remaining to account for the final margin.

Tennessee (0-3 SU/1-2 ATS) is also seeking its first SU victory. In Week 3, the Titans got drilled by Indianapolis 41-20 getting 6 points at home.

The SuperBook opened Titans-Texans at Houston -7, with no movement as of 10 p.m. ET Sunday night.

Carolina Panthers vs. New England Patriots Odds

• Opening point spread: Patriots -4
• Opening moneyline: Patriots TBA/Panthers TBA
• Opening total: Over/Under 44.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Carolina (1-2 SU/2-1 ATS) entered its Week 3 home game vs. Atlanta as a 4.5-point home underdog. Then the Panthers went out and pounded the Falcons 30-0, giving Carolina its first SU win of the season.

New England (1-2 SU and ATS) rallied from a 14-0 second-quarter deficit, tying Pittsburgh at 14 early in the fourth quarter. But the Patriots gave up a TD with 2:16 remaining and lost 21-14 catching 1 point at home.

The Pats opened -4 vs. the Panthers in The SuperBook's NFL Week 4 odds. An hour later Sunday night, New England advanced to -4.5.

Indianapolis Colts vs. Los Angeles Rams Odds

• Opening point spread: Rams -4
• Opening moneyline: Rams TBA/Colts TBA
• Opening total: Over/Under 47 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Los Angeles (2-0 SU and ATS) was fully in position to get to 3-0, and against the Super Bowl champion no less. The Rams trailed 27-26 at Philadelphia, but were lining up for a game-winning 36-yard field goal.

However, Jordan Davis blocked the kick and returned it 61 yards for a touchdown, dealing the Rams a stunning 33-26 loss as 3.5-point underdogs.

Indianapolis (3-0 SU and ATS) has to be the most surprising unbeaten through three weeks. On Sunday, the Colts closed as 6-point faves at Tennessee and rolled to a 41-20 victory.

The SuperBook opened L.A. as 4-point road chalk and dipped to -3.5 Sunday night. The total is on the move, too, going from 47 to 48 in minutes and settling at 48.5 within 30 minutes.

Jacksonville Jaguars vs. San Francisco 49ers Odds

• Opening point spread: 49ers -4
• Opening moneyline: 49ers TBA/Jaguars TBA
• Opening total: Over/Under 45.5 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: San Francisco (3-0 SU and ATS) was once again without QB Brock Purdy, and once again found a way to win, albeit in ugly fashion. The 49ers got a 35-yard Eddy Pineiro field goal as time expired to beat Arizona 16-15.

However, the Niners didn't cover as 1.5-point home faves.

Jacksonville (2-1 SU and ATS) bounced back from a last-minute Week 2 loss at Cincinnati. Travis Etienne Jr.'s 10-yard TD run with 1:48 left gave the Jaguars a 17-10 win over Houston laying 1.5 points at home.

Jags-Niners opened at San Fran -4 in The SuperBook's NFL odds Week 4 market. Within 30 minutes, the 49ers dipped to -3.5.

Baltimore Ravens vs. Kansas City Chiefs Odds

• Opening point spread: Ravens -3
• Opening moneyline: Ravens TBA/Chiefs TBA
• Opening total: Over/Under 48.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Kansas City (1-2 SU and ATS) took three weeks, but finally notched its first win of the season. It wasn't exactly pretty, but the Chiefs beat the New York Giants 22-9 laying 6 points on the road Sunday night.

Baltimore (1-1 SU and ATS) still has Week 3 work to do, with a big Monday night clash vs. visiting Detroit.

"We opened Baltimore -3, and it quickly came off the board when the Sunday night Chiefs-Giants game kicked off," SuperBook VP John Murray said. "No takers either way. This line really speaks to how highly power-rated Baltimore is.

"Even though the Ravens lost to Buffalo in Week 1, we have them as the best team in the NFL."

Ravens-Bills will go back up Monday morning at The SuperBook.

Chicago Bears vs. Las Vegas Raiders Odds

• Opening point spread: Raiders -2
• Opening moneyline: Raiders TBA/Bears TBA
• Opening total: Over/Under 47.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: In Week 3, Chicago (1-2 SU and ATS) got Ben Johnson his first win as an NFL head coach. And in impressive fashion. The Bears were locked in a 14-14 tie midway through the second quarter, but outscored Dallas 17-0 the rest of the way in a 31-14 win.

Chicago closed as a 1.5-point home underdog.

After a Week 1 win at New England, Las Vegas (1-2 SU and ATS) is on a two-game SU and ATS hiccup. In Week 3, the Raiders didn't have to face Jayden Daniels (knee), but still couldn't keep up with Washington, losing 41-24 as 3-point road pups.

The SuperBook opened Bears-Raiders at Las Vegas -2 and dipped to -1.5 shortly thereafter Sunday night.

Green Bay Packers vs. Dallas Cowboys Odds

• Opening point spread: Packers -6.5
• Opening moneyline: Packers TBA/Cowboys TBA
• Opening total: Over/Under 48.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

OPENING ODDS UPDATE: Green Bay (2-1 SU and ATS) got a bunch of hype after it's 2-0 start, beating Detroit and Washington. But the Packers crashed back to earth in Week 3, losing 13-10 at Cleveland on a final-seconds field goal. The Pack were 7.5-point favorites.

Dallas (1-2 SU and ATS) dug out of an early 14-3 hole at Chicago by tying the game at 14 midway through the second quarter. But the Cowboys didn't score another point, losing 31-14 as 1.5-point road faves.

Just before Week 1, Dallas shipped star linebacker Micah Parsons to Green Bay in a huge trade. Now, Parsons will get a shot at his former team.

The SuperBook made some adjustments from last week to this week on Packers-Cowboys, with a notably higher number in the NFL odds Week 4 market.

"The lookahead number was Packers -4.5. But we re-opened Packers -6.5 after the Dallas loss to Chicago this afternoon," SuperBook VP John Murray said Sunday night. "The Cowboys' secondary has issues. We’ll be big Cowboys fans next Sunday night."

The spread bounced between Pack -6.5/-6 a couple times in the first hour, then settled at -6.

New York Jets vs. Miami Dolphins Odds

• Opening point spread: Dolphins -2.5
• Opening moneyline: Dolphins TBA/Jets TBA
• Opening total: Over/Under 44.5 points scored
• Time: 7:15 p.m. ET Monday (ESPN)

OPENING ODDS UPDATE: Miami (0-3 SU/1-2 ATS) was tied with Buffalo at 21 early in the fourth quarter and was driving for a potential tying touchdown late in the fourth. But Tua Tagovailoa threw an interception, and the Dolphins fell 31-21 as 11.5-point road underdogs.

New York (0-3 SU/1-2 ATS) got a huge play that put it on the brink of a Week 3 win. Will McDonald IV blocked a Tampa field goal and returned it 50 yards for a touchdown, giving the Jets a 27-26 lead with 1:49 remaining.

But Gang Green then let the Bucs drive into position for a final-seconds field goal and lost 29-27 catching 6.5 points.

The SuperBook opened Jets-Dolphins at Miami -2.5 flat, then adjusted to Miami -2.5 (-120) Sunday night.

Cincinnati Bengals vs. Denver Broncos Odds

• Opening point spread: Broncos -7.5
• Opening moneyline: Broncos TBA/Bengals TBA
• Opening total: Over/Under 45 points scored
• Time: 8:15 p.m. ET Monday (ABC)

OPENING ODDS UPDATE: Denver (1-2 SU/0-3 ATS) had a great opportunity to post a mild upset of the L.A. Chargers. The Broncos led 20-13 after a field goal with 12:21 remaining. But Denver gave up a tying TD with 2:37 left, then loss on a last-second field goal 23-20.

Denver, a 2.5-point road 'dog, fell for the second week on a field goal as time expired.

Cincinnati (2-1 SU/1-1 ATS) found the first week without Joe Burrow (toe) not much to its liking. Jake Browning and the Bengals got trucked by Minnesota 48-10 getting 3 points on the road. And that was with the Vikings minus QB J.J. McCarthy, as Carson Wentz led the way.

Bengals-Broncos saw a lot of early movement in The SuperBook's NFL odds Week 4 market. In the first hour Sunday night, Denver went from -7.5 to -8, then dropped to -7 before returning -7.5.

"Two tough losses in a row for the Broncos on field goals as time expires," SuperBook VP John Murray said. "This is a lot to ask of Jake Browning going into Denver on a Monday Night.

"The lookahead line was more like Denver -6. But we felt we needed to adjust after the Bengals' performance today."

The total inched from 45.5 to 45 Sunday night.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson