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Oregon vs. USC Prediction: Oregon Wins This Big-Ten Showdown

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
14 minute read
Oregon vs. USC Prediction: Oregon Wins This Big-Ten Showdown

Updated on 11/7/26

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The Oregon Ducks will take on the USC Trojans in this week's college football action. Kickoff is set for 7:30p.m. EST at Los Angeles Memorial Coliseum in Los Angeles, CA. The game will be broadcast live on NBS. Here's everything you need to know about Oregon vs. USC odds, the latest college football spreads, college football over/unders and more.

ORE @ USC Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
Oregon Ducks 399 Oregon
-5.5 -110 -1.5 -115 -0.5 -102 -1.5 -108 -2.5 -112 -1.5 -110 N/A -2.5 -115 -3.5 -110  
USC Trojans 400 USC
+5.5 -110 +1.5 -105 +0.5 -118 +1.5 -112 +2.5 -117 +1.5 -110 N/A +2.5 -115 +3.5 -110  
Final
Oregon Ducks 399 Oregon
o58.5 -108 o30.5 -120 o30.5 -118 o30.5 -125 o30.5 -122 o30.5 -118 N/A o31.5 +105 o60.5 -110  
USC Trojans 400 USC
u58.5 -112 u30.5 even u30.5 -102 u30.5 +105 u30.5 -105 u30.5 -104 N/A u31.5 -140 u60.5 -110  
Final
Oregon Ducks 399 Oregon
-238 -130 -118 -142 -139 -148 N/A N/A -185  
USC Trojans 400 USC
+195 +110 -102 +120 +106 +122 N/A N/A +154  
Final
Oregon Ducks 399 Oregon
-5.5 -110 -0.5 +145 +0.5 -135 -0.5 +135 N/A -1.5 +134 N/A -0.5 +125 -3.5 -110  
USC Trojans 400 USC
+5.5 -110 +0.5 -185 -0.5 +105 +0.5 -175 N/A +1.5 -166 N/A +0.5 -170 +3.5 -110  
Final
Oregon Ducks 399 Oregon
o58.5 -108 o13.5 -160 o13.5 -145 o13.5 -154 N/A o13.5 -136 N/A o14.5 +145 o60.5 -110  
USC Trojans 400 USC
u58.5 -112 u13.5 +125 u13.5 +110 u13.5 +120 N/A u13.5 +110 N/A u14.5 -205 u60.5 -110  
Final
Oregon Ducks 399 Oregon
-238 -120 +115 -135 N/A -116 N/A N/A -185  
USC Trojans 400 USC
+195 -110 -145 +105 N/A -100 N/A N/A +154  
Final
Oregon Ducks 399 Oregon
-5.5 -110 N/A N/A -2.5 -108 N/A N/A N/A N/A -3.5 -110  
USC Trojans 400 USC
+5.5 -110 N/A N/A +2.5 -112 N/A N/A N/A N/A +3.5 -110  
Final
Oregon Ducks 399 Oregon
o58.5 -108 N/A N/A o28.5 -112 N/A N/A N/A N/A o60.5 -110  
USC Trojans 400 USC
u58.5 -112 N/A N/A u28.5 -108 N/A N/A N/A N/A u60.5 -110  
Final
Oregon Ducks 399 Oregon
-238 N/A N/A -155 N/A N/A N/A N/A -185  
USC Trojans 400 USC
+195 N/A N/A +130 N/A N/A N/A N/A +154  
Final
Oregon Ducks 399 Oregon
-5.5 -110 N/A N/A -1.5 -115 N/A -1.5 -100 N/A N/A -3.5 -110  
USC Trojans 400 USC
+5.5 -110 N/A N/A +1.5 -115 N/A +1.5 -122 N/A N/A +3.5 -110  
Final
Oregon Ducks 399 Oregon
o58.5 -108 o17.5 -115 N/A o16.5 -125 N/A o17.5 +106 N/A N/A o60.5 -110  
USC Trojans 400 USC
u58.5 -112 u17.5 -125 N/A u16.5 -105 N/A u17.5 -130 N/A N/A u60.5 -110  
Final
Oregon Ducks 399 Oregon
-238 -200 N/A -145 N/A -146 N/A N/A -185  
USC Trojans 400 USC
+195 +150 N/A +114 N/A +124 N/A N/A +154  
Final
Oregon Ducks 399 Oregon
-5.5 -110 N/A N/A -0.5 +105 N/A -1.5 +102 N/A N/A -3.5 -110  
USC Trojans 400 USC
+5.5 -110 N/A N/A +0.5 -135 N/A +1.5 -124 N/A N/A +3.5 -110  
Final
Oregon Ducks 399 Oregon
o58.5 -108 o14 -105 N/A o13.5 -115 N/A o13.5 -128 N/A N/A o60.5 -110  
USC Trojans 400 USC
u58.5 -112 u14 -135 N/A u13.5 -115 N/A u13.5 +106 N/A N/A u60.5 -110  
Final
Oregon Ducks 399 Oregon
-238 -220 N/A -154 N/A -172 N/A N/A -185  
USC Trojans 400 USC
+195 +160 N/A +120 N/A +134 N/A N/A +154  
Final
Oregon Ducks 399 Oregon
-5.5 -110 -2 -120 N/A -0.5 +110 N/A -1.5 +130 N/A N/A -3.5 -110  
USC Trojans 400 USC
+5.5 -110 +2 -120 N/A +0.5 -140 N/A +1.5 -160 N/A N/A +3.5 -110  
Final
Oregon Ducks 399 Oregon
o58.5 -108 o17 -120 N/A o16.5 -115 N/A o15.5 -106 N/A N/A o60.5 -110  
USC Trojans 400 USC
u58.5 -112 u17 -120 N/A u16.5 -115 N/A u15.5 -116 N/A N/A u60.5 -110  
Final
Oregon Ducks 399 Oregon
-238 -190 N/A -125 N/A -120 N/A N/A -185  
USC Trojans 400 USC
+195 +140 N/A -105 N/A +102 N/A N/A +154  

The Oregon Ducks opened as a -2.5 point favorite over USC. The total is set at over/under 62.5 total points scored by both teams combined.

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Updated on 11/7/26

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Oregon vs. USC Prediction

USC is not coming into this game in the best of spots. That had one of the biggest travel sessions last week when they headed to Rutgers and looked sleepy off of the plane. Now they return from their trip and prepare for an Oregon team that has a very small margin of error. If motivation is a factor, Oregon has the motivation.

Despite having a loss, Oregon ranks out very well in power rankings. I think Oregon takes this matchup.

bet oregon spread now

Oregon vs. USC Prediction: Oregon -2.5

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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