2022 Clemson Tigers Betting Odds, Picks & Predictions


The Clemson Tigers saw a six-year run of making the College Football Playoff end last season. It all started with a lackluster 10-3 loss on a neutral-field site against eventual national champ Georgia, and the final nails were driven into the coffin by NC State in Raleigh on Sept. 25, and then at Pittsburgh on Oct. 23. Two conference losses for the Tigers is unheard of in recent years, and Wake Forest even represented the Atlantic Division in the ACC Championship Game, ending Clemson's reign of terror in the league title game, too.

QB DJ Uiagalelei wasn't quite up to snuff in 2021, as the offense was stagnant at times under his leadership. In fact, he completed just 54.7% of his passes for 2,059 yards, nine touchdowns and nine interceptions in 12 regular-season games, while running for 296 yards and four scores. The Tigers averaged just 191.5 passing yards per game to rank 103rd in the nation, while scoring just 26.8 PPG to rank 79th. If not for a hellish defense bailing this team out, it would have had even more losses. If Uiagalelei continues to make big-time mistakes, five-star freshman Cade Klubnik could be the next big thing.

Clemson has a nice stable of tailbacks returning, as Will Shipley (131-678-10), Kobe Pace (92-590-6) and Phil Mafah (66-285-3) all return. They will run behind an offensive line which needs improvement, but has four starters coming back.

TE Davis Allen (26-199-3) showed some signs of life last season, and if he takes a big step forward he could be the next great Clemson tight end like former Indianapolis Colts standout Dwayne Allen, no relation. WRs Beau Collins (28-387-3) and Joseph Ngata (23-438-1) are also back, hoping to continue building rapport with Uiagalelei.

Defensively, this Tigers unit should be stout again. While defensive coordinator Brent Venables moved to the University of Oklahoma to become the head coach, he leaves this team in good hands. Defensive Coordinator Wes Goodwin takes over, and Clemson has an embarrassment of riches on D. DTs Bryan Bresee and Tyler Davis are studs up front, and DEs K.J. Henry, Justin Mascoll, Myles Murphy and Xavier Thomas will each rotate in and work to give opposing quarterbacks and offensive coordinators headaches.

The team has some question marks in the back end of the defense after losing three starters, but they tend to reload and move on at Clemson. The newbs should be just fine. The non-conference scheduled doesn't look terribly daunting at all, and only road trips to Wake Forest and Notre Dame are likely to give the Tigers trouble. A home date against NC State in early October is a calendar circler, too. This has the look of a 10- or 11-win regular season, and perhaps a return to the CFP.

Best Bet: Clemson Over 10.5 Wins (-130)

Updated on 04/21/2024
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  • Mon., Sept. 5 - vs. Georgia Tech*
  • Sat., Sept. 10 - vs. Furman
  • Sat., Sept. 17 - vs. Louisiana Tech
  • Sat., Sept. 24 - at Wake Forest
  • Sat., Oct. 1 - vs. NC State
  • Sat., Oct. 8 - at Boston College
  • Sat., Oct. 15 - at FSU
  • Sat., Oct. 22 - vs. Syracuse
  • Sat., Nov. 5 - at Notre Dame
  • Sat., Nov. 12 - vs. Louisville
  • Sat., Nov. 19 - vs. Miami-Florida
  • Sat., Nov. 26 - vs. South Carolina


  • Over 10.5 (-130)
  • Under 10.5 (+100)



While Wake Forest and NC State could potentially rise up and spoil Clemson's season yet again, it's unlikely Dabo Swinney's group remembers last season, and it has a long memory. They'll use last season's disappointment for motivation, and I think they'll wear it well. The schedule isn't terribly daunting at all, and one of the two difficult conference games against NC State will be in Death Valley.

Clemson should march to the ACC title game and win it. There just doesn't appear to be a lot standing in the way, other than the lack of development from Uiagalelei. If he falters, there is a backup plan now. Clemson wins the ACC title game and goes back to the CFP. Book it.



The Tigers were a tremendous national title contender for years, but I don't think we can quite vault them to the top of the heap just yet unless Uiagalelei takes a giant step forward. He entered last season with Heisman hype, but everywhere you turn there is criticism this season. Perhaps he uses that as fuel, and helps this team go on a serious run. I think a CFP appearance and semifinal loss is the ceiling for Clemson. Don't bet on another national title.

QB D.J. Uiagalelei needs to take a big step forward in 2022. (Getty Images)


D.J. Uiagalelei (QB) +2000

Will Shipley (RB) +6600

Kobe Pace (RB) +10000

Joseph Ngata (WR) +10000

Beaux Collins (WR) +20000

Bryan Breese (DT) +20000

The only realistic Heisman candidate on this list is Uiagalelei, if he can develop, make better decisions and knock off the miscues. If not, he could be this season's Spencer Rattler, entering the season with Heisman hopes, while ending the season on the bench and perhaps to the transfer portal. There is very little reason to bet on a quarterback who had more INTs than TDs last season.


  • SU: 10-3
  • ATS: 5-8
  • O/U: 5-8
  • ATS-Home: 2-5
  • ATS-Road: 3-3
  • ATS-Favorite: 5-7
  • ATS-Underdog: 0-1