College Football Odds & Betting Lines
Be sure to check out our latest College Football National Championship odds.
Week 5
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Odds current as of September 27, 2025
College Football Odds
The 2025 College Football season is now in full force, and there are some huge Top 25 matchups in Week 5. Among the big games: No. 6 Oregon vs. No. 3 Penn State, No. 17 Alabama vs. No. 5 Georgia and No. 4 LSU vs. No. 13 Ole Miss.
Check out all you need to know in Patrick Everson's College Football Week 5 odds report!
Popular College Football Futures Markets
College Football Conference Winner Markets
- 2025 SEC Football Championship Odds
- 2025 Big Ten Football Championship Odds
- 2025 ACC Football Championship Odds
- 2025 Big 12 Football Championship Odds
- 2025 AAC Football Championship Odds
- 2025 Mountain West Conference Football Championship Odds
- 2025 Sun Belt Football Championship Odds
- 2025 C-USA Football Championship Odds
- 2025 MAC Football Championship Odds
Betting Odds Resources
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College Football Las Vegas Odds: NCAAF Spreads, Totals, & Moneylines
Every matchup is listed in order of Rotation, and those numbers are preceded by the Date and Time of the College Football game.
The rotation for college football games typically lists them by scheduled starting time, which can lead to confusion since the number will remain the same even if the games change due to television networks often shifting around action to present more attractive matchups. Home teams are listed at the bottom and will, therefore, be your even-numbered squad.
NCAAF Spreads
The numbers next to the teams are called Spreads or Point-Spreads.
Favorites are the teams laying points, which is represented by a minus (-) sign. The team in the Underdog role is getting points, which is represented by the plus (+) symbol that you wouldn’t see on the board but would be represented next team onto you betting ticket or slip. You can add the spread to your team’s final score and have that edge throughout the game.
If there is no favorite or underdog, the line is called pick’em and is represented by (PK). Winner takes it. The amount of points a team is favored by is set by oddsmakers on Sunday afternoons and that figure fluctuates throughout the week based on the amount of money coming in on bets.
NCAAF Over Unders
You’ll also find the Total next to Spread, representing what oddsmakers believe will be the combined number of points scored between the teams. That number also increases or decreases based on bets coming in on the Over or Under.
NCAAF Moneylines
Next to Spread, you will find Moneyline, a wager on which team will win the game outright, with no point spread needed.
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How to Bet College Football Las Vegas Odds
The key to wagering successfully in college football spread betting is to decide early how many points you’re willing to lay with Favorites and to get in at the lowest possible spot.
If you’re going to back the Underdog, make sure you’re getting the most points possible entering the game. The skill in this often requires you to forecast how a game will be wagered since we often see opening lines bet up over the course of the week due to the majority of the money coming in on the favorite.
Of course, getting in too early can often backfire if a better number appears over the course of the week or if injuries that are typically not announced until coaches give status reports on Monday press conferences dramatically alter expectations. There’s also a big rush on betting action just before the kickoff of any game, which means you may be best off waiting until kickoff approaches to get the right number.
Let's look at an example. Team A opened as an 11.5-point favorite and won 42-31 after Team B scored the game’s final touchdown with :48 left. Team B backers who got in early prevailed on that score, while Team A bettors who guessed wrong and got in too early caught a “bad beat.” Those who waited and laid only 10.5 points still cashed. Get in at the best number!
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VegasInsider Open & Consensus
College Football Opening Line
Opening Lines in college football are typically set on Sunday afternoons in the current week, and you usually see immediate action cause line movement. The Spread is based on a rough projection of a score for every matchup, although oddsmakers have a good idea of what side the betting public will want to bet on and usually saddles that team with an additional point or three. The same goes for the Total, which projects the combined number of points expected in a contest.
These numbers are based on simulations that take a number of statistical factors into account, in addition to baking in injuries, a home field advantage that is typically worth three points, and any other potential edges. Teams coming off bye weeks are usually given an edge thanks to increased preparation time and fresher bodies. Teams coming in on short rest or that have to travel out of their element typically find themselves penalized in a point spread.
VI Consensus College Football Line
When looking at the numbers over the course of the week, you’ll see constant line movement on our odds and matchup pages. All of the betting properties we track create their own lines and we display and track all of their movements in the VegasInsider Consensus Line. You'll see different numbers representing the current lines at any given point in the week, from when the line opens until just before kickoff. Those may vary from one another since properties offer up their own lines, so VI’s Consensus Line represents the one that appears most commonly.
The Total is also available on the VI Consensus line and similarly consists of the current betting line that is most frequently offered by our list of Las Vegas and Global sportsbooks.
Other Popular Betting Odds
Along with providing College Football Las Vegas Odds, VegasInsider is also the leader in betting numbers for the most popular sports that are wagered on in the United States.
Those sports and the betting odds can be found below:
- NFL Odds & Betting Lines
- MLB Odds & betting Lines
- NBA Odds & Betting Lines
- NHL Odds & Betting Lines
- College Basketball Odds & Betting Lines
- Soccer Odds & Betting Lines
- WNBA Las Vegas Odds
- CFL Odds & Betting Lines
- Tennis Futures Betting Odds
Betting on college football is always exciting, especially when you find the most optimal odds at the best sportsbooks. For Missouri college football fans, visit the best Missouri Sportsbooks.
