Illinois vs Iowa State Picks, Odds | NCAA Tourney Sweet 16 Prediction

The Sweet 16 of NCAA Tourney begins this Thursday -- and the final matchup of the day we'll be breaking down is Illinois vs Iowa State, which is scheduled for 10:09 p.m. ET on TBS.

The Cyclones are short two-point favorites on the spread in Thursday's contest; with the game total set at over/under 146.5 at most sportsbooks.

Here's everything you need to know about Illinois vs Iowa State -- the latest betting odds, as well as our expert picks and prediction for this Sweet 16 NCAA Tournament matchup on Thursday, March 28.

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Illinois vs Iowa State Odds


Illinois vs Iowa State Picks & Prediction

A fantastic matchup wraps up the night in the East region in Boston as 2nd-seeded Iowa State hooks up with 3rd-seeded Illinois.

The Cyclones haven't skipped a beat since routing Houston to capture the Big 12 championship earlier this month.

ISU took care of South Dakota State and Washington State by double-digits apiece, extending the Cyclones' hot streak to five games.

Illinois captured the Big 10 tournament title and didn't let up in consecutive routs of Morehead State and Duquesne.

Granted, the Fighting Illini faced two teams that were seeded 14th and 11th, but Illinois easily cashed as double-digit favorites each time.

Terrence Shannon, Jr. has put in one of the best scoring tears in the country as the Illinois guard is averaging 32.5 points per game the last four contests.

The Illini have been a solid underdog this season at 4-1-1 ATS, but Illinois has been knocked out the last two seasons in the tournament in the 'dog role.

Iowa State has limited eight of its last nine opponents to 33% shooting or worse from 3-point range.

Let's lay the short number with the Cyclones to eliminate the Fighting Illini.

Pick: Iowa State -2 (-110)

Click this link for betting picks and predictions for all eight Sweet 16 matchups of the NCAA Tourney!

Illinois vs Iowa State Game Time & TV Channel

Date: Thursday, March 28
Matchup: Big Ten vs Big 12
Venue: TD Garden
Location: Boston, MA
Time-TV: TBS, 10:09 p.m. ET

Illinois vs Iowa State Betting Stats

2) Iowa State Cyclones
(Big 12, Automatic)

  • Futures: +1900
  • Region: +550
  • SU: 27-7
  • ATS: 22-10-2
  • O/U: 16-18
  • PPG: 75.7
  • OPPG: 62.1

4) Alabama Crimson Tide
(SEC, At-Large)

  • Futures: +3200
  • Region: +650
  • SU: 21-11
  • ATS: 16-15-1
  • O/U: 24-8
  • PPG: 90.8
  • OPPG: 80.4

March Madness Betting Resources

March Madness Sweet 16 Odds

The Sweet 16 of the NCAA Men's Tournament gets underway on Thursday, March 28 and Friday, March 29.

Check out the teams, odds, betting stats and much more on each of the four regions below: