NFL Odds Week 5: Lines, Spreads, Betting Trends For All 14 Games

Patrick Everson Sports Betting Expert

10 minute read

2025 NFL Odds Week 5

NFL odds for Week 5 feature a few games between teams that reached the postseason last year.

For the fourth straight week, the Philadelphia Eagles face a playoff team, hosting the Denver Broncos. Other interesting contests in NFL Week 5 odds: Houston Texans vs. Baltimore Ravens and Washington Commanders vs. Los Angeles Chargers.

Here’s everything you need to know about the NFL odds Week 5 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on Week 5 NFL odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Bill Streicher/Imagn Images)

NFL Odds for Every Game of NFL Week 5

San Francisco 49ers vs. Los Angeles Rams Odds

• Opening point spread: Rams -3.5
• Opening moneyline: Rams TBA/49ers TBA
• Opening total: Over/Under 47.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

OPENING ODDS UPDATE: Los Angeles (3-1 SU and ATS) rallied for a Week 4 victory, bouncing back from a stunning ending at Philadelphia in Week 3. The Rams trailed 20-13 with 8:58 remaining vs. Jacksonville, then put up two touchdowns for a 27-20 win laying 3.5 points at home.

San Francisco (3-1 SU and ATS) got Brock Purdy back under center, but it wasn't enough to dodge their first loss. The 49ers dug themselves into a 14-3 second-quarter hole and never fully got out of it, losing to Jacksonville 26-21 as 3-point home favorites.

In the NFL Week 5 odds market, The SuperBook opened L.A. -3.5 at 7 p.m. ET Sunday night, with no movement as of 9:15 p.m. ET.

"We took some money on 49ers +3.5/+3 on the lookahead line last week. But we still felt fine with opening this game Rams -3.5, after watching San Francisco today. The public will be on Rams," SuperBook vice president John Murray said.

Minnesota Vikings vs. Cleveland Browns Odds

• Opening point spread: Vikings -4
• Opening moneyline: Vikings TBA/Browns TBA
• Opening total: Over/Under 38 points scored
• Time: 9:30 a.m. ET Sunday (NFL Network)

OPENING ODDS UPDATE: Minnesota (2-2 SU and ATS) rallied from a 24-6 deficit in the fourth quarter, but ran out of time vs. Pittsburgh. The Vikings fell 24-21 as 2.5-point neutral-site favorites in Dublin, Ireland.

Cleveland (1-3 SU/2-2 ATS) upset Green Bay last week, but couldn't repeat against another NFC North standout. The Browns tumbled to Detroit 34-10 getting 10 points on the road.

Minnesota remains in Europe for a second straight week, with the Vikings-Browns game in London. The SuperBook opened the Vikes -4, went to -4.5 for a couple hours and is back at -4 Sunday night. The total is also on the move, from 38 to 37.5/37.

Denver Broncos vs. Philadelphia Eagles Odds

• Opening point spread: Eagles -5.5
• Opening moneyline: Eagles TBA/Broncos TBA
• Opening total: Over/Under 44 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Philadelphia (4-0 SU/3-1 ATS) gave away most of two 18-point leads, 24-6 at halftime and 31-13 late in the third quarter. But the Eagles held on for a 31-25 victory at Tampa Bay, cashing as 3.5-point favorites

Denver (1-2 SU/0-3 ATS) still has Week 4 work to do. The Broncos host Cincinnati on Monday night.

Still, The SuperBook went ahead and opened Philly as 5.5-point home chalk in the NFL odds Week 5 market. There's been no movement Sunday night.

"We haven't seen much on the game yet. But the Eagles will be a popular moneyline and teaser option," SuperBook VP John Murray said. "So I'm pretty sure we’ll be rooting for the Broncos, who will be coming off a short week."

Houston Texans vs. Baltimore Ravens Odds

• Opening point spread: TBA
• Opening moneyline: Ravens TBA/Texans TBA
• Opening total: Over/Under TBA points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Baltimore, a preseason favorite in Super Bowl odds, is now 1-3 SU and ATS facing its third playoff team in four weeks. The Ravens were 2.5-point road favorites vs. Kansas City, but couldn't keep pace in a 37-20 loss.

That wasn't the only big loss. Baltimore QB Lamar Jackson exited with a hamstring injury late in the third quarter and did not return.

It took four weeks, but Houston (1-3 SU and ATS) finally got its first W. The Texans blanked Tennessee 26-0 giving 7.5 points at home.

With Jackson's status unclear, The SuperBook held off putting up a Texans-Ravens number in Week 5 NFL odds. SuperBook VP John Murray noted that last week's lookahead line was Baltimore -10, but that will change significantly if Cooper Rush is the starter.

Dallas Cowboys vs. New York Jets Odds

• Opening point spread: Cowboys -1.5
• Opening moneyline: Cowboys TBA/Jets TBA
• Opening total: Over/Under 46 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Dallas (1-2 SU and ATS) is in the midst of its Week 4 assignment right now. The Cowboys are hosting the Green Bay Packers in Sunday Night Football.

New York (0-3 SU/1-2 ATS) also has Week 4 work remaining, with the Jets at Miami on Monday night.

The SuperBook opened Cowboys-Jets at Dallas -1.5, but the game came off the board once Cowboys-Packers kicked off. Cowboys-Jets will go back up Monday morning.

New York Giants vs. New Orleans Saints Odds

• Opening point spread: Giants -1.5
• Opening moneyline: Giants TBA/Saints TBA
• Opening total: Over/Under 42.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: New York (1-3 SU/2-2 ATS) got the upset of Week 3 behind rookie starting QB Jaxson Dart. The Giants closed as 6-point home underdogs and held on for a 21-18 victory over the Los Angeles Chargers.

New Orleans (0-3 SU/1-3 ATS) was the biggest underdog of the season so far, catching 14.5 points at Buffalo. Yet with 8:53 remaining, after a field goal, the Saints were within 21-19. But that was it for New Orleans in a 31-19 loss, though the Saints covered for the first time this season.

The SuperBook opened Giants-Saints at New York -1.5 in the NFL odds Week 5 market. The Giants are already up a tick to -2 Sunday night.

Las Vegas Raiders vs. Indianapolis Colts Odds

• Opening point spread: Colts -6.5
• Opening moneyline: Colts TBA/Raiders TBA
• Opening total: Over/Under 49.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Indianapolis (3-1 SU and ATS) were in position to stay unbeaten on the field and at the betting window. Trailing the L.A. Rams 13-10, the Colts put up a touchdown and a field goal in the first half of the fourth quarter to go up 20-13.

But Indy gave up two touchdowns in the final minutes and lost 27-20 as 3.5-point road underdogs.

Las Vegas (1-3 SU and ATS) had a potential win on the foot of Daniel Carlson in the final minute vs. Chicago. But the 54-yard field goal was blocked, and the Raiders lost 25-24 as 1.5-point home favorites.

Indianapolis has already toggled from -6.5 to -7 and back to -6.5 on Sunday night in The SuperBook's NFL Week 5 odds. The total went from 49.5 to 49.

Miami Dolphins vs. Carolina Panthers Odds

• Opening point spread: Pick 'em
• Opening moneyline: Panthers TBA/Dolphins TBA
• Opening total: Over/Under 45.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Miami (0-3 SU/1-2 ATS) has Week 4 work remaining, as the Dolphins host the Jets in the opener of a Monday night twinbill.

Carolina (1-3 SU/2-2 ATS) didn't look like the team that blanked Atlanta 30-0 in Week 3. The Panthers, 5.5-point pups at New England took a 6-0 lead, then gave up 42 straight points in a 42-13 loss.

In Week 5 NFL odds, The SuperBook opened this game at pick Sunday night, with no movement so far.

Tampa Bay Buccaneers vs. Seattle Seahawks Odds

• Opening point spread: Seahawks -2.5
• Opening moneyline: Seahawks TBA/Buccaneers TBA
• Opening total: Over/Under 46 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Seattle (3-1 SU and ATS) was in control at Arizona in the Week 3 Thursday nighter, leading 20-6 with 9:33 remaining. Then the Seahawks barely avoided overtime, winning on a last-second field goal 23-20 as 1.5-point favorites.

The Seahawks are on a 3-0 SU and ATS surge since a Week 1 loss to San Francisco.

Tampa Bay (3-1 SU/2-2 ATS) twice found itself in 18-point holes vs. Philadelphia, down 24-6 at halftime and 31-13 late in the third quarter. The Bucs rallied but came up short, losing 31-25 as 3.5-point home underdogs.

For Bucs-Seahawks, The SuperBook saw a little early shove on Seattle in the NFL odds Week 5 market.

"We opened Seattle -2.5 (-110), took money on the Seahawks and moved to -2.5 (-120). I’ll be interested to see how they bet this game from here," SuperBook vice president John Murray said Sunday night.

The total is the bigger mover as of 9:30 p.m. ET Sunday. It opened at 46 and within an hour went to 45.5/45.

Tennessee Titans vs. Arizona Cardinals Odds

• Opening point spread: Cardinals -9.5
• Opening moneyline: Cardinals TBA/Titans TBA
• Opening total: Over/Under 41.5 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Arizona (2-2 SU and ATS) saw a big late fourth-quarter rally come up short at home vs. Seattle. The Cards scored two touchdowns in the final six minutes, erasing a 20-6 deficit Thursday night.

But Arizona, a 1.5-point 'dog, then fell 23-20 on a final-seconds field goal

Tennessee (0-4 SU/1-3 ATS) got zero offense and remained at zero wins. The Titans tumbled 26-0 getting 7.5 points at Houston.

Titans-Cardinals opened at Arizona -9.5 in The SuperBook's NFL odds Week 5 market. There's no movement so far Sunday night. The total, however, is on the move early, from 41.5 to 41/40.5.

Washington Commanders vs. Los Angeles Chargers Odds

• Opening point spread: Chargers -2.5
• Opening moneyline: Chargers TBA/Commanders TBA
• Opening total: Over/Under 48.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Los Angeles (3-1 SU and ATS) was dealt its first setback of the season, and to an unlikely suspect. The Chargers, 6-point road favorites, were down double digits at two junctures and lost to the New York Giants 21-18.

Washington (2-2 SU and ATS) once again didn't have Jayden Daniels (knee), but it didn't work out as well as in Week 3. The Commanders fell to Atlanta 34-27 as 2.5-point road 'dogs.

Los Angeles is a stable 2.5-point home favorite Sunday night in The SuperBook's Week 5 NFL odds.

"No action yet here. We expect Daniels to be back for this one. But I said that last Sunday, too," SuperBook VP John Murray said.

The total opened at 48.5 and nudged to 48.

Detroit Lions vs. Cincinnati Bengals Odds

• Opening point spread: Lions -8.5
• Opening moneyline: Lions TBA/Bengals TBA
• Opening total: Over/Under 49.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Detroit (3-1 SU and ATS) found itself down 7-0 to Cleveland in the first quarter. Then the Lions scored the next 20 points and 34 of the final 37, rolling to a 34-10 victory as 10-point home faves.

Cincinnati (2-1 SU/1-2 ATS) isn't out of Week 4 yet. The Bengals, still without QB Joe Burrow (toe) likely until December, visit Denver on Monday night.

In NFL Week 5 odds, The SuperBook opened and remains at Lions -8.5 Sunday night. The total crept from 49.5 to 49.

New England Patriots vs. Buffalo Bills Odds

• Opening point spread: Bills -9.5
• Opening moneyline: Bills TBA/Patriots TBA
• Opening total: Over/Under 49 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

OPENING ODDS UPDATE: Buffalo (4-0 SU/2-2 ATS) got a much tougher test than expected in Week 4 vs. New Orleans. The Bills led just 21-19 with 8:53 remaining, but closed it out with the final 10 points in a 31-29 victory laying 14.5 points at home.

Not surprisingly, Buffalo was the most-selected team in Circa Survivor Week 4.

New England (2-2 SU and ATS) gave up an early TD to fall behind Carolina 6-0. But the Patriots then punched up the next 42 points en route to a 42-13 win as 5.5-point home favorites.

The SuperBook opened Bills-Pats at Buffalo -9.5 and backed up to -9 within about an hour Sunday night. The total also saw a half-point adjustment, from 49.5 to 49.

Kansas City Chiefs vs. Jacksonville Jaguars Odds

• Opening point spread: Chiefs -3
• Opening moneyline: Chiefs TBA/Jaguars TBA
• Opening total: Over/Under 44.5 points scored
• Time: 8:15 p.m. ET Monday (ABC/ESPN)

OPENING ODDS UPDATE: Kansas City (2-2 SU and ATS) took four weeks, but finally got to .500 on the season. And in impressive fashion. The Chiefs closed as 2.5-point home pups to Baltimore, but rolled to a 37-20 victory.

Jacksonville (3-1 SU and ATS) is off to a better start than most expected. In Week 4, the Jags built a 17-6 halftime lead at San Francisco and held on for a 26-21 victory getting 3 points.

"We saw sharp action on Jacksonville +3.5 on the lookahead line. So we felt comfortable re-opening the game at K.C. -3, even after the Chiefs' impressive win today," SuperBook vice president John Murray said.

There was no Sunday night movement with the spread, but the total went from 44.5 to 45/45.5 in NFL Week 5 odds.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson