Last Updated Oct 23, 2022, 3:44 PM

Kansas City Chiefs vs. San Francisco 49ers Picks, Predictions, Odds

Week 7 of the NFL season continues Sunday afternoon as the Kansas City Chiefs travel to meet the San Francisco 49ers in an AFC-NFC matchup at Levi's Stadium in Santa Clara, California. Coverage begins at 4:25 p.m. ET on FOX.

KANSAS CITY CHIEFS vs. SAN FRANCISCO 49ERS BETTING PREDICTION

The big news ahead of this game comes from the 49ers. San Francisco made a giant splash, picking the carcass known as the Carolina Panthers, landing RB Christian McCaffrey for a slew of future draft picks. San Francisco didn't even have to give up a first-round pick for the marquee running back, who is expected to fly from Charlotte to San Francisco ahead of Sunday's game. He'll be given a playbook, and likely a handful of plays, but it might take a full week of practice with the team to get up to speed with his new organization.

Still, the addition of CMC gives the 49ers a huge injection of offensive talent. San Francisco has averaged 340.2 total yards per game (18th in the NFL), while posting 124.0 rushing yards per game (12th). The addition of McCaffrey will change that dramatically, as well as give QB Jimmy Garoppolo a nice safety-valve out of the backfield. The 49ers are averaging 20.3 PPG, but that should be improved, too.

It's all about defense for the 49ers, ranking No. 1 in total yards allowed (255.8), while ranking No. 2 in passing yards (168.3), rushing yards (87.5) and points allowed (14.8) per game. That will be put to the test against Chiefs QB Patrick Mahomes and the high-octane offense.

The Chiefs are averaging 382.3 total yards per game (6th), 275.8 passing yards (4th) and 29.8 points scored (1st). It's offense vs. defense, and it is likely that San Francisco puts up a nice fight before Kansas City pulls away in the second half in a rather high-scoring affair. The money came in on the Chiefs early, pushing the line from an open of -1 to -2.5, but after the CMC trade, the line is getting pushed down with the public jumping on the Niners. I don't think CMC's impact will be as large as those people think in this first game with just a day or two to prepare.

Score Prediction: Chiefs 30, 49ers 23
Best Bet: Chiefs -2 (-105)
Best Bet: OVER 48.5 (-110)

KANSAS CITY CHIEFS vs. SAN FRANCISCO 49ERS BETTING ODDS

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KANSAS CITY CHIEFS vs. SAN FRANCISCO 49ERS BETTING RESOURCES

Date: Sunday, Oct. 23, 2022
Matchup: AFC West vs. NFC West
Venue: Levi's Stadium
Location: Santa Clara, California
Time-TV: FOX, 4:25 p.m. ET

KANSAS CITY CHIEFS BETTING ANALYSIS

The Chiefs are coming off an emotional 24-20 setback at home against the Buffalo Bills, a game which was a key showdown for early supremacy in the AFC. It failed to cover, and Kansas City is now 1-4 ATS across the past five games overall. In four wins, Kansas City is averaging 35.5 PPG, while averaging just 18.5 PPG in two losses.

For totals, the Chiefs have hit the OVER at a 10-4 clip across the past 14 games overall, while going 6-1 to the OVER in the past seven road games.

As far as potential game props are concerned, Mahomes UNDER 288.5 (-110) is a great play. The 49ers are allowing just 168.3 passing yards per game, and Mahomes and company will not produce the usual type numbers it puts up at GEHA Field at Arrowhead Stadium.

49ers QB Jimmy Garoppolo has the addition of CMC to the offense. (Getty Images)

SAN FRANCISCO 49ERS BETTING ANALYSIS

The 49ers have some impressive numbers against the spread, going 8-3 ATS in the past 11 games overall dating back to last season, while cashing in each of the past six games at home. The 49ers are also 6-0 ATS in the past six against teams with a winning overall record, while going 6-1 ATS in the past seven after a SU loss and 6-1 ATS in the past seven following a non-cover.

For totals, with the No. 1 defense and a struggling offense, you would expect plenty of UNDERs, and that's the case. The UNDER is 12-2 in the past 14 games overall, while going 4-0 in the past four games at home. The UNDER is 5-0 in the past five games against teams with a winning overall record, too.

On props, it might be a good idea to jump on the UNDER for RB Jeff Wilson Jr. at 57.5 yards if that becomes available again. It was temporarily taken off the board after news of the McCaffrey trade news broke.

KANSAS CITY CHIEFS vs. SAN FRANCISCO 49ERS BETTING TRENDS

  • Chiefs are 1-4 ATS in the past five games overall
  • 49ers are 8-3 ATS in the past 11 games overall
  • 49ers are 6-0 ATS in the past six home games
  • 49ers are 6-0 ATS in the past six vs. winning teams
  • OVER is 10-4 in the past 14 games overall for the Chiefs
  • OVER is 6-1 in the past seven road games for the Chiefs
  • UNDER is 12-2 in the past 14 games overall for the 49ers
  • UNDER is 4-0 in the past four home games for the 49ers
  • UNDER is 5-0 in the past five vs. winning teams for the 49ers
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