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Featured Last Updated Oct 26 2026, 4:47 PM

Ohio State vs. USC Prediction: Jayden Maiava Leads Trojans Against Bucks

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
14 minute read
Ohio State vs. USC Prediction: Jayden Maiava Leads Trojans Against Bucks

Updated on 10/26/26

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The Ohio State Buckeyes will take on the USC Trojans in this week's college football action. Kickoff is set for 7:30 p.m. EST at Los Angeles Memorial Coliseum in Los Angeles, CA. The game will be broadcast live on NBC. Here's everything you need to know about Ohio State vs. USC odds, the latest college football spreads, college football over/unders and more.

OSU @ USC Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 4Q
  • 3Q
  • Spread
  • Total
  • Moneyline
Ohio State Buckeyes 189 Ohio State
-7.5 -110 -3.5 -108 + N/A -3.5 -108 + -3.5 -113 + -3.5 -105 + N/A -3.5 -115 + N/A -6.5 -115  
USC Trojans 190 USC
+7.5 -110 +3.5 -112 + N/A +3.5 -112 + +3.5 -109 + +3.5 -115 + N/A +3.5 -115 + N/A +6.5 -105  
Ohio State Buckeyes 189 Ohio State
o55.5 -102 o26.5 -114 + N/A o25.5 -112 + o26.5 -106 + o26.5 -115 + N/A o26.5 -115 + N/A o51.5 -108  
USC Trojans 190 USC
u55.5 -118 u26.5 -106 + N/A u25.5 -108 + u26.5 -115 + u26.5 -105 + N/A u26.5 -115 + N/A u51.5 -112  
Ohio State Buckeyes 189 Ohio State
-310 N/A N/A N/A N/A N/A N/A N/A +1011 + -250  
USC Trojans 190 USC
+250 N/A N/A N/A N/A N/A N/A N/A -138 + +205  
Ohio State Buckeyes 189 Ohio State
-7.5 -110 N/A N/A -0.5 +105 + N/A -1.5 +114 + N/A -0.5 even + N/A -6.5 -115  
USC Trojans 190 USC
+7.5 -110 N/A N/A +0.5 -135 + N/A +1.5 -138 + N/A +0.5 -135 + N/A +6.5 -105  
Ohio State Buckeyes 189 Ohio State
o55.5 -102 N/A N/A o10.5 +110 + N/A o10.5 +106 + N/A o10.5 even + N/A o51.5 -108  
USC Trojans 190 USC
u55.5 -118 N/A N/A u10.5 -140 + N/A u10.5 -128 + N/A u10.5 -135 + N/A u51.5 -112  
Ohio State Buckeyes 189 Ohio State
-310 N/A N/A -160 + N/A -144 + N/A N/A N/A -250  
USC Trojans 190 USC
+250 N/A N/A +124 + N/A +122 + N/A N/A N/A +205  
Ohio State Buckeyes 189 Ohio State
-7.5 -110 N/A N/A N/A N/A -2.5 -110 + N/A N/A N/A -6.5 -115  
USC Trojans 190 USC
+7.5 -110 N/A N/A N/A N/A +2.5 -110 + N/A N/A N/A +6.5 -105  
Ohio State Buckeyes 189 Ohio State
o55.5 -102 N/A N/A N/A N/A o14.5 -102 + N/A N/A N/A o51.5 -108  
USC Trojans 190 USC
u55.5 -118 N/A N/A N/A N/A u14.5 -118 + N/A N/A N/A u51.5 -112  
Ohio State Buckeyes 189 Ohio State
-310 N/A N/A N/A N/A -166 + N/A N/A N/A -250  
USC Trojans 190 USC
+250 N/A N/A N/A N/A +140 + N/A N/A N/A +205  
Ohio State Buckeyes 189 Ohio State
-7.5 -110 N/A N/A N/A N/A -1.5 +104 + N/A N/A N/A -6.5 -115  
USC Trojans 190 USC
+7.5 -110 N/A N/A N/A N/A +1.5 -126 + N/A N/A N/A +6.5 -105  
Ohio State Buckeyes 189 Ohio State
o55.5 -102 N/A N/A N/A N/A o13.5 -118 + N/A N/A N/A o51.5 -108  
USC Trojans 190 USC
u55.5 -118 N/A N/A N/A N/A u13.5 -104 + N/A N/A N/A u51.5 -112  
Ohio State Buckeyes 189 Ohio State
-310 N/A N/A N/A N/A -152 + N/A N/A N/A -250  
USC Trojans 190 USC
+250 N/A N/A N/A N/A +130 + N/A N/A N/A +205  
Ohio State Buckeyes 189 Ohio State
-7.5 -110 N/A N/A N/A N/A -2.5 -110 + N/A N/A N/A -6.5 -115  
USC Trojans 190 USC
+7.5 -110 N/A N/A N/A N/A +2.5 -110 + N/A N/A N/A +6.5 -105  
Ohio State Buckeyes 189 Ohio State
o55.5 -102 N/A N/A N/A N/A o10.5 -104 + N/A N/A N/A o51.5 -108  
USC Trojans 190 USC
u55.5 -118 N/A N/A N/A N/A u10.5 -116 + N/A N/A N/A u51.5 -112  
Ohio State Buckeyes 189 Ohio State
-310 N/A N/A N/A N/A -215 + N/A N/A N/A -250  
USC Trojans 190 USC
+250 N/A N/A N/A N/A +164 + N/A N/A N/A +205  

The Ohio State Buckeyes opened as a -7 point favorite over USC. The total is set at over/under 51.5 total points scored by both teams combined.

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Updated on 10/26/26

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Ohio State vs. USC Prediction

This line is baffling if this is the Luke Fahey line. I know this USC defense has not been strong, but they will be home after a loss to Wisconsin and they will clearly be fired up. This USC offense is one of the most exciting in college football, ranking in the 96th percentile for success rate and in the 97th percentile for pass success rate.

This Ohio State defense is good, but they aren't as strong as last year's unit. Maiava should be able to pick apart this defense and beat Ohio State in a track meet, especially if they start a backup QB.

Ohio State vs. USC Prediction: USC Trojans +7 (-112)

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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