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Featured Last Updated Sep 13 2026, 11:30 PM

NFL Week 2 Odds: Lines, Spreads, Betting Trends for Every Game

Patrick Everson
Patrick Everson Sports Betting Expert
21 minute read
NFL Week 2 Odds: Lines, Spreads, Betting Trends for Every Game

2026 NFL Week 2 Odds

Matchup Spread Total Moneyline
Bills vs
Lions 		-3 (-115)
+3 (-105) 		o51.5 (-115)
u51.5 (-105) 		-166
+140
Jets vs
Packers 		+5.5 (-110)
-5.5 (-110) 		o42.5 (-110)
u42.5 (-110) 		+200
-245
Bears vs
Vikings 		-3 (-110)
+3 (-110) 		o45.5 (-110)
u45.5 (-110) 		-170
+142
Patriots vs
Steelers 		-4.5 (-105)
+4.5 (-115) 		o43.5 (-110)
u43.5 (-110) 		-205
+170
Falcons vs
Panthers 		-1.5 (-110)
+1.5 (-110) 		o42.5 (-110)
u42.5 (-110) 		-122
+102
Buccaneers vs
Browns 		-6.5 (-110)
+6.5 (-110) 		o42.5 (-110)
u42.5 (-110) 		-278
+225
Texans vs
Bengals 		-2.5 (-118)
+2.5 (-102) 		o45.5 (-110)
u45.5 (-110) 		-148
+124
Ravens vs
Saints 		-7.5 (-110)
+7.5 (-110) 		o46.5 (-110)
u46.5 (-110) 		-360
+285
Titans vs
Eagles 		+5.5 (-110)
-5.5 (-110) 		o42.5 (-110)
u42.5 (-110) 		+190
-230
Chargers vs
Raiders 		-9.5 (-110)
+9.5 (-110) 		o42.5 (-110)
u42.5 (-110) 		-380
+300
Broncos vs
Jaguars 		-3 (-110)
+3 (-110) 		o43.5 (-110)
u43.5 (-110) 		-155
+130
Cowboys vs
Commanders 		-4.5 (-105)
+4.5 (-115) 		o51.5 (-110)
u51.5 (-110) 		-198
+164
Cardinals vs
Seahawks 		+10 (-110)
-10 (-110) 		o44.5 (-110)
u44.5 (-110) 		+410
-550
49ers vs
Dolphins 		-10.5 (-110)
+10.5 (-110) 		o46.5 (-110)
u46.5 (-110) 		-675
+490
Chiefs vs
Colts 		-6.5 (-110)
+6.5 (-110) 		o47.5 (-110)
u47.5 (-110) 		-278
+225
Rams vs
Giants 		-9.5 (-112)
+9.5 (-108) 		o48.5 (-110)
u48.5 (-110) 		-485
+370

NFL Week 2 odds feature a few marquee matchups, opening with a Thursday night clash that has potential for plenty of scoring.

Detroit Lions vs. Buffalo Bills kicks off Week 2 NFL odds. Other notable contests: Pittsburgh Steelers vs. New England Patriots, Jacksonville Jaguars vs. Denver Broncos and Washington Commanders vs. Dallas Cowboys.

Here’s everything you need to know about NFL odds Week 2: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on odds and action.

Prediction markets are in the mix, as well, so check out our Kalshi referral code and get in on the action today. Also, check back regularly for updates and use our bet365 bonus code to get the most out of your action.

Updated on 9/14/26

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(Feature image: David Banks/Imagn Images)

2026 NFL Odds for Week 2

Detroit Lions vs. Buffalo Bills Odds

DET @ BUF Odds

  • Full Game
  • 1H
  • 1Q
  • Spread
  • Total
  • Moneyline
Detroit Lions 103 Lions
+3 -110 N/A N/A N/A N/A N/A +3.5 -125 + N/A +3.5 -115  
Buffalo Bills 104 Bills
-3 -110 N/A N/A N/A N/A N/A -3.5 +105 + N/A -3.5 -105  
Detroit Lions 103 Lions
o52.5 -110 N/A N/A N/A N/A N/A o26.5 -125 + N/A o53.5 -110  
Buffalo Bills 104 Bills
u52.5 -110 N/A N/A N/A N/A N/A u26.5 -105 + N/A u53.5 -110  
Detroit Lions 103 Lions
+136 N/A N/A N/A N/A N/A +150 + N/A +150  
Buffalo Bills 104 Bills
-162 N/A N/A N/A N/A N/A -180 + N/A -180  
Detroit Lions 103 Lions
+3 -110 N/A N/A N/A N/A N/A +0.5 -120 + N/A +3.5 -115  
Buffalo Bills 104 Bills
-3 -110 N/A N/A N/A N/A N/A -0.5 even + N/A -3.5 -105  
Detroit Lions 103 Lions
o52.5 -110 N/A N/A N/A N/A N/A o9.5 -165 + N/A o53.5 -110  
Buffalo Bills 104 Bills
u52.5 -110 N/A N/A N/A N/A N/A u9.5 +120 + N/A u53.5 -110  
Detroit Lions 103 Lions
+136 N/A N/A N/A N/A N/A +140 + N/A +150  
Buffalo Bills 104 Bills
-162 N/A N/A N/A N/A N/A -185 + N/A -180  
  • Opening point spread: Bills -3.5
  • Opening moneyline: Bills -185/Lions +150
  • Opening total: Over/Under 53.5 points scored
  • Time: 8:15 p.m. ET Thursday (Prime)

OPENING ODDS UPDATE: Buffalo (1-0 SU and ATS) notched a Week 1 road win that could prove important as the season wears on. The Bills went to Houston as 1.5-point favorites and won a shootout 36-31.

Buffalo took the lead on a Joshua Palmer 34-yard touchdown catch with 1:37 remaining. But it got sweaty from there, as the Texans drove inside the 10-yard line, but a Bills strip-sack of Houston QB C.J. Stroud clinched the win.

Detroit (1-0 SU/0-1 ATS) got an equally stiff Week 1 challenge from a much less expected source. The Lions led New Orleans 21-0 midway through the third quarter, but gave it all back, getting dragged to overtime in a 24-24 tie.

An Amon-Ra St. Brown 4-yard TD catch to open OT put Detroit up 31-24. New Orleans countered with a TD of its own, but went for 2 and the win and failed, giving the Lions a 31-30 victory as 7-point home favorites.

Borgata Sports, a BetMGM shop in Atlantic City, opened Lions-Bills at Buffalo -3.5, with no movement Sunday night in NFL Week 2 odds.

"The Bills put up 36 on the road against a team many were saying had the best defense in the league," Borgata sportsbook director Tom Gable said. "The Lions played OT against the Saints in a game that seemed would be a dead Under, but then ended up going Over with overtime.

"I’m expecting the public to come in here early on the Over, even with the extremely high total. But the very early money has been on the Bills and the Under."

Pittsburgh Steelers vs. New England Patriots Odds

PIT @ NE Odds

  • Full Game
  • 1H
  • 1Q
  • Spread
  • Total
  • Moneyline
Pittsburgh Steelers 255 Steelers
+4.5 -110 N/A N/A N/A N/A N/A +3.5 -115 + N/A +5.5 -110  
New England Patriots 256 Patriots
-4.5 -110 N/A N/A N/A N/A N/A -3.5 -105 + N/A -5.5 -110  
Pittsburgh Steelers 255 Steelers
o43.5 -110 N/A N/A N/A N/A N/A o20.5 -115 + N/A o43.5 -105  
New England Patriots 256 Patriots
u43.5 -110 N/A N/A N/A N/A N/A u20.5 -115 + N/A u43.5 -115  
Pittsburgh Steelers 255 Steelers
+185 N/A N/A N/A N/A N/A +170 + N/A +200  
New England Patriots 256 Patriots
-225 N/A N/A N/A N/A N/A -205 + N/A -245  
Pittsburgh Steelers 255 Steelers
+4.5 -110 N/A N/A N/A N/A N/A +0.5 -115 + N/A +5.5 -110  
New England Patriots 256 Patriots
-4.5 -110 N/A N/A N/A N/A N/A -0.5 -105 + N/A -5.5 -110  
Pittsburgh Steelers 255 Steelers
o43.5 -110 N/A N/A N/A N/A N/A o7.5 even + N/A o43.5 -105  
New England Patriots 256 Patriots
u43.5 -110 N/A N/A N/A N/A N/A u7.5 -135 + N/A u43.5 -115  
Pittsburgh Steelers 255 Steelers
+185 N/A N/A N/A N/A N/A +150 + N/A +200  
New England Patriots 256 Patriots
-225 N/A N/A N/A N/A N/A -200 + N/A -245  
  • Opening point spread: Patriots -5
  • Opening moneyline: Patriots -250/Steelers +195
  • Opening total: Over/Under 43.5 points scored
  • Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: New England (0-1 SU/1-0 ATS) had a golden opportunity to avenge its Super Bowl 60 loss to Seattle. The Seahawks lost QB Sam Darnold in the first quarter, and the Patriots built a 10-0 lead in a rare Wednesday night season kickoff.

But that was the scoring New England would get, and Drake Maye threw three fourth-quarter interceptions. The last was the killer, in the end zone in the waning seconds, as the Pats lost 13-10 catching 3.5 points on the road.

Pittsburgh (1-0 SU and ATS) benefited from facing third-string QB Cooper Rush in Week 1. The Steelers topped Atlanta 20-13 laying 6.5 points at home. T.J. Watt had a 35-yard interception return for a TD early in the fourth quarter, which ultimately proved to be the difference.

The Pats opened -5 in Borgata Sports' Week 2 NFL odds, with a total of 43.5

"The total has already ticked down a half-point," Borgata sportsbook director Tom Gable said. "The Steelers were a hugely popular choice for Week 1, with the injuries around the Atlanta QB room. They got the job done.

"But now they have to head on the road to New England, where the early money has been on the Patriots."

Cincinnati Bengals vs. Houston Texans Odds

CIN @ HOU Odds

  • Full Game
  • 1H
  • 1Q
  • Spread
  • Total
  • Moneyline
Cincinnati Bengals 261 Bengals
+2.5 -110 N/A N/A N/A N/A N/A +1.5 -105 + N/A +2.5 -105  
Houston Texans 262 Texans
-2.5 -110 N/A N/A N/A N/A N/A -1.5 -115 + N/A -2.5 -115  
Cincinnati Bengals 261 Bengals
o46.5 -110 N/A N/A N/A N/A N/A o24.5 +105 + N/A o47.5 -110  
Houston Texans 262 Texans
u46.5 -110 N/A N/A N/A N/A N/A u24.5 -140 + N/A u47.5 -110  
Cincinnati Bengals 261 Bengals
+114 N/A N/A N/A N/A N/A +125 + N/A +120  
Houston Texans 262 Texans
-135 N/A N/A N/A N/A N/A -150 + N/A -142  
Cincinnati Bengals 261 Bengals
+2.5 -110 N/A N/A N/A N/A N/A +0.5 -140 + N/A +2.5 -105  
Houston Texans 262 Texans
-2.5 -110 N/A N/A N/A N/A N/A -0.5 +115 + N/A -2.5 -115  
Cincinnati Bengals 261 Bengals
o46.5 -110 N/A N/A N/A N/A N/A o9.5 -115 + N/A o47.5 -110  
Houston Texans 262 Texans
u46.5 -110 N/A N/A N/A N/A N/A u9.5 -115 + N/A u47.5 -110  
Cincinnati Bengals 261 Bengals
+114 N/A N/A N/A N/A N/A +115 + N/A +120  
Houston Texans 262 Texans
-135 N/A N/A N/A N/A N/A -150 + N/A -142  
  • Opening point spread: Texans -2.5
  • Opening moneyline: Texans -145/Bengals +120
  • Opening total: Over/Under 47.5 points scored
  • Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Cincinnati (1-0 SU and ATS) rode an early scoop-and-score and more to a 21-3 lead, but ultimately had to fight off Tampa Bay. The Bengals held on for a 33-27 win as 3.5-point home favorites.

Houston (0-1 SU and ATS) drew a tough Week 1 home tilt vs. Buffalo and almost got there. The Texans led 31-30, but gave up a late TD in a 36-31 loss as 1.5-point home underdogs.

On Sunday night, Borgata Sports pegged the Texans 2.5-point home favorites in the NFL odds Week 2 market.

"Let’s see if the Texans' defense can bounce back, with a dangerous Cincy offense coming to town," Borgata sportsbook director Tom Gable said. "I could see this number maybe touch 3 briefly, but I don’t believe it stays there."

Minnesota Vikings vs. Chicago Bears Odds

  • Opening point spread: Bears -5
  • Opening moneyline: Bears -235/Vikings +200
  • Opening total: Over/Under 48 points scored
  • Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Chicago (1-0 SU and ATS) lived up to coach Ben Johnson's comments to pile up points this season. In Week 1, the Bears nearly hung a 60-burger on Carolina, rolling to a 59-37 victory as 3-point road faves.

The Bears led 31-24 at halftime, but kept pouring it on from there.

Minnesota (1-0 SU and ATS) dug itself out of a 22-10 hole over the final 20 minutes. In fact, the Vikings scored the final 29 points to top Green Bay 39-22 laying 2.5 points at home.

In NFL Week 2 odds, BetMGM opened the Bears -5, with no movement so far. But the total got a Sunday night nudge, from 48 to 48.5.

New Orleans Saints vs. Baltimore Ravens Odds

NO @ BAL Odds

  • Full Game
  • 1H
  • 1Q
  • Spread
  • Total
  • Moneyline
New Orleans Saints 263 Saints
+7.5 -110 N/A N/A N/A N/A N/A +5.5 even + N/A +8.5 -110  
Baltimore Ravens 264 Ravens
-7.5 -110 N/A N/A N/A N/A N/A -5.5 -120 + N/A -8.5 -110  
New Orleans Saints 263 Saints
o46.5 -110 N/A N/A N/A N/A N/A o24.5 +105 + N/A o48.5 -110  
Baltimore Ravens 264 Ravens
u46.5 -110 N/A N/A N/A N/A N/A u24.5 -140 + N/A u48.5 -110  
New Orleans Saints 263 Saints
+300 N/A N/A N/A N/A N/A +250 + N/A +310  
Baltimore Ravens 264 Ravens
-380 N/A N/A N/A N/A N/A -320 + N/A -395  
New Orleans Saints 263 Saints
+7.5 -110 N/A N/A N/A N/A N/A +3.5 -125 + N/A +8.5 -110  
Baltimore Ravens 264 Ravens
-7.5 -110 N/A N/A N/A N/A N/A -3.5 +105 + N/A -8.5 -110  
New Orleans Saints 263 Saints
o46.5 -110 N/A N/A N/A N/A N/A o9.5 -125 + N/A o48.5 -110  
Baltimore Ravens 264 Ravens
u46.5 -110 N/A N/A N/A N/A N/A u9.5 -105 + N/A u48.5 -110  
New Orleans Saints 263 Saints
+300 N/A N/A N/A N/A N/A +200 + N/A +310  
Baltimore Ravens 264 Ravens
-380 N/A N/A N/A N/A N/A -275 + N/A -395  
  • Opening point spread: Ravens -8.5
  • Opening moneyline: Ravens -450/Saints +340
  • Opening total: Over/Under 48.5 points scored
  • Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Baltimore (1-0 SU and ATS) ran out to 31-13 halftime lead at Baltimore in Week 1. The Ravens let off the gas from there, easing to a 41-23 victory giving 3 points.

New Orleans (0-1 SU/1-0 ATS) fell into a 21-0 hole, then somehow gave Detroit far more than anyone expected Sunday. The Saints rallied to tie at at 24 and force overtime, then came up just short 31-30 catching 7 points on the road.

New Orleans gave up a TD on the opening drive of OT, then countered with a Noah Fant 4-yard TD to pull within 31-30. But the Saints then went for the 2-point conversion and the win, and the attempt failed.

Even with the Saints' surprising showing, BetMGM opened the Ravens -8.5 Sunday night and advanced to -9 within a couple hours. The total was on the move in the first hour, from 48.5 to 48/47.5, before settling at 48.

Philadelphia Eagles vs. Tennessee Titans Odds

PHI @ TEN Odds

  • Full Game
  • 1H
  • 1Q
  • Spread
  • Total
  • Moneyline
Philadelphia Eagles 265 Eagles
-4.5 -110 N/A N/A N/A N/A N/A -2.5 -140 + N/A -7 -110  
Tennessee Titans 266 Titans
+4.5 -110 N/A N/A N/A N/A N/A +2.5 +115 + N/A +7 -110  
Philadelphia Eagles 265 Eagles
o42.5 -110 N/A N/A N/A N/A N/A o18.5 -140 + N/A o40.5 -105  
Tennessee Titans 266 Titans
u42.5 -110 N/A N/A N/A N/A N/A u18.5 +105 + N/A u40.5 -115  
Philadelphia Eagles 265 Eagles
-218 N/A N/A N/A N/A N/A -225 + N/A -305  
Tennessee Titans 266 Titans
+180 N/A N/A N/A N/A N/A +185 + N/A +245  
Philadelphia Eagles 265 Eagles
-4.5 -110 N/A N/A N/A N/A N/A -0.5 -105 + N/A -7 -110  
Tennessee Titans 266 Titans
+4.5 -110 N/A N/A N/A N/A N/A +0.5 -115 + N/A +7 -110  
Philadelphia Eagles 265 Eagles
o42.5 -110 N/A N/A N/A N/A N/A o7.5 +110 + N/A o40.5 -105  
Tennessee Titans 266 Titans
u42.5 -110 N/A N/A N/A N/A N/A u7.5 -150 + N/A u40.5 -115  
Philadelphia Eagles 265 Eagles
-218 N/A N/A N/A N/A N/A -205 + N/A -305  
Tennessee Titans 266 Titans
+180 N/A N/A N/A N/A N/A +155 + N/A +245  
  • Opening point spread: Eagles -7
  • Opening moneyline: Eagles -325/Titans +270
  • Opening total: Over/Under 40 points scored
  • Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Philadelphia (1-0 SU/0-1 ATS) let a 14-3 second-quarter lead slip away vs. Washington. The Eagles ultimately had to stop a 2-point conversion to escape with a 24-22 victory as 6-point home favorites.

Tennessee (0-1 SU and ATS) didn't muster a Week 1 touchdown until the final drive of the game. That was far too late, as the 1.5-point home favorite Titans fell to the Jets 23-10.

For Eagles-Titans, Philly opened and remains -7 late Sunday night in BtMGM's NFL odds Week 2.

Green Bay Packers vs. New York Jets Odds

GB @ NYJ Odds

  • Full Game
  • 1H
  • 1Q
  • Spread
  • Total
  • Moneyline
Green Bay Packers 251 Packers
-6.5 -110 N/A N/A N/A N/A N/A -2.5 -120 + N/A -4.5 -110  
New York Jets 252 Jets
+6.5 -110 N/A N/A N/A N/A N/A +2.5 even + N/A +4.5 -110  
Green Bay Packers 251 Packers
o42.5 -110 N/A N/A N/A N/A N/A o22.5 -115 + N/A o45.5 -110  
New York Jets 252 Jets
u42.5 -110 N/A N/A N/A N/A N/A u22.5 -115 + N/A u45.5 -110  
Green Bay Packers 251 Packers
-285 N/A N/A N/A N/A N/A -175 + N/A -225  
New York Jets 252 Jets
+230 N/A N/A N/A N/A N/A +145 + N/A +185  
Green Bay Packers 251 Packers
-6.5 -110 N/A N/A N/A N/A N/A -0.5 +110 + N/A -4.5 -110  
New York Jets 252 Jets
+6.5 -110 N/A N/A N/A N/A N/A +0.5 -135 + N/A +4.5 -110  
Green Bay Packers 251 Packers
o42.5 -110 N/A N/A N/A N/A N/A o7.5 -110 + N/A o45.5 -110  
New York Jets 252 Jets
u42.5 -110 N/A N/A N/A N/A N/A u7.5 -120 + N/A u45.5 -110  
Green Bay Packers 251 Packers
-285 N/A N/A N/A N/A N/A -165 + N/A -225  
New York Jets 252 Jets
+230 N/A N/A N/A N/A N/A +125 + N/A +185  
  • Opening point spread: Packers -4.5
  • Opening moneyline: Packers -235/Jets +190
  • Opening total: Over/Under 43.5 points scored
  • Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Green Bay (0-1 SU and ATS) held a 22-10 third-quarter lead at Minnesota and appeared on the way to a modest road upset. But the Packers gave up the game's final 29 points, getting smoked 39-22 as 2.5-point underdogs.

New York (1-0 SU and ATS) went to Tennessee as a 1.5-point underdog. But the Jets surprisingly built a 23-3 fourth-quarter lead in a 23-10 Week 1 victory.

BetMGM opened Packers vs. Jets at Green Bay -4.5 and saw only a few juice adjustments Sunday night, with the Pack now -4.5 (-105). The total was on the move, though, scooting from 43.5 to 44/44.5 before stopping at 45.

Carolina Panthers vs. Atlanta Falcons Odds

CAR @ ATL Odds

  • Full Game
  • 1H
  • 1Q
  • Spread
  • Total
  • Moneyline
Carolina Panthers 257 Panthers
+1.5 -115 N/A N/A N/A N/A N/A -0.5 +115 + N/A +1.5 -110  
Atlanta Falcons 258 Falcons
-1.5 -105 N/A N/A N/A N/A N/A +0.5 -140 + N/A -1.5 -110  
Carolina Panthers 257 Panthers
o43.5 -110 N/A N/A N/A N/A N/A o22.5 -110 + N/A o44.5 -110  
Atlanta Falcons 258 Falcons
u43.5 -110 N/A N/A N/A N/A N/A u22.5 -120 + N/A u44.5 -110  
Carolina Panthers 257 Panthers
even N/A N/A N/A N/A N/A -105 + N/A -102  
Atlanta Falcons 258 Falcons
-120 N/A N/A N/A N/A N/A -115 + N/A -118  
Carolina Panthers 257 Panthers
+1.5 -115 N/A N/A N/A N/A N/A +0.5 -175 + N/A +1.5 -110  
Atlanta Falcons 258 Falcons
-1.5 -105 N/A N/A N/A N/A N/A -0.5 +140 + N/A -1.5 -110  
Carolina Panthers 257 Panthers
o43.5 -110 N/A N/A N/A N/A N/A o7.5 -105 + N/A o44.5 -110  
Atlanta Falcons 258 Falcons
u43.5 -110 N/A N/A N/A N/A N/A u7.5 -125 + N/A u44.5 -110  
Carolina Panthers 257 Panthers
even N/A N/A N/A N/A N/A -110 + N/A -102  
Atlanta Falcons 258 Falcons
-120 N/A N/A N/A N/A N/A -120 + N/A -118  
  • Opening point spread: Falcons -1.5
  • Opening moneyline: Falcons -120/Panthers even
  • Opening total: Over/Under 44 points scored
  • Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Carolina (0-1 SU and ATS) kept up with Chicago in a first-half shootout, trailing 31-24 at halftime. But the Panthers couldn't handle that pace in the second half, getting blown out 59-37 as 3-point home 'dogs.

Atlanta (0-1 SU and ATS) trotted out third-string QB Cooper Rush in Week 1, with Tua Tagovailoa and Michael Penix both injured. And the Falcons actually acquitted themselves well, but lost to Pittsburgh 20-13 as 6.5-point road pups.

Atlanta opened -1.5 in BetMGM's NFL Week 1 odds, with no movement Sunday night.

Cleveland Browns vs. Tampa Bay Buccaneers Odds

CLE @ TB Odds

  • Full Game
  • 1H
  • 1Q
  • Spread
  • Total
  • Moneyline
Cleveland Browns 259 Browns
+5.5 -110 N/A N/A N/A N/A N/A +5.5 -105 + N/A +8.5 -110  
Tampa Bay Buccaneers 260 Buccaneers
-5.5 -110 N/A N/A N/A N/A N/A -5.5 -115 + N/A -8.5 -110  
Cleveland Browns 259 Browns
o42.5 -110 N/A N/A N/A N/A N/A o20.5 -115 + N/A o40.5 -110  
Tampa Bay Buccaneers 260 Buccaneers
u42.5 -110 N/A N/A N/A N/A N/A u20.5 -115 + N/A u40.5 -110  
Cleveland Browns 259 Browns
+200 N/A N/A N/A N/A N/A +240 + N/A +295  
Tampa Bay Buccaneers 260 Buccaneers
-245 N/A N/A N/A N/A N/A -300 + N/A -375  
Cleveland Browns 259 Browns
+5.5 -110 N/A N/A N/A N/A N/A +2.5 +105 + N/A +8.5 -110  
Tampa Bay Buccaneers 260 Buccaneers
-5.5 -110 N/A N/A N/A N/A N/A -2.5 -125 + N/A -8.5 -110  
Cleveland Browns 259 Browns
o42.5 -110 N/A N/A N/A N/A N/A o7.5 even + N/A o40.5 -110  
Tampa Bay Buccaneers 260 Buccaneers
u42.5 -110 N/A N/A N/A N/A N/A u7.5 -135 + N/A u40.5 -110  
Cleveland Browns 259 Browns
+200 N/A N/A N/A N/A N/A +200 + N/A +295  
Tampa Bay Buccaneers 260 Buccaneers
-245 N/A N/A N/A N/A N/A -275 + N/A -375  
  • Opening point spread: Buccaneers -8.5
  • Opening moneyline: Buccaneers -425/Browns +333
  • Opening total: Over/Under 40.5 points scored
  • Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Tampa Bay (0-1 SU and ATS) found itself in a 21-3 hole with 5.5 minutes remaining in the first half. Baker Mayfield and the Bucs then rallied to make it interesting, but lost to Cincinnati 33-27 getting 3.5 points on the road.

Cleveland (0-1 SU and ATS) got Deshaun Watson back on the field, but it didn't matter much in Week 1. The Browns gave up the first 31 points at Jacksonville in a 34-10 loss as 8.5-point underdogs.

The Bucs opened -8.5 at BetMGM, with no Sunday night moves.

Jacksonville Jaguars vs. Denver Broncos Odds

  • Opening point spread: Broncos -2.5
  • Opening moneyline: Broncos -145/Jaguars +120
  • Opening total: Over/Under 44 points scored
  • Time: 4:05 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Jacksonville (1-0 SU and ATS) had four Trevor Lawrence TD passes and a 31-0 lead just three minutes into the third quarter vs. Cleveland. From there, the Jaguars coasted to a 34-10 victory laying 8.5 points at home.

Denver (0-0 SU and ATS) still has Week 1 work to do, with a huge Monday night date in Kansas City. Borgata Sports went ahead and opened the Broncos -2.5 vs. the Jaguars.

"The Jags looked like a professional football team vs. a JV team for much of their Week 1 game. It's a different story here, but we will see how Denver comes out of Monday night," Borgata sportsbook director Tom Gable said.

Las Vegas Raiders vs. Los Angeles Chargers Odds

LV @ LAC Odds

  • Full Game
  • 1H
  • 1Q
  • Spread
  • Total
  • Moneyline
Las Vegas Raiders 267 Raiders
+8.5 -110 N/A N/A N/A N/A N/A +3.5 +105 + N/A +7 -115  
Los Angeles Chargers 268 Chargers
-8.5 -110 N/A N/A N/A N/A N/A -3.5 -125 + N/A -7 -105  
Las Vegas Raiders 267 Raiders
o42.5 -110 N/A N/A N/A N/A N/A o22.5 -110 + N/A o44.5 -110  
Los Angeles Chargers 268 Chargers
u42.5 -110 N/A N/A N/A N/A N/A u22.5 -120 + N/A u44.5 -110  
Las Vegas Raiders 267 Raiders
+330 N/A N/A N/A N/A N/A +200 + N/A +235  
Los Angeles Chargers 268 Chargers
-425 N/A N/A N/A N/A N/A -245 + N/A -290  
Las Vegas Raiders 267 Raiders
+8.5 -110 N/A N/A N/A N/A N/A +2.5 even + N/A +7 -115  
Los Angeles Chargers 268 Chargers
-8.5 -110 N/A N/A N/A N/A N/A -2.5 -120 + N/A -7 -105  
Las Vegas Raiders 267 Raiders
o42.5 -110 N/A N/A N/A N/A N/A o7.5 -110 + N/A o44.5 -110  
Los Angeles Chargers 268 Chargers
u42.5 -110 N/A N/A N/A N/A N/A u7.5 -120 + N/A u44.5 -110  
Las Vegas Raiders 267 Raiders
+330 N/A N/A N/A N/A N/A +175 + N/A +235  
Los Angeles Chargers 268 Chargers
-425 N/A N/A N/A N/A N/A -235 + N/A -290  
  • Opening point spread: Chargers -7.5
  • Opening moneyline: Chargers -350/Raiders +290
  • Opening total: Over/Under 45 points scored
  • Time: 4:05 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Los Angeles (0-1 SU and ATS) suffered the biggest upset of Week 1, against a team with a season win total of 3.5. The Chargers closed as 9.5-point home favorites, but never led in a stunning 26-14 loss.

Las Vegas (1-0 SU and ATS) will eventually be Fernando Mendoza's team. But for now, it's Kirk Cousins, and that was plenty in Week 1 vs. Miami. Cousins had two TD passes, and the Raiders won 27-13 as 3-point home faves.

The Raiders-Chargers line bounced around a bit Sunday night in BetMGM's Week 2 NFL odds. L.A. opened -7.5 (-115), then dipped to 7/-6.5, before settling at -7 after a couple hours.

The total was in motion early, too, opening at 45, dropping to 44, then sticking at 44.5 (Under -115).

Washington Commanders vs. Dallas Cowboys Odds

  • Opening point spread: Cowboys -4.5
  • Opening moneyline: Cowboys -225/Commanders +190
  • Opening total: Over/Under 50 points scored
  • Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Dallas (0-1 SU and ATS) got its 2026 campaign off to an unceremonious start. The Cowboys closed as 3-point road favorites vs. the Giants and lost 28-20.

Washington (0-1 SU and ATS) rallied from a 14-3 second-quarter deficit at Philadelphia. But the Commanders ultimately fell just short, losing 24-22 as 6-point 'dogs. Jayden Daniels hit Antonio Williams on a 1-yard TD pass with 1:01 remaining, but the subsequent 2-point attempt failed.

Borgata Sports opened Commanders-Cowboys at Dallas -4.5, but that was before the Sunday night game.

"The Commanders are on my personal nice list, after they came through with the late cover against the Eagles, which carried the day for us," Borgata sportsbook director Tom Gable said. "We will probably need them again here against Dallas in Week 2."

Seattle Seahawks vs. Arizona Cardinals Odds

SEA @ ARI Odds

  • Full Game
  • 1H
  • 1Q
  • Spread
  • Total
  • Moneyline
Seattle Seahawks 273 Seahawks
-10 -110 N/A N/A N/A N/A N/A -2.5 -120 + N/A -4.5 -105  
Arizona Cardinals 274 Cardinals
+10 -110 N/A N/A N/A N/A N/A +2.5 even + N/A +4.5 -115  
Seattle Seahawks 273 Seahawks
o44.5 -110 N/A N/A N/A N/A N/A o20.5 +110 + N/A o41.5 -110  
Arizona Cardinals 274 Cardinals
u44.5 -110 N/A N/A N/A N/A N/A u20.5 -150 + N/A u41.5 -110  
Seattle Seahawks 273 Seahawks
-500 N/A N/A N/A N/A N/A -180 + N/A -225  
Arizona Cardinals 274 Cardinals
+380 N/A N/A N/A N/A N/A +150 + N/A +185  
Seattle Seahawks 273 Seahawks
-10 -110 N/A N/A N/A N/A N/A -0.5 +110 + N/A -4.5 -105  
Arizona Cardinals 274 Cardinals
+10 -110 N/A N/A N/A N/A N/A +0.5 -135 + N/A +4.5 -115  
Seattle Seahawks 273 Seahawks
o44.5 -110 N/A N/A N/A N/A N/A o7.5 even + N/A o41.5 -110  
Arizona Cardinals 274 Cardinals
u44.5 -110 N/A N/A N/A N/A N/A u7.5 -135 + N/A u41.5 -110  
Seattle Seahawks 273 Seahawks
-500 N/A N/A N/A N/A N/A -160 + N/A -225  
Arizona Cardinals 274 Cardinals
+380 N/A N/A N/A N/A N/A +120 + N/A +185  
  • Opening point spread: Seahawks -6
  • Opening moneyline: Seahawks -275/Cardinals +225
  • Opening total: Over/Under TBA points scored
  • Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Seattle (1-0 SU/0-1 ATS) lost QB Sam Darnold to a hip injury on its first possession of the season. Subsequently, the Seahawks fell into a 10-0 hole at home vs. New England on Wednesday.

But Seattle scored the game's final 13 points and got three fourth-quarter interceptions to win 13-10 laying 3.5 points. Seahawks cornerback Josh Jobe sealed the deal with an INT in the end zone in the waning seconds.

Arizona (1-0 SU and ATS) pulled off a Week 1 shocker. The Cards closed as 9.5-point road pups vs. the Chargers and never trailed in a 26-14 victory.

Early movement in NFL Week 2 odds shows the Cardinals perhaps commanding a little respect. BetMGM opened the Seahawks -6, even with Darnold expected to sit out. But the line fell to Seattle -5.5/-5 in short order and finished Sunday night at -4.5.

BetMGM's total was heading south, as well, falling from 43.5 to 41.

Miami Dolphins vs. San Francisco 49ers Odds

MIA @ SF Odds

  • Full Game
  • 1H
  • 1Q
  • Spread
  • Total
  • Moneyline
Miami Dolphins 275 Dolphins
+10.5 -110 N/A N/A N/A N/A N/A +7.5 -120 + N/A +12.5 -110  
San Francisco 49ers 276 49ers
-10.5 -110 N/A N/A N/A N/A N/A -7.5 even + N/A -12.5 -110  
Miami Dolphins 275 Dolphins
o46.5 -110 N/A N/A N/A N/A N/A o22.5 -120 + N/A o46.5 -110  
San Francisco 49ers 276 49ers
u46.5 -110 N/A N/A N/A N/A N/A u22.5 -110 + N/A u46.5 -110  
Miami Dolphins 275 Dolphins
+425 N/A N/A N/A N/A N/A +310 + N/A +600  
San Francisco 49ers 276 49ers
-575 N/A N/A N/A N/A N/A -400 + N/A -900  
Miami Dolphins 275 Dolphins
+10.5 -110 N/A N/A N/A N/A N/A +3.5 -110 + N/A +12.5 -110  
San Francisco 49ers 276 49ers
-10.5 -110 N/A N/A N/A N/A N/A -3.5 -110 + N/A -12.5 -110  
Miami Dolphins 275 Dolphins
o46.5 -110 N/A N/A N/A N/A N/A o7.5 -115 + N/A o46.5 -110  
San Francisco 49ers 276 49ers
u46.5 -110 N/A N/A N/A N/A N/A u7.5 -115 + N/A u46.5 -110  
Miami Dolphins 275 Dolphins
+425 N/A N/A N/A N/A N/A +250 + N/A +600  
San Francisco 49ers 276 49ers
-575 N/A N/A N/A N/A N/A -350 + N/A -900  
  • Opening point spread: 49ers -12.5
  • Opening moneyline: 49ers -900/Dolphins +650
  • Opening total: Over/Under 46 points scored
  • Time: 4:25 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: San Francisco (1-0 SU and ATS) rumbled to a surprising neutral-site win on Thursday in Melbourne, Australia. The Niners were 3.5-point underdogs and won 27-7 vs. the Super Bowl favorite Rams.

Miami (0-1 SU and ATS) started what expected to be a long year with a 27-13 loss vs. Las Vegas. The Dolphins, 3-point road underdogs, managed just two field goals and one touchdown, and didn't score in the game's final 27 minutes-plus.

San Fran is the biggest favorite on BetMGM's NFL Week 2 odds board, opening at -12.5 and visiting -13 for an hour Sunday night. The Niners then returned to -12.5. The total inched from 46 to 45.5.

Indianapolis Colts vs. Kansas City Chiefs Odds

  • Opening point spread: Chiefs -6.5
  • Opening moneyline: Chiefs -300/Colts +240
  • Opening total: Over/Under 48 points scored
  • Time: 8:20 p.m. ET Sunday (NBC)

OPENING ODDS UPDATE: Kansas City (0-0 SU and ATS) isn't yet out of Week 1. The Chiefs host the Broncos in an AFC West clash on Monday night.

Indianapolis (0-1 SU and ATS) gave up 31 first-half points to Baltimore and couldn't recover. The Colts fell 41-23 getting 3 points at home.

With the Chiefs playing in prime time at home for a second straight week, Borgata Sports opened K.C. as 6.5-point home chalk vs. Indy in NFL Week 2 odds.

"Indy had a rough time containing Baltimore at home," Borgata sportsbook director Tom Gable said. "Now the Colts have to travel to Arrowhead. Not much has come in early on this game, with the Chiefs still to play their Week 1 game."

New York Giants vs. Los Angeles Rams Odds

  • Opening point spread: Rams -8.5
  • Opening moneyline: Rams -450/Giants +350
  • Opening total: Over/Under 49 points scored
  • Time: 8:15 p.m. ET Monday (ESPN)

OPENING ODDS UPDATE: Los Angeles (0-1 SU and ATS) gets a much-needed mini-bye after stunningly getting smoked by San Francisco on Thursday. The Rams, the consensus favorite in Super Bowl odds, tumbled 27-7 as 3.5-point favorites Thursday in Melbourne, Australia.

L.A.'s only score was a Kyren Williams 5-yard TD run on the first play of the second quarter, to take a 7-3 lead.

Meanwhile, New York (1-0 SU and ATS) got its season off to a rousing start with a big win over an archrival. The Giants knocked off Dallas 28-20 as 3-point home 'dogs.

Still, the Rams opened as hefty 8.5-point home favorites in Borgata Sports' Week 2 NFL odds.

"There's some early local money on the Giants, but nothing of substance," Borgata sportsbook director Tom Gable said.

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Patrick Everson

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson
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