NFL Odds & Betting Lines
The 2025-26 NFL season is through nine weeks, with the NFL odds Week 10 market now in full swing.
Among the top matchups in NFL Week 10 odds: Philadelphia Eagles vs. Green Bay Packers, with both teams considered Super Bowl contenders. Los Angeles Rams vs. San Francisco 49ers is appealing, too, as is New England Patriots vs. Tampa Bay Buccaneers.
Below are odds for NFL Week 10, followed by insights on notable line moves. Also check out our complete NFL Odds Week 10 report. Looking for more NFL odds? Check out our extensive list of NFL player prop odds and NFL futures.
Check back later for Dylan Wilkerson's NFL Week 10 best bets.
(Feature image: Tork Mason/Imagn Images)
Week 10
NFL Odds Week 10
Notable Line Moves
LATEST UPDATE: As of 12:30 p.m. ET Tuesday, the big mover of the week is entirely due to big injury news. Washington Commanders QB Jayden Daniels suffered a dislocated left elbow in a 38-14 blowout Sunday night loss to Seattle.
In NFL Week 10 odds, DraftKings Sportsbook opened Lions-Commanders at Detroit -3, prior to Daniels' injury. Postgame, DK went straight to Detroit -7.5, then Monday advanced to -8.5.
Las Vegas Raiders vs. Denver Broncos kicks off Week 10, and that line is heading toward the road underdog early. The Broncos opened as 10-point chalk at DraftKings, toggled between -9.5/-8.5 Monday and are at -8.5 (-115) Tuesday afternoon.
With Lamar Jackson looking just fine in a 28-6 Week 9 win at Miami, Baltimore is out to a bigger road favorite vs. Minnesota. The Ravens opened -3 at DK, got to -3.5 late Sunday night and advanced to -4.5 Tuesday morning.
NFL Week 10 Opening Odds
DraftKings Sportsbook's opening odds for the 14 games of NFL Week 10 are listed below. 👇
Thursday, Nov. 6, 2025
- Raiders vs. Broncos (-10)
Sunday, Nov. 9, 2025
- Falcons vs. Colts (-6.5)
- Browns vs. Jets (-1.5)
- Saints vs. Panthers (-5.5)
- Bills (-9.5) vs. Dolphins
- Jaguars vs. Texans (-1.5)
- Ravens (-3) vs. Vikings
- Patriots vs. Buccaneers (-2.5)
- Giants vs. Bears (-3.5)
- Cardinals vs. Seahawks (-7)
- Lions (-3) vs. Commanders
- Rams (-3) vs. 49ers
- Steelers vs. Chargers (-3.5)
Monday, Nov. 10, 2025
- Eagles vs. Packers (-2.5)
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Odds current as of November 05, 2025
NFL Super Bowl Odds
2025-26 Super Bowl odds are in constant motion. Here are a handful of the top teams at BetMGM to hoist the Lombardi Trophy in February.
- Kansas City Chiefs +550
- Buffalo Bills +600
- Detroit Lions +850
- Philadelphia Eagles +850
- Los Angeles Rams +850
- Green Bay Packers +1000
- Indianapolis Colts +1300
- Seattle Seahawks +1400
- Baltimore Ravens +1600
- Denver Broncos +1600
- Tampa Bay Buccaneers +2000
- All other teams are +2800 or greater. For more, check out VegasInsider's complete Super Bowl Odds Report.
NFL Betting Odds Resources
There are a bunch of ways you can bet on the NFL. Not only do you have the usual moneyline betting and point spread betting, but you also have totals (over/under) betting, prop betting, first-half bets, second-half bets and more.
No matter what you're looking for, we have it for you at VegasInsider. If you're looking for the best odds and want to place a bet, you should check out our selection of the best sportsbooks in the US. In particular, our bet365 bonus code can provide a variety of useful betting options.
Take a look at the odds for every game this week above and also check out our slew of NFL Odds pages below:
Monday Night Football Odds | Thursday Night Football Odds | Super Bowl Promotions | Best NFL Betting Sites | NFL Player Prop Bets | Best NFL Parlays and Picks
Updated on: 2025-11-05
Updated on 11/5/25
🏆 Popular Super Bowl Markets & Other NFL Futures
- Super Bowl 60
- Win Totals
- Playoff (Yes-No)
- Most Valuable Player
- Rookie of the Year
- Player of the Year
- Comeback Player
- Coach of the Year
🏉 NFL Conference Winner Markets
🥇 NFL Division Winner Markets
- NFC East Division Winner Odds
- NFC West Division Winner Odds
- NFC South Division Winner Odds
- NFC North Division Winner Odds
- AFC East Division Winner Odds
- AFC West Division Winner Odds
- AFC South Division Winner Odds
- AFC North Division Winner Odds
How To Bet On The NFL
Betting on the NFL can seem simple, but there are some nuances to be aware of. Make sure to check out our football betting guide and how to bet on the Super Bowl pages for more in-depth information outside of the bet types listed below:
Point Spread Betting
Spread betting gets a bit more advanced than just "who's going to win", and requires you to have a solid knowledge of how a team might perform. For example, let's say Green Bay is listed as +3.5 (-110). That means that, in order for your bet to pay out on those -110 odds, the Packers need to either win the game or not lose by 4 points or more.
Moneyline Betting
Whether you're betting the Super Bowl futures or betting on a team to win tonight's game, you're probably looking at a moneyline. This is typically a straightforward "who's going to win" bet:
EXAMPLE: PHILADELPHIA (+600) TO WIN THE 2025-26 SUPER BOWL
Let's say the Eagles are listed as a 6/1 betting choice to win the Super Bowl. If you wager $100 on Philly to win Super Bowl 60 and they capture the championship, then you would win $600 (6/1 x 100). Your online betting account would then credit your account $700, which includes your win and stake ($100). However, if you're benefitting from a bonus betting credit, that doesn't count towards your stake, and you'll only receive your win.
The DraftKings Sportsbook promo code is a good choice for a welcome offer to secure before you start betting moneylines!
Totals Betting (Over/Under)
If you're betting totals, and you're probably seeing a pattern here, you're betting on the total number of points scored. These bet types are pretty logically named, no? Anyway, if you're betting on a Packers v. Bears matchup and the total is set at over or under 48.5, that means that oddsmakers don't expect the cumulative score earned by both teams to exceed 48. If it does, and you bet the OVER, you get a payout. If it doesn't and you bet the UNDER, you get a payout.
Parlay Betting
Parlay betting is not for the feint of heart, as we've said: it requires you to string together anywhere from 3-12 (and sometimes more) bets for a bigger payout. The only trick? Every single leg has to hit, otherwise you lose it all.
We're also seeing one-game or single game parlays on the board lately, and that's in large part due to the advent of live betting.
Prop Betting and Live Betting
Prop betting is a form of casual bet that doesn't really have to do with the outcome of a game. For example, you can have the more technical prop bets like "player to exceed X passing yards before the half" or "team to intercept before the quarter is finished". You can also have less technical bets like "color of Gatorade dumped on the coach", "will the mascot trip down the stairs today", or any number of novelty bets.
Throw in the fact that legal, online betting can be done from a mobile device, and live betting becomes possible: that's where you can place prop bets, including parlaying them together in single-game parlays, as the game is happening. Exciting times we live in!
Best NFL Betting Sites
We've reviewed some of the top NFL sportsbooks in the country and their exclusive promotions available for new and existing users. Check out our sportsbook reviews, learn about the Fanatics Sportsbook promo code, and read sections on providers to get all the information you need to get online and bet legally, including promos and bonuses to get you off on the right foot! Don't forget that Missouri sportsbooks are slated to launch on Dec. 1!
Otherwise, you can take advantage of our exclusive BetMGM Bonus Code
What Teams Can I Bet On?
VegasInsider Open and Consensus
NFL Opening Line
One of the best features on the NFL Vegas Odds is the Open Line. This numbers consists of the first betting line received from one of our preferred sportsbooks. The opening line varies depending on the sportsbook, but the figure provides a clear-cut rating as determined by the oddsmakers. If you’re betting on the NFL or any other sport, it’s a great idea to view the open line first.
VI Consensus NFL Line
The VegasInsider.com Consensus NFL Line is just as important as the Open Line and also a key resource on odds platform. The Consensus column could be called a “Median Line”, since it shows the most consistent number provided by the sportsbooks on VegasInsider.com. The consensus line will be the same as the open line but once the wagers start coming in, this number is often different than the openers.
NFL Odds FAQ
Why Would You Bet On Negative NFL Odds?
Negative NFL odds indicate that the bet is the favorite, which would lead to a lower payout. Positive NFL odds indicate an underdog bet, leading to a higher payout. Sometimes, taking a bet on the favorite makes sense if you don't see a clear path for the underdog to upset the expected result.
How Are NFL Odds Determined?
NFL odds are determined by professional oddsmakers employed by the top sportsbooks. Online betting odds usually reflect what is determined by oddsmakers at the nation's top casinos, many of which are in Las Vegas.
How Do I Read NFL Odds?
Reading the NFL odds is simple. Whether you're looking at totals bets, props, moneylines, or spread betting, the negative number indicates the favorite (and a lower payout) and the positive number indicates the underdog (and a higher payout). When betting the spread, there are also smaller numbers indicating the point difference, and for totals, the total number of expected points.
Who Are The Favorites To Win The NFL?
The Philadelphia Eagles won Super Bowl 59 and have opened as a +600 choice to repeat in Super Bowl 60. They are currently the favorites to win Super Bowl 60.
Super Bowl 60 Opening Odds Top 5 Contenders
- Philadelphia Eagles +600
- Kansas City Chiefs +700
- Buffalo Bills +700
- Baltimore Ravens +700
- Detroit Lions +1000
- More NFL Futures Odds
How Can I Win Betting On The NFL?
NFL betting is very involved and the lines are some of the most accurate in the market. As always, there's no guarantee for a winning strategy, but looking for value in less popular player props, underdogs with an improving record, and of course using the expert resources here at VegasInsider are a good start.
What Is A Point Spread In NFL Betting?
A point spread in NFL betting looks at the performance of a team regardless if they win or lose. A losing team can still win a point spread bet by "covering" the spread, and earning at least as many points as is set by the spread.
