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Featured Last Updated Sep 13 2026, 5:42 PM

2026 College Football Odds Week 3: Lines, Spreads, Betting Trends on Biggest Games

Patrick Everson
Patrick Everson Sports Betting Expert
10 minute read
2026 College Football Odds Week 3: Lines, Spreads, Betting Trends on Biggest Games

The College Football Odds Week 3 market includes an SEC clash that's been on everyone's radar all year.

Lane Kiffin leads LSU against his former team Ole Miss, higlighting College Football Week 3 Odds. Also on the docket: Houston vs. Texas Tech and SMU vs. Louisville.

Here’s everything you need to know about 2026 college football odds Week 3: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 3 college football odds and action.

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Updated on 9/13/26

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2026 College Football Odds for Week 1

Miami vs. Wake Forest Odds

  • Opening point spread: Miami -22.5
  • Opening moneyline: Miami TBA/Wake Forest TBA
  • Opening total: Over/Under 55.5 points scored
  • Time: 7:30 p.m. ET Friday (ESPN)

OPENING ODDS UPDATE: Miami (2-0 SU and ATS) won its first two games by a combined 122-13. In Week 2 against FCS foe Florida A&M, the Hurricanes plowed to a 77-7 win and cover as massive 59.5-point home favorites.

Wake Forest (2-0 SU/0-2 ATS) blew a 23-13 fourth-quarter lead at Purdue, getting forced to overtime in a 23-23 tie. But the Demon Deacons escaped with a 38-36 double-OT road win while failing to cover as 2.5-point favorites.

Circa Sports often gets hit with respected action on its college football openers. But that wasn't the case in this matchup. On Sunday afternoon, Circa opened Miami -22.5, with no early movement.

Houston vs. Texas Tech Odds

  • Opening point spread: Texas Tech -10
  • Opening moneyline: Texas Tech TBA/Houston TBA
  • Opening total: Over/Under 53 points scored
  • Time: 8 p.m. ET Friday (FOX)

OPENING ODDS UPDATE: Texas Tech (2-0 SU/0-2 ATS) got far more than it expected in Week 2 at Oregon State. The Red Raiders closed as 25.5-point favorites and trailed 24-21 in the fourth quarter. But Tech put up the final two scores, both touchdowns, in a 35-24 victory.

Houston (2-0 SU/1-1 ATS) tuned up for its Big 12 opener with an overmatched FCS opponent in Southern University. The Cougars rumbled to a 77-6 victory laying a hefty 52 points at home.

This Big 12 battle is on the move early at Circa Sports. The Red Raiders opened -10 and quickly fell to -8.5 on Sunday afternoon, indicating early sharp play on underdog Houston.

SMU vs. Louisville Odds

  • Opening point spread: Louisville -2
  • Opening moneyline: Louisville TBA/SMU TBA
  • Opening total: Over/Under 61 points scored
  • Time: 3:30 p.m. ET Saturday (TV TBA)

OPENING ODDS UPDATE: Louisville (1-1 SU/2-0 ATS) took Ole Miss to the wire in Week 1, then came back with an easy Week 2 win. The Cardinals drilled FCS foe Villanova 59-13 giving 38.5 points at home.

SMU (2-0 SU and ATS) knocked off Florida State in Week 1, then mimicked Louisville with an FCS opponent in Week 2. The Mustangs belted UC Davis 56-10, easily cashing as 32.5-point home favorites.

On Sunday afternoon, Circa Sports opened Louisville as 2-point home chalk, with no early movement. But sharp play apparently hit the Under right away, as the total slid from 61 to 59.

LSU vs. Ole Miss Odds

  • Opening point spread: LSU -3
  • Opening moneyline: LSU TBA/Ole Miss TBA
  • Opening total: Over/Under 59 points scored
  • Time: 7:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: LSU (2-0 SU/1-1 ATS) hits the road for the first time this season, after blowout home wins over Clemson and Louisiana Tech. In Week 2, the Tigers topped LaTech 45-14, but fell short of covering the 34.5-point spread.

Ole Miss (2-0 SU and ATS) narrowly escaped Week 1 with a win over Louisville. Week 2 was a much easier task, with the Rebels coasting past Charlotte 41-9 as healthy 44.5-point home favorites.

Circa Sports opened the Tigers as 3-point road favorites, and that didn't attract any sharp action early, with LSU sticking at -3.

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Patrick Everson

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson
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