NFL Week 13 Odds: Lines, Spreads, Betting Trends for All 16 Games

Patrick Everson Sports Betting Expert

13 minute read

2025 NFL Week 13 Odds

NFL Week 13 odds are top-heavy, with four of the most notable matchups taking place before the weekend. That includes a Thanksgiving Day feast of three games.

Leading the way in Turkey Day Week 13 NFL odds: Green Bay Packers vs. Detroit Lions. Then it's Kansas City Chiefs vs. Dallas Cowboys, and Cincinnati Bengals vs. Baltimore Ravens.

Here’s everything you need to know about NFL odds Week 13: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on NFL Week 13 odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: David Banks/Imagn Images)

2025 NFL Odds for Week 13

Green Bay Packers vs. Detroit Lions Odds

• Opening point spread: Lions -3
• Opening moneyline: Lions TBA/Packers TBA
• Opening total: Over/Under 48.5 points scored
• Time: 1 p.m. ET Thursday (FOX)

OPENING ODDS UPDATE: Detroit (8-4 SU/7-5 ATS) barely got out of Week 12 without damage. The Lions were 14-point home favorites vs. the Giants, yet didn't lead even one second of regulation.

But Detroit erased a 27-17 fourth-quarter deficit, forced overtime by tying it at 27, then won 34-27 in the extra period. And although the Lions didn't cover, they are now 14-0 SU/13-1 ATS in their last 14 games after a SU loss.

Green Bay (7-3-1 SU/4-7 ATS) didn't have nearly as much drama against Minnesota. The Packers breezed to a 23-6 victory laying 6.5 points at home.

On Sunday night, The SuperBook opened Packers-Lions at Detroit -3 in the NFL odds Week 13 market.

"There was some money on Packers +3 in the lookahead market, but nothing that caused us to change the number. We should see money both ways in this game," SuperBook vice president John Murray said.

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Kansas City Chiefs vs. Dallas Cowboys Odds

• Opening point spread: Chiefs -3.5
• Opening moneyline: Chiefs TBA/Cowboys TBA
• Opening total: Over/Under 50.5 points scored
• Time: 4:30 p.m. ET Thursday (CBS)

OPENING ODDS UPDATE: Kansas City (6-5 SU and ATS) might've seen its playoff hopes flash before its eyes at various junctures of a Week 12 home game vs. Indianapolis. The Chiefs trailed 14-3 in the second quarter and 20-9 entering the fourth quarter.

However, Patrick Mahomes & Co. rallied to tie it at 20 on a final-seconds field goal. K.C. then went on to win 23-20 in overtime, while failing to cover as 4.5-point home chalk.

Dallas (5-5-1 SU/6-5 ATS) might've just saved its season with a big comeback win against defending Super Bowl champion Philadelphia. The Cowboys trailed 21-0 in the second quarter and 21-7 at halftime.

But Dallas allowed no second-half points, while Dak Prescott & Co. got it together enough for the Cowboys to win 24-21. Dallas, a 3-point home underdog, clinched it on a field goal as time expired.

For Chiefs-Cowboys, The SuperBook opened K.C. -3.5 and adjusted slightly to -3.5 (even) in short order. The total was more so on the move, going from 50.5 to 51.5 in NFL Week 13 odds.

"I think there will be public support for Dallas, especially after the comeback today against the Eagles," SuperBook VP John Murray said Sunday night. "This should be one of the highest-rated and most-bet games of the NFL regular season."

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Cincinnati Bengals vs. Baltimore Ravens Odds

• Opening point spread: Ravens -7.5
• Opening moneyline: Ravens TBA/Bengals TBA
• Opening total: Over/Under 51.5 points scored
• Time: 8:20 p.m. ET Thursday (NBC)

OPENING ODDS UPDATE: Cincinnati (3-8 SU/4-7 ATS) is set for the possible return of QB Joe Burrow, out since a Week 2 toe injury. But it's probably too late, after another loss in Week 12.

The Bengals fell to New England 26-20 as 7-point home underdogs, their fourth consecutive SU setback and eighth in the last nine games.

On the flip side, Baltimore (6-5 SU/5-6 ATS) is now tied with Pittsburgh atop the AFC North, after a 1-5 SU and ATS start. In Week 12, the Ravens topped the Jets 23-10, just short of covering as 14-point home favorites. It was Baltimore's fifth consecutive win (3-2 ATS).

"We have the Ravens -7.5 while we monitor the situation with Joe Burrow," SuperBook vice president John Murray said of Sunday night's opening line. "This number was more like 11.5/10.5 when we didn’t think there was much chance of Burrow playing."

Chicago Bears vs. Philadelphia Eagles Odds

• Opening point spread: Eagles -7
• Opening moneyline: Eagles TBA/Bears TBA
• Opening total: Over/Under 44.5 points scored
• Time: 3 p.m. ET Friday (Prime)

OPENING ODDS UPDATE: Philadelphia (8-3 SU/7-4 ATS) was on cruise control by 3.5 minutes into the second quarter, leading Dallas 21-0. But the Eagles didn't score another point and stunningly lost 24-21 laying 3 points on the road.

Chicago is surprisingly 8-3 SU/6-4-1 ATS, after opening the season with an Over/Under win total of 8.5. In Week 12, the Bears edged Pittsburgh 31-28 to push as 3-point home favorites.

After an 0-2 SU and ATS start, Caleb Williams & Co. are 8-1 SU/7-2 ATS. Still, The SuperBook opened Philly as 7-point chalk Sunday night in Week 13 NFL odds.

"Chicago keeps on winning close games. We’ll need the Bears on Friday," SuperBook VP John Murray said. "Philadelphia will be in a lot of teasers and moneyline parlays, especially coming off that loss to Dallas."

Houston Texans vs. Indianapolis Colts Odds

• Opening point spread: Colts -3.5
• Opening moneyline: Colts TBA/Texans TBA
• Opening total: Over/Under 45.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Indianapolis (8-3 SU/6-5 ATS) had a great chance to pull off a road upset and seriously impede Kansas City hopes of getting to the playoffs. But the Colts couldn't make a 20-9 fourth-quarter lead stand up, getting forced to overtime tied at 20.

Indy ultimately lost 23-20, while covering as a 4.5-point pup.

Houston (6-5 SU and ATS) climbed back above .500 with an upset victory in the Week 12 Thursday nighter. The Texans closed as 4.5-point home underdogs vs. Buffalo and notched a 23-19 victory, their third consecutive win (2-1 ATS).

The SuperBook opened the Colts as 3.5-point home chalk in NFL Week 13 odds, an adjustment from last week's lookahead line, which toggled between Colts -4.5/-4.

"Houston is playing well of late, especially on defense," SuperBook vice president John Murray said Sunday night. "The Texans also have the benefit of three extra days rest before they play an Indianapolis team that threw the kitchen sink at Kansas City today. This sets up to be a battle."

Los Angeles Rams vs. Carolina Panthers Odds

• Opening point spread: Rams -7
• Opening moneyline: Rams TBA/Panthers TBA
• Opening total: Over/Under 42 points scored
• Time: 1 p.m. ET Sunday (FOX)

EARLY WEEK UPDATE: Carolina (6-6 SU/7-5 ATS) has alternated wins and losses over its past six games. In the Week 12 Monday nighter, the Panthers fell to San Francisco 20-9 catching 7.5 points on the road.

On Sunday night, the SuperBook opened Rams-Panthers at L.A. -9.5 Sunday night. Monday morning, the Rams advanced to -10, and then the game came off the board once the Panthers-Niners game kicked off. Rams-Panthers will go back up Tuesday morning.

OPENING ODDS UPDATE: Los Angeles (8-2 SU/7-3 ATS) is in the midst of its Week 12 assignment, hosting Tampa Bay in the Sunday night game.

Carolina (6-5 SU/7-4 ATS) still has Week 12 work to do, traveling to San Francisco on Monday night.

Still, The SuperBook went ahead and opened Rams-Panthers at L.A. -9.5. The game came off the board once Bucs-Rams kicked off Sunday night, and it will go back up Monday morning.

San Francisco 49ers vs. Cleveland Browns Odds

• Opening point spread: 49ers -6.5
• Opening moneyline: 49ers TBA/Browns TBA
• Opening total: Over/Under 41.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

EARLY WEEK UPDATE: San Francisco (8-4 SU and ATS) overcame three Brock Purdy interceptions in the first half to win the Week 12 Monday night game. The 49ers topped Carolina 20-9 giving 7.5 points at home.

It was Purdy's second game back after sitting out since Week 4 with a toe injury.

Niners-Browns opened at San Fran -6.5 Sunday night at The SuperBook. On Monday, the number briefly dipped to 49ers -5.5, then -5, before rebounding to settle at -6 by early evening.

Once Panthers-49ers kicked off Monday night, 49ers-Browns was taken off the board, and it will go back up Tuesday morning.

OPENING ODDS UPDATE: San Francisco (7-4 SU and ATS) isn't yet out of Week 12. The Niners host Carolina on Monday Night Football.

Cleveland (3-8 SU/5-6 ATS) gave rookie QB Shedeur Sanders his first start and got a positive result. The Browns closed as 3-point pups at Las Vegas and won 24-10, with the defense keeping the Raiders out of the end zone until late in the fourth quarter.

Sanders didn't light it up, completing just 11 of 20 passes. But those 11 completions went for 209 yards, including a swing pass to Dylan Sampson that turned into a 66-yard TD that put the Browns up 24-3 midway through the fourth quarter.

Niners-Browns opened at San Fran -6.5 in The SuperBook's NFL odds Week 13 market, with no movement Sunday night.

Jacksonville Jaguars vs. Tennessee Titans Odds

• Opening point spread: Jaguars -7
• Opening moneyline: Jaguars TBA/Titans TBA
• Opening total: Over/Under 42 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Jacksonville (7-4 SU and ATS) was in a back-and-forth battle with Arizona, getting taken to overtime on a final-seconds Cardinals field goal that tied it at 24. But the Jaguars then won it 27-24 on a field goal in OT, covering as 2.5-pont road favorites.

Tennessee (1-10 SU/4-7 ATS) is on a six-game nosedive, though it has covered the past three games. In Week 12, the Titans fell to Seattle 30-24 as 12.5-point home 'dogs, cashing for spread bettors on a last-minute touchdown.

The SuperBook opened Jags-Titans at Jacksonville -7, and the line was stable Sunday night.

Arizona Cardinals vs. Tampa Bay Buccaneers Odds

• Opening point spread: Buccaneers -6
• Opening moneyline: Buccaneers TBA/Cardinals TBA
• Opening total: Over/Under 49 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Tampa Bay (6-4 SU/5-5 ATS) is on the field right now, visiting the L.A. Rams in the Week 11 Sunday night game.

Arizona (3-8 SU/5-6 ATS) heads to Week 13 on a dreadful on 1-9 SU plunge. The Cardinals had a chance in Week 12, tying Jacksonville at 24 on a final-seconds field goal to force overtime. But Arizona then lost 24-21 getting 2.5 points at home.

For Cards-Bucs, The SuperBook opened Tampa Bay -6 Sunday night, though the game came off the board once Bucs-Rams kicked off. Cards-Bucs will go back up Monday morning.

New Orleans Saints vs. Miami Dolphins Odds

• Opening point spread: Dolphins -5.5
• Opening moneyline: Dolphins TBA/Saints TBA
• Opening total: Over/Under 42.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Miami (4-7 SU/6-5 ATS) is coming off its bye, after winning two in a row and three of four SU and ATS. In Week 11, the Dolphins edged Washington 16-13 in overtime, cashing as 2.5-point neutral-site favorites in Madrid, Spain.

New Orleans (2-9 SU/3-8 ATS) was a 1,5-point home favorite in Week 12, looking for its second straight victory. It didn't happen, as the Saints lost to Atlanta 24-10.

The SuperBook opened the Dolphins -5.5 vs. the Saints, with no movement Sunday night.

Atlanta Falcons vs. New York Jets Odds

• Opening point spread: Falcons -2.5
• Opening moneyline: Falcons TBA/Jets TBA
• Opening total: Over/Under 39.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Atlanta (4-7 SU and ATS), without Michael Penix (knee) for the rest of the season, still halted a five-game purge. Kirk Cousins and the Falcons topped New Orleans 24-10 as 1.5-point road underdogs.

New York (2-9 SU/4-7 ATS) took a 7-0 lead over Baltimore late in the second quarter. But the Jets managed just three points the rest of the way and lost 23-10, while covering as 14-point underdogs.

Falcons-Jets opened at Atlanta -2.5 in The SuperBook's NFL Week 13 odds, with no early movement.

Minnesota Vikings vs. Seattle Seahawks Odds

• Opening point spread: Seahawks -8
• Opening moneyline: Seahawks TBA/Vikings TBA
• Opening total: Over/Under 43.5 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Seattle (8-3 SU and ATS) is back on the winning track, after a Week 11 road setback to the Rams. In Week 12, the Seahawks built a 30-10 lead by midway through the third quarter en route to a 30-24 victory at Tennessee.

The Seahawks were 12.5-point favorites and nearly covered, leading 30-17 late in the game before giving up a touchdown in the final minute.

Minnesota (4-7 SU and ATS) has dumped three in a row as part of a likely season-killing 1-5 SU and ATS purge. In Week 12, the Vikings were 6.5-point underdogs at Green Bay and mustered just two first-half field goals in a 23-6 loss.

The SuperBook opened Vikes-Seahawks at Seattle -8 and moved to -8.5 within 40 minutes Sunday night. The total got a bump, too, from 43.5 to 43 in Week 13 NFL odds.

Buffalo Bills vs. Pittsburgh Steelers Odds

• Opening point spread: Bills -3.5
• Opening moneyline: Bills TBA/Steelers TBA
• Opening total: Over/Under 47.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Buffalo (7-4 SU/5-5 ATS) dumped two of its last three games and is 3-4 SU and ATS over its last seven outings. In the Week 12 Thursday night game, the Bills closed as 4.5-point road favorites and lost to Houston 23-19.

After a 4-1 SU and ATS start, Pittsburgh has dropped four of its last six games (2-3-1 ATS). In Week 12, the Steelers fell to Chicago 31-28, pushing as 3-point road 'dogs on a TD midway through the fourth quarter.

Buffalo opened as 3.5-point road chalk vs. Pittsburgh in The SuperBook's NFL odds Week 13 market. There's been no movement Sunday night.

"There's no notable action to speak of on this game. I assume we’ll need the Steelers," SuperBook vice president John Murray said.

Las Vegas Raiders vs. Los Angeles Chargers Odds

• Opening point spread: Chargers -9.5
• Opening moneyline: Chargers TBA/Raiders TBA
• Opening total: Over/Under 42.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Los Angeles (6-4 SU/5-5 ATS) had its bye week right after seeing its three-game SU win streak end. In Week 11, the Chargers stunningly got boatraced 35-6 giving 3 points at Jacksonville.

Las Vegas (2-9 SU/4-7 ATS) continued to struggle, even while getting to face rookie Shedeur Sanders in his first NFL start. The Raiders dug themselves into a 24-3 hole by midway through the fourth quarter and lost 24-10 as 3-point home favorites.

Raiders-Chargers opened at Los Angeles -9.5 in The SuperBook's NFL Week 13 odds. In short order Sunday night, the line went to Chargers -10, while the total slid from 42.5 to 41.5, then 41.

Denver Broncos vs. Washington Commanders Odds

• Opening point spread: Broncos -6.5
• Opening moneyline: Broncos TBA/Commanders TBA
• Opening total: Over/Under 43.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

OPENING ODDS UPDATE: Denver (9-2 SU/5-6 ATS) is winning by eyelashes week after week, but is in great shape coming off the bye. In Week 11, the Broncos edged Kansas City 22-19 on a final-seconds field goal, cashing as 4-point home pups.

Denver is on an 8-0 SU tear (5-3 ATS), with six of those victories coming games with one-score margins.

Washington (3-7 SU and ATS) is also coming off the bye, and needs it after a rough first 10 weeks. The Commanders were a Cinderella story last season, reaching the NFC Championship Game. It's unlikely that they'll sniff the postseason this year.

One reason for that: Jayden Daniels (elbow) has missed the last two games and five games overall. In Week 11, Washington was a 2.5-point 'dog vs. Miami and lost 16-13 in overtime in Madrid, Spain.

For Broncos-Commanders, Denver opened -6.5 in The SuperBook's Week 13 NFL odds. The only adjustment Sunday night was to the juice, with the Broncos going to -6.5 (-120).

New York Giants vs. New England Patriots Odds

• Opening point spread: Patriots -7
• Opening moneyline: Patriots TBA/Giants TBA
• Opening total: Over/Under 47.5 points scored
• Time: 8:15 p.m. ET Monday (ABC/ESPN)

OPENING ODDS UPDATE: New England (10-2 SU/8-4 ATS) has the NFL's best SU record through 12 weeks. The Patriots reached double-digit wins by beating Cincinnati 26-20, just short of covering as 7-point road favorites.

New York (2-10 SU/7-5 ATS) were on the brink of one of this season's biggest upsets in Week 12. The Giants were 14-point 'dogs at Detroit and led throughout regulation, including 27-17 on an early fourth-quarter TD.

But New York ultimately allowed Detroit to tie it at 27 on a final-seconds field goal, then lost 34-27 in overtime.

The Pats opened as 7-point chalk vs. the Giants in The SuperBook's NFL Week 13 odds. There was no movement Sunday night.

"The Giants played a great game today, but came up just short. We’ll see how they rebound from what had to be a very disappointing loss," SuperBook VP John Murray said Sunday night.

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Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson