Oregon vs. USC Prediction: Oregon Wins This Big-Ten Showdown

Dylan Wilkerson Sports Betting Expert

14 minute read

Updated on 9/22/26

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The Oregon Ducks will take on the USC Trojans in this week's college football action. Kickoff is set for 7:30p.m. EST at Los Angeles Memorial Coliseum in Los Angeles, CA. The game will be broadcast live on NBS. Here's everything you need to know about Oregon vs. USC odds, the latest college football spreads, college football over/unders and more.

Oregon @ USC Betting Odds

• Spread
• Total
• Moneyline

Time	Open	Bet365	BetMGM	DraftKings	Caesars	FanDuel	HardRock	Fanatics	RiversCasino	Consensus
	Open	›	›	›	›	›	›	›	›
399 Oregon	-5.5 -110	-3 -110	-3 -112	-3 -112	-3 -112	-2.5 -124	-5.5 -115	-3 -110	-3 -115	-3 -112
400 USC	+5.5 -110	+3 -110	+3 -105	+3 -108	+3 -109	+2.5 +102	+5.5 -105	+3 -110	+3 -108	+3 -108
Matchup
	Open	›	›	›	›	›	›	›	›
399 Oregon	o58.5 -108	o62.5 -105	o61.5 -112	o62.5 -108	o62.5 -110	o61.5 -115	N/A	o62 -110	o63 -109	o62.5 -108
400 USC	u58.5 -112	u62.5 -115	u61.5 -105	u62.5 -112	u62.5 -109	u61.5 -105	N/A	u62 -110	u63 -113	u62.5 -112
Matchup
	Open	›	›	›	›	›	›	›	›
399 Oregon	-238	-160	-165	-162	-165	-152	-240	-160	-159	-162
400 USC	+195	+135	+138	+136	+135	+126	+185	+135	+125	+136
Matchup

The Oregon Ducks opened as a -2.5 point favorite over USC. The total is set at over/under 62.5 total points scored by both teams combined.

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Updated on 9/22/26

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Oregon vs. USC Prediction

USC is not coming into this game in the best of spots. That had one of the biggest travel sessions last week when they headed to Rutgers and looked sleepy off of the plane. Now they return from their trip and prepare for an Oregon team that has a very small margin of error. If motivation is a factor, Oregon has the motivation.

Despite having a loss, Oregon ranks out very well in power rankings. I think Oregon takes this matchup.

Oregon vs. USC Prediction: Oregon -2.5

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson