Clemson vs Arizona Picks, Odds | NCAA Tourney Sweet 16 Prediction

The Sweet 16 of NCAA Tourney begins this Thursday -- and the first matchup of the day we'll be breaking down is Clemson vs Arizona, which is scheduled for 7:09 p.m. ET on CBS.

The Wildcats are 7-point favorites on the spread in Thursday's contest; with the game total set at over/under 152 at most sportsbooks.

Here's everything you need to know about Clemson vs Arizona -- the latest betting odds, as well as our expert picks and prediction for this Sweet 16 NCAA Tournament matchup on Thursday, March 28.

Clemson vs Arizona Odds


Clemson vs Arizona Picks & Prediction

Clemson was bounced immediately in the ACC Tournament by Boston College, but the Tigers rebounded from that defeat to make the Sweet 16.

The Tigers are in their first Sweet 16 since 2018 after dominating New Mexico and holding off Baylor. The key to Clemson’s success in the first weekend was limiting those opponents to 9-of-47 from 3-point range.

Arizona took care of Long Beach State and Dayton in the first two rounds to erase last season’s disappointment of getting shocked by 15th-seeded Princeton in the opening round.

Since getting upset at Oregon State in late January, Arizona is 13-3 SU and 10-4-2 ATS the last 16 games. In that stretch, three of the four ATS losses came as a favorite of 12 points or more.

Arizona’s 3-point defense has been superb of late by not allowing an opponent to convert on better than 34% of its attempts from downtown in 12 straight games. Clemson has been hovering that range the last two games by hitting 33% against New Mexico and 35% against Baylor.

Clemson has been magnificent as an underdog this season at 8-1 ATS and 6-3 SU with two of those losses by two points or less.

The Tigers have proven they can step up to the challenge as an underdog and there is no reason to jump off that, even against Arizona.

Pick: Clemson +7 (-110)

Click this link for betting picks and predictions for all eight Sweet 16 matchups of the NCAA Tourney!

Clemson vs Arizona Game Time & TV Channel

Date: Thursday, March 28
Matchup: ACC vs Pac-12
Venue: Arena
Location: Los Angeles, CA
Time-TV: CBS, 7:09 p.m. ET

Clemson vs Arizona Betting Stats

2) Arizona Wildcats
(Pac-12, At-Large)

  • Futures: +1600
  • Region: +275
  • SU: 25-8
  • ATS: 21-11-1
  • O/U: 16-17
  • PPG: 89.5
  • OPPG: 73.2

6) Clemson Tigers
(ACC, At-Large)

  • Futures: +10000
  • Region: +2200
  • SU: 21-11
  • ATS: 17-14-1
  • O/U: 17-15
  • PPG: 78.1
  • OPPG: 71.2

March Madness Betting Resources

March Madness Sweet 16 Odds

The Sweet 16 of the NCAA Men's Tournament gets underway on Thursday, March 28 and Friday, March 29.

Check out the teams, odds, betting stats and much more on each of the four regions below: