NFL Odds Week 6: Lines, Spreads, Betting Trends For All 15 Games

Patrick Everson Sports Betting Expert

13 minute read

2025 NFL Odds Week 6

NFL odds for Week 6 feature a Sunday night showdown perhaps worthy of a Super Bowl.

Detroit Lions vs. Kansas City Chiefs is the marquee matchup in NFL Week 6 odds. And the Los Angeles Rams vs. Baltimore Ravens tilt is a pretty good interconference matchup, as well.

Here’s everything you need to know about the NFL odds Week 6 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on Week 6 NFL odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Kimberly P. Mitchell/Imagn Images)

NFL Odds for Every Game of NFL Week 6

Philadelphia Eagles vs. New York Giants

• Opening point spread: Eagles -7
• Opening moneyline: Eagles TBA/Giants TBA
• Opening total: Over/Under 42.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

OPENING ODDS UPDATE: Philadelphia (4-1 SU/3-2 ATS) somehow took its first loss of the season, despite taking a 17-3 lead into the fourth quarter. The Eagles gave up the final 18 points in a 21-18 loss laying 4 points at home.

New York (1-4 SU/2-3 ATS) got out of the gate quickly in rookie QB Jaxson Dart's second start. But after taking a 14-3 lead early in the second quarter, the Giants didn't score again, losing to New Orleans 26-14 as 2.5-point road underdogs.

Dart had two touchdown passes, both to Theo Johnson, but threw two interceptions, as well. Also, rookie running back Cam Skattebo fumbled in the red zone early in the fourth quarter, and New Orleans ran it back for the game's final score.

At 7 p.m. ET Sunday, The SuperBook opened Eagles-Giants at Philly -7. There's been no movement in the NFL odds Week 6 market, as of 9 p.m. ET Sunday.

"A touchdown favorite in a standalone prime-time game almost guarantees that we'll need the underdog Thursday night," SuperBook risk manager Casey Degnon said. "A million teasers and parlays will no doubt start off with the Eagles as the first leg leading into the weekend."

Denver Broncos vs. New York Jets Odds

• Opening point spread: Broncos -7
• Opening moneyline: Broncos TBA/Jets TBA
• Opening total: Over/Under 43.5 points scored
• Time: 9:30 a.m. ET Sunday (NFL Network)

OPENING ODDS UPDATE: Denver (3-2 SU/2-3 ATS) made a big comeback to notch a nice road upset in Week 5. The Broncos went to Philly as 4-point underdogs and exited with a surprising 21-18 victory.

Bo Nix & Co. trailed 17-3 entering the fourth quarter, but scored the final 18 points of the game.

New York (0-5 SU/1-4 ATS) scored the first three points of the game against Dallas, on a mid-first-quarter field goal. Then the Jets gave up the next 30 points in a 37-22 loss giving 1.5 points at home.

Broncos-Jets is another London game. The SuperBook opened Denver -7 in NFL Week 6 odds, with no movement as of 9 p.m. ET Sunday night.

Los Angeles Rams vs. Baltimore Ravens Odds

• Opening point spread: Rams -7
• Opening moneyline: Rams TBA/Ravens TBA
• Opening total: Over/Under 44.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Baltimore is 1-4 SU and ATS, putting them well behind the 8-ball with less than a third of the season complete. In Week 5, the Ravens – minus Lamar Jackson and a host of others – got blasted by Houston 44-10 as 2.5-point home pups.

Los Angeles (3-2 SU and ATS) was dealt one of the bigger upsets of the season so far, in the Week 4 Thursday nighter. The Rams closed as 8-point home favorites against injury-riddled San Francisco, but lost outright 26-23 in overtime.

That proved to be a hugely costly game for Circa Survivor, knocking out 3,524 entries, nearly 30% of the remaining field.

The SuperBook is working on the assumption that Jackson (hamstring) will miss a third game when the Rams and Ravens line up. Los Angeles opened as 7-point road chalk in Week 6 NFL odds.

"This is another game where I think they'll be lining up to put the Rams in parlays and teasers," SuperBook risk manager Casey Degnon said Sunday night. "The Ravens were a no-show today, so I doubt the public will be looking back them here.

"Regardless of the straight-bet ticket count, I think we'll need Baltimore once that game kicks off."

Seattle Seahawks vs. Jacksonville Jaguars Odds

• Opening point spread: Jaguars -1
• Opening moneyline: Jaguars TBA/Seahawks TBA
• Opening total: Over/Under 45.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Seattle (3-2 SU and ATS) ended up on the short end of a shootout with Tampa Bay. The Seahawks got a touchdown to take a 35-28 lead with 3:18 remaining.

But Seattle then allowed a game-tying TD, Sam Darnold threw an interception, and the Seahawks lost 38-35 on a final-seconds field goal.

Jacksonville (3-1 SU and ATS) is off to a solid start, but still has Week 5 work to complete. The Jaguars host Kansas City on Monday night.

Seahawks-Jags opened Jacksonville -1.5 in The SuperBook's NFL odds Week 6 market.

This is a game that I think will see good two-way action," SuperBook risk manager Casey Degnon said. "We were split on opening this game at pick or Jags -1. I think Chiefs-Jags Monday Night Football will determine who the public bets early on.

"I don't think we'll know who we're rooting for until we kickoff."

Arizona Cardinals vs. Indianapolis Colts Odds

• Opening point spread: Colts -4.5
• Opening moneyline: Colts TBA/Cardinals TBA
• Opening total: Over/Under 47.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Arizona (2-3 SU and ATS) arguably took the most stinging loss of Week 5. The Cardinals blew all of a 21-3 lead and tumbled to the Tennessee Titans 22-21 on a final-seconds field goal.

Arizona led 21-6 entering the fourth quarter, and Emari Demercado broke loose for a 72-yard touchdown run that should've put the Cards up 28-6. But inexplicably, Demercado let go of the ball before crossing the goal line, and it rolled out of bounds in the end zone for a touchback.

Instead of 28-6, it was still 21-6. The Cardinals then allowed two touchdowns and that final field goal to lose.

Indianapolis, behind a revitalized Daniel Jones, is arguably the biggest surprise so far this season at 4-1 SU and ATS. In Week 5, the Colts boat-raced Las Vegas 40-6 laying 7 points at home.

Indy spotted the Raiders a late-first-quarter field goal, then scored the next 40 points. Colts running back Jonathan Taylor had three touchdowns.

The Cards-Colts line is already on the move in The SuperBook's NFL Week 6 odds. Indy opened -4.5 and went to -5.5 within about 30 minutes Sunday night. The total nudged from 47.5 to 47.

Los Angeles Chargers vs. Miami Dolphins Odds

• Opening point spread: Chargers -5.5
• Opening moneyline: Chargers TBA/Dolphins TBA
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Los Angeles (3-2 SU and ATS) got out to a 10-0 first-quarter lead against Washington. But the Chargers didn't put up a single point the rest of the way, losing 27-10 as 3-point home faves.

Similarly, Miami (1-4 SU/2-3 ATS) looked as if it was finally on track in Week 5, getting out to a 17-0 lead at Carolina. But the Dolphins gave it all back in a 27-24 loss as 1.5-point favorites.

Trailing 20-17, Miami got a Jaylen Waddle TD catch with 4:42 remaining to go up 24-20. But the Dolphins gave up a TD with 1:59 remaining and couldn't mount a scoring drive.

The SuperBook opened Chargers-Dolphins at L.A. -5.5 in Week 6 NFL odds, with no movement as of 9:30 p.m. ET Sunday. However, the total is on the move, already down to 45 from a 46.5 opener.

Dallas Cowboys vs. Carolina Panthers Odds

• Opening point spread: Cowboys -3.5
• Opening moneyline: Cowboys TBA/Panthers TBA
• Opening total: Over/Under 49.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Dallas (2-2-1) climbed back to .500 in a Week 5 road outing. The Cowboys spotted the New York Jets a 3-0 lead midway through the first quarter, then scored the next 30 points en route to a 37-22 victory as 1.5-point underdogs.

Carolina (2-3 SU/3-2 ATS) found itself in a 17-0 hole vs. Miami, early in the second quarter. But the Panthers rallied and ultimately won 27-24 on a TD with 1:59 remaining, cashing as 1.5-point underdogs.

Dallas opened -3.5 at The SuperBook, with no early movement. The total inched from 49.5 to 49 Sunday night.

Cleveland Browns vs. Pittsburgh Steelers Odds

• Opening point spread: Steelers -4.5
• Opening moneyline: Steelers TBA/Browns TBA
• Opening total: Over/Under 37.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Pittsburgh (3-1 SU/2-2 ATS) is coming off its bye week after spending Week 4 in Dublin, Ireland. In that setting, the Steelers blew almost all of a 24-6 lead, holding on for a 24-21 victory as 2.5-point underdogs.

Cleveland (1-4 SU/2-3 ATS) had a back-and-forth battle vs. Minnesota in Week 5, with both teams on the road in London. The Browns led 17-14 almost the entire fourth quarter, but gave up a TD with 25 seconds remaining in a 21-17 loss getting 3.5 points.

The SuperBook opened Pittsburgh -4.5 in the NFL odds Week 6 market, with no movement as of 9:30 p.m. ET Sunday night.

New England Patriots vs. New Orleans Saints Odds

• Opening point spread: Patriots -3.5 (-105)
• Opening moneyline: Patriots TBA/Saints TBA
• Opening total: Over/Under 44.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: New Orleans (1-4 SU/2-3 ATS) is widely expected to be the NFL's worst team this season. But the Saints still broke through in Week 5 for their first win. New Orleans rallied from a 14-3 second-quarter deficit to beat the New York Giants 26-14.

The Saints rode big plays to cashing as 2.5-point home favorites. Spencer Rattler connected with Rashid Shaheed on an 87-yard touchdown pass, and Saints safety Jordan Howden had an 86-yard scoop-and-score on a Giants fumble.

New England (2-2 SU and ATS) is in the midst of its Week 5 assignment. The Patriots are at Buffalo on Sunday Night Football.

The SuperBook opened Pats-Saints at New England -3.5 (-105) and quickly moved to -3 (-105). But once Patriots-Bills kicked off, Patriots-Saints came off the board. Pats-Bills will go back up Monday morning.

The total opened at 44.5 and sped to 46.

Tennessee Titans vs. Las Vegas Raiders Odds

• Opening point spread: Raiders -6.5
• Opening moneyline: Raiders TBA/Titans TBA
• Opening total: Over/Under 41.5 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Tennessee (1-4 SU/2-3 ATS) nabbed the most alarming win of Week 5. Two minutes into the fourth quarter, and already trailing 21-6, the Titans gave up what appeared to be a 72-yard Eddie Demercado touchdown run.

But Demercado let go of the ball before crossing the goal line, and the ball rolled out of bounds in the end zone. Given new life, Cam Ward & Co. scored the final 16 points, winning 22-21 on a final-seconds field goal. Tennessee was a 7.5-point road underdog.

Las Vegas (1-4 SU and ATS) took a 3-0 lead late in the first quarter at Indianapolis. Then the Raiders did Raider things, giving up 40 straight points in losing 40-6 as 7-point road pups.

On Sunday night, The SuperBook opened Titans-Raiders at Las Vegas -6.5 and moved to -6 within a half-hour.

San Francisco 49ers vs. Tampa Bay Buccaneers Odds

• Opening point spread: Buccaneers -3
• Opening moneyline: 49ers TBA/Buccaneers TBA
• Opening total: Over/Under 48.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: San Francisco (4-1 SU and ATS) was missing QB Brock Purdy and wideouts Jauan Jennings and Ricky Pearsall in the Week 4 Thursday night game. As such, the Niners were 8-point road 'dogs vs. the Los Angeles Rams.

But Mac Jones & Co. got out to a 14-0 lead, then hung in to notch a 26-23 overtime upset.

Tampa Bay (4-1 SU/3-2 ATS) recorded a big Week 5 road win. Caught in a shootout at Seattle, the Bucs trailed 35-28 late in the fourth quarter. But Baker Mayfield & Co. put together a TD drive to tie it, the Bucs' defense got an interception, and Tampa won 38-35 on a final-seconds field goal.

The Buccaneers were 3.5-point underdogs.

For Niners-Bucs, The SuperBook opened Tampa -3 in NFL Week 6 odds.

"We took a sharp bet on Tampa -2.5 on Thursday," SuperBook risk manager Casey Degnon said, alluding to a bet placed on last week's lookahead line. "That, combined with the Bucs winning in Seattle today, made us open this game at -3.

"San Fran is also still really banged up, and this is a game where I could see the public being one-way traffic on the Buccaneers."

Cincinnati Bengals vs. Green Bay Packers Odds

• Opening point spread: Packers -14.5
• Opening moneyline: Packers TBA/Bengals TBA
• Opening total: Over/Under 45 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Green Bay (2-1-1 SU/2-2 ATS) had a bye in Week 5, and probably need it. In Week 4, the Packers were 6.5-point favorites at Dallas and and barely escaped with a 40-40 overtime tie.

Cincinnati (2-3 SU/1-4 ATS) dug itself into a 28-3 hole through three quarters before Detroit let off the gas. The Bengals lost 37-24 catching 9.5 points at home.

Green Bay opened as hefty 14.5-point home chalk vs. Cincy in The SuperBook's Week 6 NFL odds. As of 9:30 p.m. ET Sunday, there's been no spread movement, but the total went from 45 to 44.5.

Detroit Lions vs. Kansas City Chiefs Odds

• Opening point spread: Chiefs -1.5
• Opening moneyline: Chiefs TBA/Lions TBA
• Opening total: Over/Under 50.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

OPENING ODDS UPDATE: Detroit (4-1 SU and ATS) did pretty much what was expected in Week 5. The Lions built a 28-3 lead over three quarters at Cincinnati and coasted to a 37-24 victory giving 9.5 points on the road.

Kansas City (2-2 SU and ATS) still has Week 5 work to do. The Chiefs are in Jacksonville on Monday night.

The SuperBook opened K.C. a slim 1.5-point home favorite vs. Detroit, with no movement Sunday night.

"A good SNF game with a close spread means that both sides will see love throughout the week," SuperBook risk manager Casey Degnon said. "This is also a game where I think customers will be fighting over themselves to bet the Over.

"I'm not sure about the side. But I think we'll be looking for a low-scoring affair Sunday night."

Buffalo Bills vs. Atlanta Falcons Odds

• Opening point spread: Bills -5
• Opening moneyline: Bills TBA/Falcons TBA
• Opening total: Over/Under 50 points scored
• Time: 7:15 p.m. ET Monday (ESPN)

OPENING ODDS UPDATE: Buffalo (4-0 SU/2-2 ATS) is on the field right now, hosting the New England Patriots in Sunday Night Football.

Atlanta (2-2 SU and ATS) is coming off its bye. In Week 4, the Falcons took advantage of Jayden Daniels' absence to beat Washington 34-27 laying 2.5 points at home.

Bills-Falcons opened at Buffalo -5 in The SuperBook's NFL odds Week 6 market. Once Patriots-Bills kicked off, Bills-Falcons was taken off the board. Bills Falcons will go back up Monday morning.

"I'm not sure about straight bets on the spread. But considering the fact that the Bills are a favorite in prime time, we will need the other side," SuperBook risk manager Casey Degnon said. "All the parlays and teasers that survive the day will be ending with the Bills.

"I think the total will be a popular bet, as well. But not as much as Buffalo just to win. I anticipate we'll be rooting for Atlanta come Monday night."

Chicago Bears vs. Washington Commanders Odds

• Opening point spread: Commanders -4.5
• Opening moneyline: Commanders TBA/Bears TBA
• Opening total: Over/Under 50.5 points scored
• Time: 8:15 p.m. ET Monday (ABC)

OPENING ODDS UPDATE: It took a little while for Jayden Daniels to reacclimate, after missing two games for Washington (3-2 SU and ATS). But after falling behind 10-0 in the first quarter, the Commanders did the rest of the scoring in a 27-10 victory as 3-point road 'dogs vs. the L.A. Rams.

Chicago (2-2 SU and ATS) has a two-game win streak for the first time since stringing together three straight wins from Weeks 4-6 last season. That three-game run was followed by a season-killing 10-game losing streak.

The Bears are coming off a bye. In Week 4, Chicago was a 1.5-point 'dog at Las Vegas and won 25-24 on a late touchdown. A blocked field goal secured the Bears' victory.

The SuperBook opened Washington -4.5 vs. Chicago, with no movement Sunday night.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson