2025 College Football Odds Week 7: Lines, Spreads, Betting Trends on Biggest Games

Patrick Everson Sports Betting Expert

4 minute read

The College Football Odds Week 7 market includes multiple matchups of Top 25 teams.

Indiana vs. Oregon features two top-10 teams, highlighting college football Week 7 odds. Oklahoma vs. Texas is also on tap, in the Red River Rivalry, and Ohio State aims to keep rolling at Illinois.

Here’s everything you need to know about college football odds Week 7: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 7 college football odds and action.

Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

2025 College Football Odds for Week 7

Ohio State vs. Illinois Odds

• Opening point spread: Ohio State -16
• Opening moneyline: Ohio State TBA/Illinois TBA
• Opening total: Over/Under 50.5 points scored
• Time: Noon ET Saturday (FOX)

OPENING ODDS UPDATE: No. 1 Ohio State (5-0 SU/4-0-1 ATS) trailed Minnesota 3-0 midway through the first quarter. Then the Buckeyes scored the game's final 42 points – 21 in each half – in a 42-3 blowout laying 23.5 points at home.

No. 17 Illinois (5-1 SU and ATS) rebounded from its 63-10 wipeout loss at Indiana by winning its next two games. The Fighting Illini were 6.5-point home underdogs to USC and won outright 34-32 in Week 5. In Week 6, the Illini topped Purdue 43-27 laying 7.5 points at home.

Oddsmakers aren't foreseeing a close game between Ohio State and Illinois. Circa Sports opened the Buckeyes as 16.5-point road favorites at approximately 1:55 p.m. ET Sunday. However, the line quickly moved toward Illinois, going straight to Ohio State -14.5, then settling at -15.

The total opened at 50.5 and inched to 51 in the college football odds Week 7 market.

Alabama vs. Missouri Odds

• Opening point spread: Alabama -4
• Opening moneyline: Alabama TBA/Missouri TBA
• Opening total: Over/Under 56.5 points scored
• Time: Noon ET Saturday (ABC)

OPENING ODDS UPDATE: No. 8 Alabama (4-1 SU and ATS) saved its spread bettors and provided a bad beat for Vanderbilt backers in Week 6. Leading 23-14 and in position to run out the clock, the Crimson Tide got a 20-yard Jam Miller touchdown run with 17 seconds remaining.

That gave the Tide a 30-14 win and cover as 12.5-point favorites.

No. 14 Missouri (5-0 SU/3-2 ATS) is fresh for this showdown, coming off a Week 6 bye. For that matter, Week 5 was something of a bye, as the Tigers drubbed MAC foe UMass 42-6. But Mizzou failed to cash as massive 44.5-point home chalk.

Circa Sports opened Alabama-Missouri at Tide -4 in college football Week 7 odds, with no early movement. But the total was on the move right out of the gate, sliding from 56 to 53. It then rebounded to 53.5/54.

Indiana vs. Oregon Odds

• Opening point spread: Oregon -10
• Opening moneyline: Oregon TBA/Indiana TBA
• Opening total: Over/Under 51.5 points scored
• Time: 3:30 p.m. ET Saturday (CBS)

OPENING ODDS UPDATE: No. 3 Oregon (5-0 SU/4-1 ATS) is well-rested for this one, coming off a bye after a huge Week 5 victory. The Ducks went to Penn State as 4-point underdogs and exited with a 30-24 overtime victory. Oregon blew a 17-3 fourth-quarter lead, but still got the W.

No. 7 Indiana (5-0 SU/3-2 ATS) is also fresh for this matchup, getting a bye in Week 6. In Week 5, the Hoosiers held off Iowa 20-15, but failed to cover as 9.5-point road favorites.

Oregon opened as 10-point home chalk in Circa Sports' college football odds Week 7 market. That number adjusted to Ducks -9 within a few minutes Sunday. The total was a bigger mover out of the gate, shooting from 51.5 to 55

Oklahoma vs. Texas Odds

• Opening point spread: Texas -3
• Opening moneyline: Texas TBA/Oklahoma TBA
• Opening total: Over/Under 42.5 points scored
• Time: 3:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: No. 6 Oklahoma (5-0 SU/3-2 ATS) had a bye in Week 5 and a breezy easy game in Week 6. The Sooners rolled over Kent State 44-0, just a field goal shy of covering a huge 46.5-point spread.

Texas (3-2 SU/1-4 ATS) has officially made its way to We're In Trouble Land. The Longhorns closed as 3.5-point favorites at Florida and lost outright 29-21. With two losses and in a tough SEC, Texas can't absorb another loss at this point.

Texas was ranked No. 9 before the Florida loss, then dropped out of the AP poll altogether afterward.

However, Circa Sports still opened Texas -3 for this neutral-site game at the Cotton Bowl in Dallas. That's due in no small part to Oklahoma QB John Mateer (hand) expected to miss his second straight game.

The Longhorns almost immediately dipped to -2.5, then returned to -3, where the number sits at 2:30 p.m. ET Sunday.

Circa opened the total at 42.5 in Week 7 college football odds and went to 42 in short order.

Michigan vs. USC Odds

• Opening point spread: USC -2
• Opening moneyline: Southern Cal TBA/Michigan TBA
• Opening total: Over/Under 54.5 points scored
• Time: 7:30 p.m. Saturday (NBC)

OPENING ODDS UPDATE: Southern Cal (4-1 SU/2-3 ATS) was off in Week 6, recovering from a tough Week 5 road upset. The Trojans were 6.5-point favorites vs. Illinois, but came up short in a 34-32 loss.

Michigan is also 4-1 SU/2-3 ATS after a Week 6 win. The Wolverines spotted Wisconsin a 7-0 lead, then scored the next 24 points en route to a 24-10 win laying 17.5 points at home.

Michigan-USC opened Trojans -2 in Circa Sports' college football odds Week 7, and the number promptly went to -3, then receded to -2.5. The total is up a tick, as well, from 54.5 to 55.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson