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Featured Last Updated Sep 15 2026, 11:48 AM

LSU vs. Ole Miss Prediction: Lane Kiffin Wins in Reunion with Ole Miss

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
15 minute read
LSU vs. Ole Miss Prediction: Lane Kiffin Wins in Reunion with Ole Miss

Updated on 9/15/26

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The LSU Tigers will take on the Ole Miss Rebels in this week's college football action. Kickoff is set for 7:30p.m. EST at Vaught-Hemingway Stadium in Oxford, MS. The game will be broadcast live onABC. Here's everything you need to know about LSU vs. Ole Miss odds, the latest college football spreads, college football over/unders and more.

LSU @ MISS Odds

  • Full Game
  • 1H
  • 1Q
  • 4Q
  • 2Q
  • 3Q
  • Spread
  • Total
  • Moneyline
LSU Tigers 197 LSU
+1.5 -110 -2.5 -115 + -2.5 -112 + -2.5 -115 + N/A N/A -1.5 -115 + -2.5 -120 + -2.5 -107 + -3 -110  
Ole Miss Rebels 198 Ole Miss
-1.5 -110 +2.5 -105 + +2.5 -105 + +2.5 -105 + N/A N/A +1.5 -115 + +2.5 -110 + +2.5 -117 + +3 -110  
LSU Tigers 197 LSU
o57.5 -108 o30.5 -110 + o30.5 -110 + o30.5 -112 + N/A N/A o30.5 -115 + o30.5 -115 + o30.5 -118 + o59.5 -105  
Ole Miss Rebels 198 Ole Miss
u57.5 -112 u30.5 -110 + u30.5 -108 + u30.5 -108 + N/A N/A u30.5 -115 + u30.5 -115 + u30.5 -109 + u59.5 -115  
LSU Tigers 197 LSU
-105 -150 + -145 + -148 + -150 + -148 + N/A N/A -152 + -155  
Ole Miss Rebels 198 Ole Miss
-115 +125 + +125 + +124 + +123 + +122 + N/A N/A +118 + +130  
LSU Tigers 197 LSU
+1.5 -110 -0.5 +105 + -0.5 even + -0.5 even + N/A -1.5 +108 + -0.5 +105 + -0.5 +105 + -1.5 +108 + -3 -110  
Ole Miss Rebels 198 Ole Miss
-1.5 -110 +0.5 -135 + +0.5 -130 + +0.5 -130 + N/A +1.5 -130 + +0.5 -130 + +0.5 -140 + +1.5 -139 + +3 -110  
LSU Tigers 197 LSU
o57.5 -108 o13.5 -125 + o13.5 -118 + o13.5 -120 + N/A o13.5 -116 + o13.5 -125 + o13.5 -120 + o13.5 -121 + o59.5 -105  
Ole Miss Rebels 198 Ole Miss
u57.5 -112 u13.5 -105 + u13.5 -110 + u13.5 -110 + N/A u13.5 -106 + u13.5 even + u13.5 -110 + u13.5 -108 + u59.5 -115  
LSU Tigers 197 LSU
-105 -140 + -150 + -140 + N/A -144 + N/A N/A -148 + -155  
Ole Miss Rebels 198 Ole Miss
-115 +110 + +115 + +110 + N/A +122 + N/A N/A +114 + +130  
LSU Tigers 197 LSU
+1.5 -110 -0.5 -105 + N/A N/A N/A -1.5 +122 + -0.5 +120 + N/A N/A -3 -110  
Ole Miss Rebels 198 Ole Miss
-1.5 -110 +0.5 -135 + N/A N/A N/A +1.5 -148 + +0.5 -155 + N/A N/A +3 -110  
LSU Tigers 197 LSU
o57.5 -108 o14.5 -115 + N/A N/A N/A o14.5 -108 + o14.5 even + N/A N/A o59.5 -105  
Ole Miss Rebels 198 Ole Miss
u57.5 -112 u14.5 -125 + N/A N/A N/A u14.5 -112 + u14.5 -125 + N/A N/A u59.5 -115  
LSU Tigers 197 LSU
-105 -140 + N/A N/A N/A -122 + N/A N/A N/A -155  
Ole Miss Rebels 198 Ole Miss
-115 even + N/A N/A N/A +104 + N/A N/A N/A +130  
LSU Tigers 197 LSU
+1.5 -110 N/A N/A N/A N/A -1.5 +112 + -0.5 even + N/A N/A -3 -110  
Ole Miss Rebels 198 Ole Miss
-1.5 -110 N/A N/A N/A N/A +1.5 -136 + +0.5 -125 + N/A N/A +3 -110  
LSU Tigers 197 LSU
o57.5 -108 o16 -120 + N/A N/A N/A o16.5 -130 + o16.5 -135 + N/A N/A o59.5 -105  
Ole Miss Rebels 198 Ole Miss
u57.5 -112 u16 -120 + N/A N/A N/A u16.5 +106 + u16.5 +105 + N/A N/A u59.5 -115  
LSU Tigers 197 LSU
-105 -170 + N/A N/A N/A -124 + N/A N/A N/A -155  
Ole Miss Rebels 198 Ole Miss
-115 +130 + N/A N/A N/A +106 + N/A N/A N/A +130  
LSU Tigers 197 LSU
+1.5 -110 N/A N/A N/A N/A -1.5 +138 + -0.5 +115 + N/A N/A -3 -110  
Ole Miss Rebels 198 Ole Miss
-1.5 -110 N/A N/A N/A N/A +1.5 -170 + +0.5 -150 + N/A N/A +3 -110  
LSU Tigers 197 LSU
o57.5 -108 o13.5 -135 + N/A N/A N/A o13.5 -116 + o13.5 -110 + N/A N/A o59.5 -105  
Ole Miss Rebels 198 Ole Miss
u57.5 -112 u13.5 -105 + N/A N/A N/A u13.5 -106 + u13.5 -115 + N/A N/A u59.5 -115  
LSU Tigers 197 LSU
-105 -145 + N/A N/A N/A -115 + N/A N/A N/A -155  
Ole Miss Rebels 198 Ole Miss
-115 +105 + N/A N/A N/A -111 + N/A N/A N/A +130  
LSU Tigers 197 LSU
+1.5 -110 N/A N/A N/A N/A N/A N/A N/A N/A -3 -110  
Ole Miss Rebels 198 Ole Miss
-1.5 -110 N/A N/A N/A N/A N/A N/A N/A N/A +3 -110  
LSU Tigers 197 LSU
o57.5 -108 N/A N/A N/A N/A N/A o28.5 -105 + N/A N/A o59.5 -105  
Ole Miss Rebels 198 Ole Miss
u57.5 -112 N/A N/A N/A N/A N/A u28.5 -125 + N/A N/A u59.5 -115  
LSU Tigers 197 LSU
-105 N/A N/A N/A N/A N/A N/A N/A N/A -155  
Ole Miss Rebels 198 Ole Miss
-115 N/A N/A N/A N/A N/A N/A N/A N/A +130  

The LSU Tigers opened as a -3 point favorite over Ole Miss. The total is set at over/under 58.5 total points scored by both teams combined.

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Updated on 9/15/26

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LSU vs. Ole Miss Prediction

LSU's offensive profile is built on efficiency and discipline. They average 92 snaps per game while maintaining a 1.02% turnover-worthy play rate. This is elite-level execution. The offense doesn't create problems for itself.

On defense, LSU leads college football in yards allowed at 142 per game. They've generated immense pressure with 12 sacks forced, which ranks 1st nationally. This defensive line is arguably one of the best in college football. Trinidad Chambliss will face constant disruption up front. LSU's ability to generate pressure affects quarterback decision-making and timing throughout the game.

LSU has advantages on both sides of the ball. An efficient offense that minimizes mistakes paired with a defensive line that controls the line of scrimmage should give LSU control of the game on their home field. Ole Miss can certainly compete in this matchup, but LSU's dominance in pass-rush defense represents a significant obstacle.

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LSU vs. Ole Miss Prediction: LSU Tigers -2.5 (-120)

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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