NFL Week 12 Odds: Lines, Spreads, Betting Trends for All 14 Games

Patrick Everson Sports Betting Expert

10 minute read

2025 NFL Week 12 Odds

NFL Week 12 odds serve up a few key clashes, including one in which the defending AFC champs find themselves in a must-win situation.

Indianapolis Colts vs. Kansas City Chiefs is the most intriguing matchup in the NFL odds Week 12 market. In the NFC, Tampa Bay Buccaneers vs. Los Angeles Rams and Philadelphia Eagles vs. Dallas Cowboys are noteworthy, too.

Here’s everything you need to know about NFL odds Week 12: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on Week 12 NFL odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Charles LeClaire/Imagn Images)

2025 NFL Odds for Week 12

Buffalo Bills vs. Houston Texans Odds

• Opening point spread: Bills -3.5
• Opening moneyline: Bills TBA/Texans TBA
• Opening total: Over/Under 43.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

OPENING ODDS UPDATE: Buffalo (7-3 SU/5-5 ATS) got all it could handle from Tampa Bay before pulling away late in Week 11. The Bills trailed 32-31 early in the fourth quarter, but scored followed with two TDs in a 44-32 victory laying 6.5 points at home.

Houston (5-5 SU and ATS) didn't exactly light it up behind backup QB Davis Mills against one-win Tennessee. But the Texans escaped with a 16-13 victory on a final-seconds field goal, while failing to cover as 5.5-point road favorites.

In the NFL odds Week 12 market, The SuperBook opened Buffalo beyond a field-goal road favorite.

"This one moved from the lookahead number of Bills -2.5 (-120) through the key number of 3, and now is at Buffalo -3.5," SuperBook vice president John Murray said Sunday night. "The public will be on the Bills.

"This is exactly the type of game the public loves: A short road favorite that scores a lot of points. We’ll need Houston."

Indianapolis Colts vs. Kansas City Chiefs Odds

• Opening point spread: Chiefs -3.5
• Opening moneyline: Chiefs TBA/Colts TBA
• Opening total: Over/Under 49.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Kansas City entered Week 11 still sitting atop Super Bowl odds, despite a 5-4 SU and ATS record. Not any more, after falling to .500. The Chiefs (5-5 SU and ATS) lost to Denver 22-19 as 4-point road favorites.

Indianapolis (8-2 SU/6-4 ATS) is coming off its bye week, after a long road trip to Berlin, Germany, in Week 10. The Colts barely weathered Atlanta, winning 31-25 in overtime as 6.5-point favorites on the strength of three Jonathan Taylor touchdowns, including the game winner.

For Colts-Chiefs, The SuperBook once again used its lookahead line for some guidance in NFL Week 12 odds.

"The lookahead on this game was Kansas City -4.5. The combination of money on the Colts and the Chiefs losing again on Sunday caused us to move it down a point to Chiefs -3.5, where it sits currently," SuperBook VP John Murray said.

Pittsburgh Steelers vs. Chicago Bears Odds

• Opening point spread: Bears -2.5
• Opening moneyline: Bears TBA/Steelers TBA
• Opening total: Over/Under 44.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Chicago is already out to a surprising 7-3 SU and ATS. In Week 11, the Bears were 2.5-point 'dogs at Minnesota and won 19-17 on a field goal as time expired. Chicago has won three in a row and is 7-1 SU/6-2 ATS in its last eight games.

Pittsburgh (6-4 SU/5-5 ATS) halted a 1-3 SU and ATS skid in Week 11. The Steelers rolled over Cincinnati 34-12 giving 5.5 points at home.

The SuperBook opened Steelers-Bears at Chicago -2.5 (-120) Sunday evening and got to -3 even in short order. Later Sunday night, the Bears went to -3 flat.

"These are two teams that I cannot decide if they are good or not. But they both seem to keep winning," SuperBook VP John Murray said.

Minnesota Vikings vs. Green Bay Packers Odds

• Opening point spread: Packers -5.5
• Opening moneyline: Packers TBA/Vikings TBA
• Opening total: Over/Under 43 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Green Bay (6-3-1 SU/3-7 ATS) halted a two-game losing hiccup, but failed to cash for the third straight week and seventh game in the last eight outings. The Packers fended off the New York Giants 27-20 as 7.5-point road favorites.

Green Bay QB Jordan Love exited in the first half with a left shoulder injury, but returned to throw two TD passes.

Minnesota (4-6 SU and ATS) now has twice as many losses as it had all of last regular season. In Week 11, the Vikings got a Jordan Addison touchdown to go up 17-16 with 50 seconds left vs. Chicago. But the Vikes tumbled 19-17 on a final-seconds field goal.

Green Bay opened as 5.5-point home chalk vs. Minnesota and quickly advanced to -6 in The SuperBook's NFL Week 12 odds.

"The Packers won ugly today. But we know the public will be on them next week," SuperBook VP John Murray said Sunday night.

The total was more on the move, going from 43 to 42.5/42.

New York Giants vs. Detroit Lions Odds

• Opening point spread: Lions -10.5
• Opening moneyline: Lions TBA/Giants TBA
• Opening total: Over/Under 49 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Detroit (6-3 SU and ATS) is right in the middle of its Week 11 assignment. The Lions are facing Philadelphia on Sunday Night Football.

New York (2-9 SU/6-5 ATS), minus starting QB Jaxson Dart, hung in with Jameis Winston vs. Green Bay in Week 11. But the Giants came up short 27-20, while covering as 7.5-point home 'dogs.

The SuperBook opened Giants-Lions at Detroit -10.5, then took the game off the board once Lions-Eagles kicked off. Giants-Lions will go back up Monday morning.

New England Patriots vs. Cincinnati Bengals Odds

• Opening point spread: Patriots -5.5
• Opening moneyline: Patriots TBA/Bengals TBA
• Opening total: Over/Under 50.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: New England (9-2 SU/8-3 ATS) kept rolling in the Week 11 Thursday night game. The Patriots topped the Jets 27-14, narrowly covering as 12.5-point home favorites. Drake Maye & Co. are on an 8-0 SU/7-1 ATS spree.

Cincinnati (3-7 SU and ATS) hung around into the third quarter at Pittsburgh. But the Bengals put up only a field goal in the second half and lost 34-12 catching 5.5 points.

New England opened -5.5 in The SuperBook's NFL odds Week 12 market and advanced to -6.5 in short order Sunday night.

New York Jets vs. Baltimore Ravens Odds

• Opening point spread: Ravens -14
• Opening moneyline: Ravens TBA/Jets TBA
• Opening total: Over/Under 44.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Baltimore (5-5 SU/4-6 ATS) has made its way back to .500, after a 1-5 start. In Week 11, the Ravens got more of a challenge than expected at Cleveland, trailing 13-3 in the second quarter.

But Lamar Jackson & Co. ultimately prevailed 23-16, with a Mark Andrews TD catch with 2:31 left snapping a 16-16 tie. Baltimore fell just short of covering as 7.5-point chalk, but is 4-0 SU/3-1 ATS in its last four outings.

New York (2-8 SU/4-6 ATS) saw its modest two-game win streak end in Week 11. The Jets couldn't keep pace at New England, losing 27-14 as 12.5-point underdogs.

Jets-Ravens opened at Baltimore -14 in The SuperBook's Week 12 NFL odds, with no movement Sunday night.

Seattle Seahawks vs. Tennessee Titans Odds

• Opening point spread: Seahawks -13
• Opening moneyline: Seahawks TBA/Titans TBA
• Opening total: Over/Under 42 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Seattle (7-3 SU/8-2 ATS) saw its four-game win streak end, but managed to cover for the fifth straight game, even though Sam Darnold threw four interceptions. The Seahawks fell just short to the L.A. Rams 21-19 getting 3 points on the road.

Tennessee (1-9 SU/4-6 ATS) made things interesting late vs. Houston, getting a Van Jefferson TD to tie at 13 with 1:35 remaining. But the Titans ultimately fell 16-13 on a field goal as time expired, while covering as 5.5-point home pups.

Seahawks-Titans saw an early move Sunday night at The SuperBook, from Seattle -13 to -12.5. The total nudged from 42 to 41.5.

Jacksonville Jaguars vs. Arizona Cardinals

• Opening point spread: Jaguars -2.5
• Opening moneyline: Jaguars TBA/Cardinals TBA
• Opening total: Over/Under 46 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Arizona (3-7 SU/5-5 ATS) is on a 1-8 SU freefall heading to Week 12. The Cardinals were never really in it vs. San Francisco, trailing by 25 multiple times in a 41-22 loss as 3.5-point home underdogs.

Jacksonville (6-4 SU and ATS) halted a 1-3 SU/0-3-1 ATS skid in Week 12, and in convincing fashion. The Jaguars torched the L.A. Chargers 35-6 getting 3 points at home.

Jacksonville opened -2.5 vs. Arizona in The SuperBook's NFL Week 12 odds, with no early movement.

Cleveland Browns vs. Las Vegas Raiders Odds

• Opening point spread: Raiders -3
• Opening moneyline: Raiders TBA/Browns TBA
• Opening total: Over/Under 38 points scored
• Time: 4:05 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Las Vegas (2-7 SU/4-5 ATS) still has Week 11 work to do. The Raiders host Dallas on Monday Night Football.

Cleveland (2-8 SU/4-6 ATS) gave Baltimore a better challenge than expected in Week 11. But with the game tied at 16, the Browns gave up a late touchdown and couldn't respond with their own, losing 23-16 as 7.5-point home underdogs.

The SuperBook opened Las Vegas as 3-point home chalk, with no movement Sunday night.

Philadelphia Eagles vs. Dallas Cowboys Odds

• Opening point spread: Eagles -4.5
• Opening moneyline: Eagles TBA/Cowboys TBA
• Opening total: Over/Under 50.5 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Philadelphia (7-2 SU/6-3 ATS) is in the midst of its Week 11 game, hosting Detroit on Sunday Night Football.

Dallas (3-5-1 SU/4-5 ATS) also has Week 11 work to do, traveling to Las Vegas for the Monday night game.

Still, The SuperBook opened Eagles-Cowboys at Philly -4.5 in the NFL odds Week 12 market. The game came off the board once Lions-Eagles kicked off, and it will go back up Monday morning.

"We didn’t see much betting on the side before it came down. But there was sharp money on Over 50.5. I get it. It’s always hard to picture Dallas stopping anyone," SuperBook vice president John Murray said.

Atlanta Falcons vs. New Orleans Odds

• Opening point spread: Falcons -3
• Opening moneyline: Falcons TBA/Saints TBA
• Opening total: Over/Under 40 points scored
• Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Atlanta was 3-2 SU and ATS through five games and coming off a big upset of Buffalo. The Falcons haven't won since, now 3-7 SU and ATS.

In Week 11, Atlanta blew a 21-7 first-half lead and ultimately lost 30-27 in overtime as 4.5-point home chalk vs. Carolina.

New Orleans (1-8 SU/2-7 ATS) had its bye in Week 11, after an upset win in Week 10. The Saints were 5.5-point pups at Carolina and won 17-7, halting an 0-4 SU and ATS slide.

The SuperBook opened the Falcons -3 vs. the Saints in Week 12 NFL odds. The first move came shortly thereafter, to Falcons -2.5.

Tampa Bay Buccaneers vs. Los Angeles Rams Odds

• Opening point spread: Rams -6.5
• Opening moneyline: Rams TBA/Buccaneers TBA
• Opening total: Over/Under 49.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

OPENING ODDS UPDATE: Los Angeles (8-2 SU and ATS) forced Sam Darnold into four interceptions and needed all of them, barely hanging on vs. Seattle in Week 11. The Rams notched a 21-19 victory laying 3 points at home, their fifth consecutive SU win (4-1 ATS).

After a 5-1 SU start, Tampa Bay dumped three of its last four games, falling back to 6-4 SU/5-5 ATS. In Week 11, the Bucs led at Buffalo 32-31 early in the fourth quarter, but couldn't keep it up in a 44-32 loss as 6.5-point underdogs.

L.A. opened as 6.5-point home chalk in The SuperBook's NFL Week 12 odds.

"We haven’t seen much business yet. But we expect a lot of parlays to close with Rams and Rams moneyline next Sunday night," SuperBook VP John Murray said.

Carolina Panthers vs. San Francisco 49ers Odds

• Opening point spread: 49ers -6.5
• Opening moneyline: 49ers TBA/Panthers TBA
• Opening total: Over/Under 46.5 points scored
• Time: 8:15 p.m. ET Monday (ABC/ESPN)

OPENING ODDS UPDATE: San Francisco (7-4 SU and ATS) got Brock Purdy back in the fold in Week 11, and he delivered. Purdy threw three touchdown passes, and the Niners thumped Arizona 41-22 as 3.5-point road favorites.

Carolina (6-5 SU/7-4 ATS) is among the surprise teams this season, above .500 heading to Week 12. In Week 11, the Panthers overcame a 21-7 first-half deficit to upset Atlanta 30-27 in overtime as 4.5-point road underdogs.

On Sunday night, Panthers-49ers opened at San Fran -6.5 in The SuperBook's NFL odds Week 12 market.

"We have seen a lot of money on San Francisco on this game in the lookahead market. They bet us from -5.5 to -6, and now we are at -6.5," SuperBook VP John Murray said. "The parlays that get through Sunday afternoon and the Rams will go to the 49ers next Monday night."

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson