Oregon vs. USC Prediction: Oregon Wins This Big-Ten Showdown

Dylan Wilkerson Sports Betting Expert

14 minute read

Updated on 10/12/26

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The Oregon Ducks will take on the USC Trojans in this week's college football action. Kickoff is set for 7:30p.m. EST at Los Angeles Memorial Coliseum in Los Angeles, CA. The game will be broadcast live on NBS. Here's everything you need to know about Oregon vs. USC odds, the latest college football spreads, college football over/unders and more.

Oregon @ USC Betting Odds

• Spread
• Total
• Moneyline

Time	Open	Bet365	BetMGM	DraftKings	Caesars	FanDuel	HardRock	Fanatics	RiversCasino	Consensus
Final	Open	›	›	›	›	›	›	›	›
399 Oregon	-5.5 -110	-3.5 -105	-3.5 -108	-3.5 -110	-3.5 -114	-3.5 -110	-5.5 -115	-3.5 -115	-3.5 -110	-3.5 -110
400 USC	+5.5 -110	+3.5 -115	+3.5 -110	+3.5 -110	+3.5 -114	+3.5 -110	+5.5 -105	+3.5 -105	+3.5 -113	+3.5 -110
Matchup
Final	Open	›	›	›	›	›	›	›	›
399 Oregon	o58.5 -108	o60.5 -105	o60.5 -110	o60.5 -110	o60.5 -114	o61.5 -110	N/A	o60.5 -110	o61 -113	o60.5 -110
400 USC	u58.5 -112	u60.5 -115	u60.5 -108	u60.5 -110	u60.5 -114	u61.5 -110	N/A	u60.5 -110	u61 -109	u60.5 -110
Matchup
Final	Open	›	›	›	›	›	›	›	›
399 Oregon	-238	-180	-185	-185	-195	-172	-240	-190	-177	-185
400 USC	+195	+150	+150	+154	+150	+142	+185	+155	+143	+154
Matchup

The Oregon Ducks opened as a -2.5 point favorite over USC. The total is set at over/under 62.5 total points scored by both teams combined.

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Updated on 10/12/26

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Oregon vs. USC Prediction

USC is not coming into this game in the best of spots. That had one of the biggest travel sessions last week when they headed to Rutgers and looked sleepy off of the plane. Now they return from their trip and prepare for an Oregon team that has a very small margin of error. If motivation is a factor, Oregon has the motivation.

Despite having a loss, Oregon ranks out very well in power rankings. I think Oregon takes this matchup.

Oregon vs. USC Prediction: Oregon -2.5

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson