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2021 Iowa State Cyclones Football Betting Predictions

June 14, 2021
by Stuart Durst

2021 Iowa State Cyclones Betting Odds, Predictions, Preview

After finishing just short last season, the Cyclones look to set the franchise record with their first 10 win season. With two Heisman candidates, 19 of their 21 starters returning, and three-time Big-12 Coach of the Year Matt Campell coming back, Iowa State has plenty to look forward to.

My preseason best bet is Iowa State to win the Big 12 Championship +225. Deciding between this and over 9.5 wins was incredibly hard, I’m very interested in both. With so much returning talent from last year’s 9-3 season it’s hard to see this team not being a serious contender. Campbell has turned this program into a serious contender, there’s a reason they have nine wins over ranked opponents since 2017.

Preseason Best Bet: Win Big 12 Championship +225

2021 Iowa State Cyclones Schedule

  • 09/04/2021 - vs. UNI
  • 09/11/2021 - vs. Iowa
  • 09/18/2021 - at UNLV
  • 09/25/2021 - at Baylor
  • 10/02/2021 - vs. Kansas
  • 10/16/2021 - ar Kansas State
  • 10/23/2021 - vs. Oklahoma State
  • 10/30/2021 - at West Virginia
  • 11/06/2021 - vs. Texas
  • 11/13/2021 - at Texas Tech
  • 11/20/2021 - at Oklahoma
  • 11/26/2021 - vs. TCU

Win Total Odds

  • Over 9.5 -113
  • Under 9.5 -113


Iowa State Odds to win 2021 Big 12 Championship

Yes +225

I can stress how excited I am for this team, with quarterback Brock Purdy and coach Campbell both turning down extreme NFL interest it’s clear this team has championship desires. The Cyclones also run a ton of 12 personnel, meaning they get to flex their extremely talented tight ends, including Charlie Kolar who is most likely the best tight end in the nation. Purdy will not only have multiple weapons to rely on but they also have an incredibly reliable defense who have limited Oklahoma to their lowest points total in three of the last four seasons.

2021 Big 12 Conference Betting Odds

Iowa State Odds to Win 2021-22 College Football Playoff

Yes +3300

While I’m as high as anyone on the Cyclones I’m personally not super heavy on this one. At +3300 it’s definitely worth a sprinkle but competing against National Championship hopeful Oklahoma is a tough task and they’ll most likely have to do it multiple times. With all the returning talent Iowa as they have a really safe floor of at least 9 wins, I’m just not sure they have the same ceiling as a team like Oklahoma, Alabama, or Clemson.

Iowa State 2021 Heisman Contenders & Odds

Breece Hall +4000

Brock Purdy +5000

Hall is pound for pound one of the best running backs in all of college football. Considering the extremely low percent runningbacks that have won this award over the last 20 years it’s gonna have to be a pass. When running backs are able to climb that enormous mountain and win the Heisman it normally comes playing at schools that dominate the national media, sadly Iowa State does not. Great runningback but not loving the odds at this point in the preseason.

Purdy will most likely hang up the cleats and finish this season as Iowa States’ best quarterback of all time. He’s done incredible things for this program and has been a key to their success during his tenure. That being said, I just don’t think he has the media attention nor flashiness to compete with some of the other guys on this list. He’s a great quarterback who will have another really good season, just don’t think he wins a Heisman for it.

2021 Heisman Trophy Betting Odds

2020 Iowa State Cyclones Betting Results

  • 09/12/2020 - Louisiana 31 (+13) at Iowa State 14 - Under, 56.5
  • 09/26/2020 - Iowa State 37 at TCU 34 (+4.5) - Over, 43
  • 10/03/2020 - Oklahoma 30 at Iowa State 37 (+7.5) - Over, 62.5
  • 10/10/2020 - Texas Tech 15 at Iowa State 31 (-10) - Under, 63
  • 10/24/2020 - Iowa State 21 at Oklahoma State 24 (-2.5) - Under, 54
  • 10/31/2020 - Iowa State 52 (-27.5) at Kansas 22 - Over, 49.5
  • 11/07/2020 - Baylor 31 (+14) at Iowa State 38 - Over, 47
  • 11/21/2020 - Kansas State 0 at Iowa State 45 (-13.5) - Under, 48
  • 11/27/2020 - Iowa State 23 (-1.5) at Texas 20 - Under, 57.5
  • 12/05/2020 - West Virginia 6 at Iowa State 42 (-6) - Push, 48
  • 12/19/2020 - Oklahoma 27 (-5.5) at Iowa State 21 - Under, 59.5
  • 01/02/2021 - Oregon 17 at Iowa State 34 (-4.5) - Under, 57.5
  • SU: 9-3
  • ATS: 7-5
  • O/U: 4-7-1
  • ATS-Home: 5-3
  • ATS-Road: 2-2
  • ATS-Favorite: 6-3
  • ATS-Underdog: 1-2

Betting on the 2021 Iowa State Cyclones

Where can I bet on the 2021 Iowa State Cyclones football team?

There are several legal sportsbook options in the United States. Visit our sportsbook directory to find online sportsbooks where you can bet on the Iowa State Cyclones.

Legal Wagering in Iowa

Iowa Sports Betting is legal, that includes a betting market on college football.

What other College Football bets are available?

Bets can be placed nearly every team in the FCS. Check out our NCAA Futures Odds to see odds to win the NCAA championship and each conference or visit our main NCAA Football page for the latest betting news.

What’s Iowa State's point spreads for each of their games?

College Football odds are generally released early in the week when the game is scheduled to be played. For weekly odds, check out our College Football Vegas Odds page.

Where can I learn how to bet on College Football?

To learn more about betting on College Football, check out our football betting tutorial.

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