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2021 USC Trojans Football Betting Predictions

June 30, 2021
by Joe Williams

2021 USC Trojans Betting Odds, Predictions, Preview

USC looks to defend its South Division crown in 2021, but they're expected to be running neck and neck with Arizona State most of the season.

The hopes of the Trojans are pinned on Heisman hopeful QB Kedon Slovis, but he isn't the only star in the mix in Southern California. RB Keaontay Ingram transfers over from Texas, and WRs K.D. Nixon and Tahj Washington also transfer in, as does TE Malcolm Epps. WR Drake London figures to step up and have a starring role, and true freshman WR Michael Jackson III is also in line for a big role. It's an embarrassment of riches at the skill positions in Los Angeles, but the offensive line play has to be much better, trying to keep their star signal caller upright. That's a huge question mark, as Slovis was dropped 15 times in just six games.

As far as the defensive side of the ball, the Trojans are littered with plenty of NFL prospects. DE Drake Jackson will be playing his football on Sundays in the not-so-distant future, and DE Korey Foreman is a blue-chip prospect joining the mix. Keep an eye on DT Tuli Tuipulotu, who could be a star in the making. S Xavion Alford and CB Chris Thompson transfer in to bolster a secondary which was just middling in 2020.

The USC schedule is rather challenging. It starts with a home date with San Jose State, who is no longer a pushover, and then the conference schedule opens with Stanford at home on Sept. 11, and a trip to Washington State on Sept. 18. That's not exactly easy. A trip to Colorado on Oct. 2 could also be a challenge.

The Trojans also have a marquee road game against traditional rival Notre Dame, and it's conceivable that could have some playoff implications. But the key game, for division title hopes and Pac-12 Championship Game representation, is a trip to Arizona State on Nov. 6. That's going to be a doozy. They also wrap up the season with tough games against UCLA and BYU at home. If they're able to roll through this schedule as perhaps a one-loss team, a playoff spot would be warranted, but there are plenty of pitfalls along the way, and nine or 10 games would still be quite the accomplishment.

Preseason Best Bet: Over 8.5 Wins (+100)

2021 USC Trojans Schedule

  • 09/04/2021 - vs. San Jose State
  • 09/11/2021 - vs. Stanford
  • 09/18/2021 - at Washington State
  • 09/25/2021 - vs. Oregon State
  • 10/02/2021 - at Colorado
  • 10/09/2021 - vs. Utah
  • 10/23/2021 - at Notre Dame
  • 10/30/2021 - vs. Arizona
  • 11/06/2021 - at Arizona State
  • 11/13/2021 - at California
  • 11/20/2021 - vs. UCLA
  • 11/27/2021 - vs. BYU

Win Total Odds

  • Over 8.5 +100
  • Under 8.5 -125


USC Odds to win 2021 Pac-12 Championship

Yes +400

I am buying USC for the South Division title, and I think they could easily be the best team in the league. Their win total is criminally low, and one of my favorite OVER bets. I think they're a very good bet to hoist the conference championship trophy, too, and you can get a return times four? Nice.

2021 Pac-12 Betting Odds

USC Odds to Win 2021-22 College Football Playoff

Yes +5000

It's very possible USC could make an appearance in the CFP, but they'll need to avoid pitfalls in road games to Washington State and Colorado early, and they likely need to top Notre Dame on Oct. 23. Still, the odds are a little long not only to make the CFP, but to win it all? I just don't see the Trojans as a national title contender, although they might be one of the top two or three teams west of the Mississippi River.

USC 2021 Heisman Contenders & Odds

Kedon Slovis +2000

Slovis is going to have plenty of opportunity to roll up some big numbers, as Pac-12 After Dark has garnered a lot of attention in recent seasons. While the East Coast and its voters miss out on a lot of the late-night games, Slovis and the Trojans are in L.A. and will be featured nationally quite a bit. I think the offensive line has to be much better, or Slovis might be dinged up and unable to play all of his games, hurting his chances. I'd pass, but he is one to monitor.

2021 Heisman Trophy Betting Odds

2020 USC Trojans Betting Results

  • 11/07/2020 - Arizona State 27 (+11.5) at USC 28 - Under, 57.5
  • 11/14/2020 - USC 34 at Arizona 30 (+15) - Under, 67.5
  • 11/21/2020 - USC 33 (-1) at Utah 17 - Under, 59
  • 12/06/2020 - Washington State 13 at USC 38 (-11) - Under, 68.5
  • 12/12/2020 - USC 43 (-3.5) at UCLA 38 - Over, 65
  • 12/18/2020 - Oregon 31 (+3) at USC 24 - Under, 65.5
  • SU: 5-1
  • ATS: 3-3
  • O/U: 1-5
  • ATS-Home: 1-2
  • ATS-Road: 2-1
  • ATS-Favorite: 3-3
  • ATS-Underdog: 0-0

Betting on the 2021 USC Trojans

Where can I bet on the 2021 USC Trojans football team?

There are several legal sportsbook options in the United States. Visit our sportsbook directory to find online sportsbooks where you can bet on the USC Trojans.

What other College Football bets are available?

Bets can be placed nearly every team in the FCS. Check out our NCAA Futures Odds to see odds to win the NCAA championship and each conference or visit our main NCAA Football page for the latest betting news.

What’s USC's point spreads for each of their games?

College Football odds are generally released early in the week when the game is scheduled to be played. For weekly odds, check out our College Football Vegas Odds page.

Where can I learn how to bet on College Football?

To learn more about betting on College Football, check out our football betting tutorial.

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