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2021 Clemson Tigers Football Betting Predictions

June 15, 2021
by Joe Williams

2021 Clemson Tigers Betting Odds, Predictions, Preview

The Clemson Tigers lost against Ohio State in the CFP Semifinals by a 49-28 score, suffering a second loss. By Clemson’s standards, that was a failure. That’s how high head coach Dabo Swinney has set to the bar in the upstate.

The Tigers have to replace QB Trevor Lawrence, who now plies his trade with the Jacksonville Jaguars. The offense must also replace the likes of RB Trevor Etienne, who joins the signal caller in Northeast Florida. That’s three straight NFL Drafts with two Tigers players going in the first round, one year short of the school record for four straight drafts from 2014-17.

Head coach Dabo Swinney has produced 69 total draft picks since the 2009 NFL Draft, behind only Alabama’s Nick Saban. Despite that high turnover, the Tigers just keep reloading. Clemson has 10 consecutive seasons with 10 or more victories, and there is high confidence that an 11th straight double- digit win season is in the offing.

Looking ahead at Clemson’s schedule, they get a neutral-site game at Bank of America Stadium on Sept. 4 against Georgia to kick off the season. After a tune-up game against FCS South Carolina State on Sept. 11, they host Georgia Tech in the ACC opener.

Preseason Best Bet: Over 11.5 Wins +100

2021 Clemson Tigers Schedule

  • 09/04/2021 - vs. Georgia
  • 09/11/2021 - vs. South Carolina State
  • 09/18/2021 - vs. Georgia Tech
  • 09/25/2021 - at N.C. State
  • 10/02/2021 - vs. Boston College
  • 10/15/2021 - at Syracuse
  • 10/23/2021 - at Pittsburgh
  • 10/30/2021 - vs. FSU
  • 11/06/2021 - at Louisville
  • 11/13/2021 - vs. UConn
  • 11/20/2021 - vs. Wake Forest
  • 11/27/2021 - at South Carolina

Win Total Odds

  • Over 11.5 +100
  • Under 11.5 -125


Clemson Odds to win 2021 ACC Championship

Yes -835

They might not face a huge test until their first true road game against North Carolina State, as they have had trouble at Carter-Finley Stadium in Raleigh in the past. I was actually in attendance for one of the biggest shockers, as the No. 7 Tigers were humbled 37-13 by the Wolfpack on Nov. 19, 2011. The game between these two schools is called the Textile Bowl, and the Tigers have won eight straight meetings since that upset in 2011. But there have been near-misses, including a 38-31 Clemson win Nov. 4, 2017, and a 24-17 overtime win Oct. 15, 2016 in Death Valley.

After a home date with Boston College, and a bye week, another potential pitfall might be Friday, Oct. 15 at Syracuse. It’s not that the Orange are expected to be very good. But there’s something about a full house at the Carrier Dome. We saw it from a mediocre Orange team on Oct. 13, 2017, a 27-24 win over then No. 2 Clemson. There was also a near-upset at Death Valley the following year, although the last two meetings have been blood baths.

Trips to Pittsburgh and Louisville sandwich a home with Florida State, a team which should be much better. Wake Forest pays a visit, and then the Tigers wrap up the season on the road against South Carolina. It wouldn’t be surprising to see an undefeated regular season, and great news for the Tigers that neither Miami, North Carolina nor Notre Dame appear on the schedule.

2021 ACC Betting Odds

Clemson Odds to Win 2021-22 College Football Playoff

Yes +300

While we’ve spent a lot of time talking offense, it might be defense which helps this team back into the playoff. Clemson racked up 46 sacks and 14 interceptions in 2020, and the Tigers return every player responsible for those 14 picks, and 45 of the 46 sacks. They were in the Top 20 in scoring defense, and will be there again as well.

Clemson 2021 Heisman Contenders & Odds

D.J. Uiagalelei +700

Justyn Ross +6600

The new starting quarterback D.J. Uiagalelei is a Heisman hopeful. We saw him take the reins of the offense for two games last season when Lawrence was down due to COVID-19. He looked more than capable. Lyn-J Dixon and Will Shipley are also two incoming freshman who will ease the loss of Etienne in the backfield.

Uiagalelei will have a big target on the outside, as Justyn Ross elected to return to school for the 2021 season rather than go pro. Uiagalelei will not have Jackson Carman, a left tackle, keeping the QB upright, but Bryan Bresee and Myles Murphy are potential stars along the O-line.

2021 Heisman Trophy Betting Odds

2020 Clemson Tigers Betting Results

  • 09/12/2020 - Clemson 37 at Wake Forest 13 (+34.5) - Under, 59
  • 09/19/2020 - The Citadel 0 (+50.5) at Clemson 49 - Under, 57
  • 10/03/2020 - Virginia 23 (+28) at Clemson 41 - Over, 55
  • 10/10/2020 - Miami-Florida 17 at Clemson 42 (-14) - Under, 60.5
  • 10/17/2020 - Clemson 73 (-27) at Georgia Tech 7 - Over,65
  • 10/24/2020 - Syracuse 21 (+47.5) at Clemson 47 - Over, 63
  • 10/31/2020 - Boston College 28 (+26.5) at Clemson 34 - Over, 56
  • 11/07/2020 - Clemson 40 at Notre Dame 47 (+4.5) - Over, 51
  • 11/28/2020 - Pittsurgh 17 at Clemson 52 (-24) - Over, 58.5
  • 12/05/2020 - Clemson 45 (-22.5) at Virginia Tech 10 - Under, 66.5
  • 12/19/2020 - Clemson 34 (-10.5) at Notre Dame 10 - Under, 58
  • 01/01/2021 - Ohio State 49 (+7) at Clemson 28 - Over, 68.5
  • SU: 10-2
  • ATS: 5-7
  • O/U: 7-5
  • ATS-Home: 2-5
  • ATS-Road: 3-2
  • ATS-Favorite: 5-7
  • ATS-Underdog: 0-0

Betting on the 2021 Clemson Tigers

Where can I bet on the 2021 Clemson Tigers football team?

There are several legal sportsbook options in the United States. Visit our sportsbook directory to find online sportsbooks where you can bet on the Clemson Tigers.

What other College Football bets are available?

Bets can be placed nearly every team in the FCS. Check out our NCAA Futures Odds to see odds to win the NCAA championship and each conference or visit our main NCAA Football page for the latest betting news.

What’s Clemson's point spreads for each of their games?

College Football odds are generally released early in the week when the game is scheduled to be played. For weekly odds, check out our College Football Vegas Odds page.

Where can I learn how to bet on College Football?

To learn more about betting on College Football, check out our football betting tutorial.

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